Search Results - "Shankar, Manu"

Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak by Azoulay, Elie, De Waele, Jan, Ferrer, Ricard, Staudinger, Thomas, Borkowska, Marta, Povoa, Pedro, Iliopoulou, Katerina, Artigas, Antonio, Schaller, Stefan J., Hari, Manu Shankar, Pellegrini, Mariangela, Darmon, Michael, Kesecioglu, Jozef, Cecconi, Maurizio

“…Background The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers…”
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Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling by Arkless, Kate L., Pan, Dingxin, Shankar‐Hari, Manu, Amison, Richard T., Page, Clive P., Rahman, Khondaker Miraz, Pitchford, Simon C.

“…Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides. Non‐canonical signalling via the P2Y1…”
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Publisher Correction: The effect of blood pressure on mortality following out‑of‑hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database by McGuigan, Peter J, Giallongo, Elisa, Blackwood, Bronagh, Doidge, James, Harrison, David A, Nichol, Alistair D, Rowan, Kathryn M, Shankar-Hari, Manu, Skrifvars, Markus B, Thomas, Karen, McAuley, Danny F

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Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study by Hippisley-Cox, Julia, Patone, Martina, Mei, Xue W, Saatci, Defne, Dixon, Sharon, Khunti, Kamlesh, Zaccardi, Francesco, Watkinson, Peter, Shankar-Hari, Manu, Doidge, James, Harrison, David A, Griffin, Simon J, Sheikh, Aziz, Coupland, Carol A C

“…To assess the association between covid-19 vaccines and risk of thrombocytopenia and thromboembolic events in England among adults. Self-controlled case series…”
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Understanding Long-Term Outcomes Following Sepsis: Implications and Challenges by Shankar-Hari, Manu, Rubenfeld, Gordon D.

“…Sepsis is life-threating organ dysfunction due to infection. Incidence of sepsis is increasing and the short-term mortality is improving, generating more…”
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) by Singer, Mervyn, Deutschman, Clifford S, Seymour, Christopher Warren, Shankar-Hari, Manu, Annane, Djillali, Bauer, Michael, Bellomo, Rinaldo, Bernard, Gordon R, Chiche, Jean-Daniel, Coopersmith, Craig M, Hotchkiss, Richard S, Levy, Mitchell M, Marshall, John C, Martin, Greg S, Opal, Steven M, Rubenfeld, Gordon D, van der Poll, Tom, Vincent, Jean-Louis, Angus, Derek C

“…IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in…”
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Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex by Patone, Martina, Mei, Xue W., Handunnetthi, Lahiru, Dixon, Sharon, Zaccardi, Francesco, Shankar-Hari, Manu, Watkinson, Peter, Khunti, Kamlesh, Harnden, Anthony, Coupland, Carol A.C., Channon, Keith M., Mills, Nicholas L., Sheikh, Aziz, Hippisley-Cox, Julia

“…Myocarditis is more common after severe acute respiratory syndrome coronavirus 2 infection than after COVID-19 vaccination, but the risks in younger people and…”
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Major surgery and the immune system: from pathophysiology to treatment by Shankar Hari, Manu, Summers, Charlotte

“…The purpose of this review is to provide an overview of the immune response to major surgery, and the ways in which it may be modulated to improve…”
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The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity by Osuchowski, Marcin F, Winkler, Martin S, Skirecki, Tomasz, Cajander, Sara, Shankar-Hari, Manu, Lachmann, Gunnar, Monneret, Guillaume, Venet, Fabienne, Bauer, Michael, Brunkhorst, Frank M, Weis, Sebastian, Garcia-Salido, Alberto, Kox, Matthijs, Cavaillon, Jean-Marc, Uhle, Florian, Weigand, Markus A, Flohé, Stefanie B, Wiersinga, W Joost, Almansa, Raquel, de la Fuente, Amanda, Martin-Loeches, Ignacio, Meisel, Christian, Spinetti, Thibaud, Schefold, Joerg C, Cilloniz, Catia, Torres, Antoni, Giamarellos-Bourboulis, Evangelos J, Ferrer, Ricard, Girardis, Massimo, Cossarizza, Andrea, Netea, Mihai G, van der Poll, Tom, Bermejo-Martín, Jesús F, Rubio, Ignacio

