Search Results - "Shankar, J"

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease by Chinta, Shankar J., Woods, Georgia, Demaria, Marco, Rane, Anand, Zou, Ying, McQuade, Amanda, Rajagopalan, Subramanian, Limbad, Chandani, Madden, David T., Campisi, Judith, Andersen, Julie K.

“…Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed…”
Get full text

Cellular senescence and the aging brain by Chinta, Shankar J., Woods, Georgia, Rane, Anand, Demaria, Marco, Campisi, Judith, Andersen, Julie K.

“…Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of mitotically competent cells to prevent malignant transformation…”
Get full text

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo by Chinta, Shankar J., Mallajosyula, Jyothi K., Rane, Anand, Andersen, Julie K.

“…▶ α-Syn physically localizes to dopaminergic mitochondria in vivo and impacts on mitochondrial function. ▶ Localization coincides with a selective age-related…”
Get full text

Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease by Rajagopalan, Subramanian, Rane, Anand, Chinta, Shankar J, Andersen, Julie K

“…We previously reported that pharmacological inhibition of a class of enzymes known as prolyl hydroxylase domain proteins (PHDs) has neuroprotective effects in…”
Get full text

Redox imbalance in Parkinson's disease by Chinta, Shankar J., Andersen, Julie K.

“…Parkinson's disease (PD) is an adult-onset neurodegenerative disorder characterized by preferential loss of dopaminergic neurons in an area of the midbrain…”
Get full text

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function by Anand, Nikhita, Holcom, Angelina, Broussalian, Michael, Schmidt, Minna, Chinta, Shankar J., Lithgow, Gordon J., Andersen, Julie K., Chamoli, Manish

“…Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS…”
Get full text

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease by Siddiqui, Almas, Chinta, Shankar J., Mallajosyula, Jyothi K., Rajagopolan, Subramanian, Hanson, Ingrid, Rane, Anand, Melov, Simon, Andersen, Julie K.

“…Alpha-synuclein has been reported to be present in the nucleus and levels enhanced by oxidative stress. Herein, we sought to investigate the mechanistic role…”
Get full text

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion by Swayampakula, M, McDonald, P C, Vallejo, M, Coyaud, E, Chafe, S C, Westerback, A, Venkateswaran, G, Shankar, J, Gao, G, Laurent, E M N, Lou, Y, Bennewith, K L, Supuran, C T, Nabi, I R, Raught, B, Dedhar, S

“…Carbonic anhydrase IX (CAIX) is a hypoxia inducible factor 1-induced, cell surface pH regulating enzyme with an established role in tumor progression and…”
Get full text

Pirfenidone regulates LPS mediated activation of neutrophils by Evani, Shankar J., Karna, S. L. Rajasekhar, Seshu, Janakiram, Leung, Kai P.

“…Excessive inflammation or its absence may result in impaired wound healing. Neutrophils are among the first innate immune cells to arrive at the injury site…”
Get full text

Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin by Siddiqui, Almas, Bhaumik, Dipa, Chinta, Shankar J, Rane, Anand, Rajagopalan, Subramanian, Lieu, Christopher A, Lithgow, Gordon J, Andersen, Julie K

“…Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it ubiquitinates outer mitochondrial membrane proteins, initiating…”
Get full text

An inducible MAO-B mouse model of Parkinson’s disease: a tool towards better understanding basic disease mechanisms and developing novel therapeutics by Chamoli, Manish, Chinta, Shankar J., Andersen, Julie K.

“…Several studies have suggested that increases in astrocytic monoamine oxidase B (MAO-B) levels in conjunction with Parkinson’s disease (PD) may contribute to…”
Get full text

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease by Andersen, Julie K., Lithgow, Gordon J., Angeli, Suzanne, Rane, Anand, Leonoudakis, Dmitri, Chinta, Shankar J.

“…Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several…”
Get full text

MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology by Mallajosyula, Jyothi K, Kaur, Deepinder, Chinta, Shankar J, Rajagopalan, Subramanian, Rane, Anand, Nicholls, David G, Di Monte, Donato A, Macarthur, Heather, Andersen, Julie K

“…Age-related increases in monoamine oxidase B (MAO-B) may contribute to neurodegeneration associated with Parkinson's disease (PD). The MAO-B inhibitor…”
Get full text

CT perfusion for confirmation of brain death by Shankar, J J S, Vandorpe, R

“…For pronouncing brain death, unlike CTP, the 2-phase CTA gives no functional information and is limited by inadvertent delay of the second acquisition, which…”
Get full text

Editorial: Role of Senescence in Neurodegenerative Diseases by Tüzer, Ferit, Chinta, Shankar J, Viel, Tania Araujo

“…Editorial on the Research Topic Role of Senescence in Neurodegenerative Diseases Cellular senescence is permanent cell cycle arrest resulting from persistent…”
Get full text

Age-related behavioral phenotype of an astrocytic monoamine oxidase-B transgenic mouse model of Parkinson's disease by Lieu, Christopher A, Chinta, Shankar J, Rane, Anand, Andersen, Julie K

“…We have previously shown that increases in astrocytic monoamine oxidase-B (MAO-B) expression, mimicking that which occurs with aging and in neurodegenerative…”
Get full text

Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinson's disease are attenuated by restoration of PGC1alpha by Siddiqui, Almas, Rane, Anand, Rajagopalan, Subramanian, Chinta, Shankar J, Andersen, Julie K

“…Abstract Loss of parkin E3 ligase activity as a result of parkin gene mutation in rare familial forms of Parkinson ' s disease (PD) has been shown to be…”
Get full text

Monocytes mediate metastatic breast tumor cell adhesion to endothelium under flow by Evani, Shankar J., Prabhu, Rajesh G., Gnanaruban, V., Finol, Ender A., Ramasubramanian, Anand K.

“…Endothelial adhesion is necessary for the hematogenous dissemination of tumor cells. However, the metastatic breast tumor cell MDA‐MB‐231 does not bind to the…”
Get full text

Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: Implications for Parkinson's disease by Chinta, Shankar J., Andersen, Julie K.

“…The pathogenesis underlying the selective degeneration of nigral dopaminergic neurons in Parkinson's disease is not fully understood but several lines of…”
Get full text

A guide to senolytic intervention in neurodegenerative disease by Lee, Suckwon, Wang, Ellen Y., Steinberg, Alexandra B., Walton, Chaska C., Chinta, Shankar J., Andersen, Julie K.

“…•Evidence suggests that senescent cell killing by senolytic compounds may be a new intervention in neurodegeneration.•Senolytics differ on their mechanism of…”
Get full text