Search Results - "Shank, P"

Molecular Pharmacodynamics, Clinical Therapeutics, and Pharmacokinetics of Topiramate by Shank, Richard P., Maryanoff, Bruce E.

“…Topiramate (TPM; TOPAMAX®) is a broad‐spectrum antiepileptic drug (AED) that is approved in many world markets for preventing or reducing the frequency of…”
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An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action by Shank, Richard P., Gardocki, Joseph F., Streeter, Anthony J., Maryanoff, Bruce E.

“…In this overview, we discuss the discovery and development of topiramate (TPM) as an anticonvulsant, including notable aspects of its chemical, biologic, and…”
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Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes by Dodgson, Susanna J., Shank, Richard P., Maryanoff, Bruce E.

“…Purpose: This study investigated the effectiveness of topiramate (TPM) as an inhibitor of six isozymes of carbonic anhydrase (CA). Methods: The inhibition…”
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Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic by Raffa, R B, Friderichs, E, Reimann, W, Shank, R P, Codd, E E, Vaught, J L

“…Tramadol hydrochloride produced dose-related antinociception in mouse abdominal constriction [ED50 = 1.9 (1.2-2.6) mg/kg i.p.], hot-plate [48 degrees C, ED50 =…”
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Assessment of fungal diversity using terminal restriction fragment (TRF) pattern analysis: comparison of 18S and ITS ribosomal regions by Lord, N.S., Kaplan, C.W., Shank, P., Kitts, C.L., Elrod, S.L.

“…Abstract Assessment of fungal diversity in environmental samples is currently a challenge. Several recently developed molecular methods offer new avenues for…”
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Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception by Codd, E E, Shank, R P, Schupsky, J J, Raffa, R B

“…Although it is well established that the analgesic effects of morphine are mediated by opioid receptors, previous studies have shown that some opioids…”
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Assessment of fungal diversity using terminal restriction fragment (TRF) pattern analysis: comparison of 18S and ITS ribosomal regions by Lord, N.S, Kaplan, C.W, Shank, P, Kitts, C.L, Elrod, S.L

“…Assessment of fungal diversity in environmental samples is currently a challenge. Several recently developed molecular methods offer new avenues for…”
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Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol by Raffa, R B, Friderichs, E, Reimann, W, Shank, R P, Codd, E E, Vaught, J L, Jacoby, H I, Selve, N

“…The explanation for the co-existence of opioid and nonopioid components of tramadol-induced antinociception appears to be related to the different, but…”
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Plasma and whole blood pharmacokinetics of topiramate: the role of carbonic anhydrase by Shank, Richard P., Doose, Dennis R., Streeter, Anthony J., Bialer, Meir

“…Topiramate (TPM) is a broad-spectrum antiepileptic drug with various mechanisms of action including an inhibitory effect on some isozymes of carbonic anhydrase…”
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Topiramate: preclinical evaluation of structurally novel anticonvulsant by Shank, R P, Gardocki, J F, Vaught, J L, Davis, C B, Schupsky, J J, Raffa, R B, Dodgson, S J, Nortey, S O, Maryanoff, B E

“…Topiramate [TPM, 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] (RWJ-17021-000, formerly McN-4853) is a structurally novel antiepileptic…”
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Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives by Maryanoff, Bruce E., Costanzo, Michael J., Nortey, Samuel O., Greco, Michael N., Shank, Richard P., Schupsky, James J., Ortegon, Marta P., Vaught, Jeffry L.

“…We have explored the structure−activity relationship (SAR) surrounding the clinically efficacious antiepileptic drug topiramate (1), a unique sugar sulfamate…”
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Comparison of Sulfamate and Sulfamide Groups for the Inhibition of Carbonic Anhydrase-II by Using Topiramate as a Structural Platform by Maryanoff, Bruce E, McComsey, David F, Costanzo, Michael J, Hochman, Coralie, Smith-Swintosky, Virginia, Shank, Richard P

“…This paper examines the relative effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II). Topiramate (1) and its…”
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Cerebral metabolic compartmentation as revealed by nuclear magnetic resonance analysis of D-[1-13C]glucose metabolism by Shank, R P, Leo, G C, Zielke, H R

“…Nuclear magnetic resonance (NMR) was used to study the metabolic pathways involved in the conversion of glucose to glutamate, gamma-aminobutyrate (GABA),…”
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2,3-dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides : Small molecule non-peptide antagonists of the human galanin hGAL-1 receptor by SCOTT, M. K, ROSS, T. M, LEE, D. H. S, WANG, H.-Y, SHANK, R. P, WILD, K. D, DAVIS, C. B, CROOKE, J. J, POTOCKI, A. C, REITZ, A. B

“…The neuropeptide galanin modulates several physiological functions such as cognition, learning, feeding behavior, and depression, probably via the galanin 1…”
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Topiramate promotes neurite outgrowth and recovery of function after nerve injury by Smith-Swintosky, Virginia L, Zhao, Boyu, Shank, Richard P, Plata-Salaman, Carlos R

“…Topiramate is a structurally novel neurotherapeutic agent with a unique combination of pharmacological properties and currently is available in most world…”
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Topiramate monotherapy in epilepsy and migraine prevention by SILBERSTEIN, Stephen D, BEN-MENACHEM, Elinor, SHANK, Richard P, WIEGAND, Frank

“…The purposes of this review were to assess the efficacy of topiramate as monotherapy for epilepsy and migraine prevention, describe how it should be used, and…”
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Redesigning Channel-Forming Peptides: Amino Acid Substitutions that Enhance Rates of Supramolecular Self-Assembly and Raise Ion Transport Activity by Shank, Lalida P., Broughman, James R., Takeguchi, Wade, Cook, Gabriel, Robbins, Ashley S., Hahn, Lindsey, Radke, Gary, Iwamoto, Takeo, Schultz, Bruce D., Tomich, John M.

“…Three series of 22-residue peptides derived from the transmembrane M2 segment of the glycine receptor α1-subunit (M2GlyR) have been designed, synthesized, and…”
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Distinct Structural Elements That Direct Solution Aggregation and Membrane Assembly in the Channel-Forming Peptide M2GlyR by Broughman, James R, Shank, Lalida P, Takeguchi, Wade, Schultz, Bruce D, Iwamoto, Takeo, Mitchell, Kathy E, Tomich, John M

“…Restoration of chloride conductance via the introduction of an anion selective pore, formed by a channel-forming peptide, has been hypothesized as a novel…”
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5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic by Dubinsky, Barry, Vaidya, Anil H, Rosenthal, Daniel I, Hochman, Coralie, Crooke, Jeffrey J, DeLuca, Samantha, DeVine, Ann, Cheo-Isaacs, Cathy T, Carter, Alexandre R, Jordan, Alfonzo D, Reitz, Allen B, Shank, Richard P

“…5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5] imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide) (RWJ-51204) binds selectively and with high…”
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Amyloid Peptide Aβ1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors by Wang, Hoau‐Yan, Lee, Daniel H. S., Davis, Coralie B., Shank, Richard P.

“…: We have recently reported evidence that a very high affinity interaction between the β‐amyloid peptide Aβ1‐42 and the α7 nicotinic acetylcholine receptor…”
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