“…The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight…”
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Antimicrobial Efficacy of Trushield™ Gloves: an In vitro Experimentation-Based Review by Shankar, Manu, Ali, Shahzad Marghoob, Gupta, Mahesh, Moharana, Ashok Kumar, TS, Deepak

“…Wearing gloves in hospital setting protect the public and healthcare workers from pathogen transmission and associated diseases. Recently, the concept of…”
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Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study by Wilson, Julie K, Zhao, Yuan, Singer, Mervyn, Spencer, Jo, Shankar-Hari, Manu

“…Sepsis remains a major cause of mortality in critical care, for which specific treatments are lacking. The dysregulated response to infection seen in sepsis…”
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Towards a biological definition of ARDS: are treatable traits the solution? by Bos, Lieuwe D. J., Laffey, John G., Ware, Lorraine B., Heijnen, Nanon F. L., Sinha, Pratik, Patel, Brijesh, Jabaudon, Matthieu, Bastarache, Julie A., McAuley, Daniel F., Summers, Charlotte, Calfee, Carolyn S., Shankar-Hari, Manu

“…The pathophysiology of acute respiratory distress syndrome (ARDS) includes the accumulation of protein-rich pulmonary edema in the air spaces and interstitial…”
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Retroperitoneal Bronchogenic Cyst: A Rare Case Study by Sinha, Vikash, Nandi, Partha, Shankar, Manu, Sardana, Nitin

“…Bronchogenic cyst usually presents along the tracheobronchial tree. Rarely, it is found inside peritoneal cavity. Here is a case of 30-year-old man who…”
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To identify the risk factors associated with development of anterior abdominal wall hernia by Prasad, Shobhit Kumar, Joshi, Richa, Kumar, Mohnish, Shankar, Manu

“…Background : numerous risk factors for the development of hernia have been identified, including abnormal collagen fiber organization and increased…”
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Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies by Shankar-Hari, Manu, Ambler, Michael, Mahalingasivam, Viyaasan, Jones, Andrew, Rowan, Kathryn, Rubenfeld, Gordon D

“…In addition to acute hospital mortality, sepsis is associated with higher risk of death following hospital discharge. We assessed the strength of…”
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Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant by Graham, Carl, Seow, Jeffrey, Huettner, Isabella, Khan, Hataf, Kouphou, Neophytos, Acors, Sam, Winstone, Helena, Pickering, Suzanne, Galao, Rui Pedro, Dupont, Liane, Lista, Maria Jose, Jimenez-Guardeño, Jose M., Laing, Adam G., Wu, Yin, Joseph, Magdalene, Muir, Luke, van Gils, Marit J., Ng, Weng M., Duyvesteyn, Helen M.E., Zhao, Yuguang, Bowden, Thomas A., Shankar-Hari, Manu, Rosa, Annachiara, Cherepanov, Peter, McCoy, Laura E., Hayday, Adrian C., Neil, Stuart J.D., Malim, Michael H., Doores, Katie J.

“…Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target…”
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A Rare Case of Epididymal Cyst Due to Schistosomiasis by Sinha, Vikash, Shankar, Manu, Sardana, Nitin, Aggarwal, Riti

“…Schistosomal epididymitis is a very rare condition. Worldwide, very few cases have been reported, especially in India. Here is a case of schistosomal…”
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International variation in the management of severe COVID-19 patients by Azoulay, Elie, de Waele, Jan, Ferrer, Ricard, Staudinger, Thomas, Borkowska, Marta, Povoa, Pedro, Iliopoulou, Katerina, Artigas, Antonio, Schaller, Stefan J, Shankar-Hari, Manu, Pellegrini, Mariangela, Darmon, Michael, Kesecioglu, Jozef, Cecconi, Maurizio

“…There is little evidence to support the management of severe COVID-19 patients. To document this variation in practices, we performed an online survey (April…”
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Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial by Boyle, Andrew James, Ferris, Peter, Bradbury, Ian, Conlon, John, Shankar-Hari, Manu, Rogers, Angela J, O'Kane, Cecilia M, McAuley, Daniel F

“…Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with…”
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Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials by Santhakumaran, Shalini, Gordon, Anthony, Prevost, A Toby, O'Kane, Cecilia, McAuley, Daniel F, Shankar-Hari, Manu

“…Randomised controlled trials (RCTs) enrolling patients with sepsis or acute respiratory distress syndrome (ARDS) generate heterogeneous trial populations…”
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