Search Results - "Shang, Yongfeng"

Estrogen and cancer by Liang, Jing, Shang, Yongfeng

“…Estrogen exhibits a broad spectrum of physiological functions ranging from regulation of the menstrual cycle and reproduction to modulation of bone density,…”
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Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis by Wang, Yan, Shang, Yongfeng

“…Epithelial–mesenchymal transition (EMT) is vital for morphogenesis during embryonic development and is also critical for the conversion of early stage tumors…”
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SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability by Li, Lei, Shi, Lan, Yang, Shangda, Yan, Ruorong, Zhang, Di, Yang, Jianguo, He, Lin, Li, Wanjin, Yi, Xia, Sun, Luyang, Liang, Jing, Cheng, Zhongyi, Shi, Lei, Shang, Yongfeng, Yu, Wenhua

“…Although SIRT7 is a member of sirtuin family proteins that are described as NAD + -dependent class III histone deacetylases, the intrinsic enzymatic activity…”
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USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair by Ting, Xia, Xia, Lu, Yang, Jianguo, He, Lin, Si, Wenzhe, Shang, Yongfeng, Sun, Luyang

“…Abstract How chromatin dynamics is regulated to ensure efficient DNA repair remains to be understood. Here, we report that the ubiquitin-specific protease…”
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BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer by Liu, Beibei, Liu, Xinhua, Han, Lulu, Chen, Xing, Wu, Xiaodi, Wu, Jiajing, Yan, Dong, Wang, Yue, Liu, Shumeng, Shan, Lin, Zhang, Yu, Shang, Yongfeng

“…BRD4 is well known for its role in super-enhancer organization and transcription activation of several prominent oncogenes including and As such, BRD4…”
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Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis by Liu, Shumeng, Yu, Huajing, Liu, Yongqing, Liu, Xinhua, Zhang, Yu, Bu, Chen, Yuan, Shuai, Chen, Zhe, Xie, Guojia, Li, Wanjin, Xu, Bosen, Yang, Jianguo, He, Lin, Jin, Tong, Xiong, Yundong, Sun, Luyang, Liu, Xiaohui, Han, Chunsheng, Cheng, Zhongyi, Liang, Jing, Shang, Yongfeng

“…Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with active transcription in mammalian cells. Here we report that the…”
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Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis by Wang, Qian, Ma, Shuai, Song, Nan, Li, Xin, Liu, Ling, Yang, Shangda, Ding, Xiang, Shan, Lin, Zhou, Xing, Su, Dongxue, Wang, Yue, Zhang, Qi, Liu, Xinhua, Yu, Na, Zhang, Kai, Shang, Yongfeng, Yao, Zhi, Shi, Lei

“…The histone demethylase PHF8 has been implicated in multiple pathological disorders, including X-linked mental retardation and tumorigenesis. However, it is…”
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Molecular Determinants for the Tissue Specificity of SERMs by Shang, Yongfeng, Brown, Myles

“…Selective estrogen receptor modulators (SERMs) mimic estrogen action in certain tissues while opposing it in others. The therapeutic effectiveness of SERMs…”
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LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer by Wang, Yan, Zhang, Hua, Chen, Yupeng, Sun, Yimin, Yang, Fen, Yu, Wenhua, Liang, Jing, Sun, Luyang, Yang, Xiaohan, Shi, Lei, Li, Ruifang, Li, Yanyan, Zhang, Yu, Li, Qian, Yi, Xia, Shang, Yongfeng

“…Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report…”
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USP9X regulates centrosome duplication and promotes breast carcinogenesis by Li, Xin, Song, Nan, Liu, Ling, Liu, Xinhua, Ding, Xiang, Song, Xin, Yang, Shangda, Shan, Lin, Zhou, Xing, Su, Dongxue, Wang, Yue, Zhang, Qi, Cao, Cheng, Ma, Shuai, Yu, Na, Yang, Fuquan, Wang, Yan, Yao, Zhi, Shang, Yongfeng, Shi, Lei

“…Defective centrosome duplication is implicated in microcephaly and primordial dwarfism as well as various ciliopathies and cancers. Yet, how the centrosome…”
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Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis by Si, Wenzhe, Huang, Wei, Zheng, Yu, Yang, Yang, Liu, Xujun, Shan, Lin, Zhou, Xing, Wang, Yue, Su, Dongxue, Gao, Jie, Yan, Ruorong, Han, Xiao, Li, Wanjin, He, Lin, Shi, Lei, Xuan, Chenghao, Liang, Jing, Sun, Luyang, Wang, Yan, Shang, Yongfeng

“…How loss-of-function of GATA3 contributes to the development of breast cancer is poorly understood. Here, we report that GATA3 nucleates a transcription…”
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Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14 by Li, Qian, Shi, Lei, Gui, Bin, Yu, Wenhua, Wang, Jiamu, Zhang, Di, Han, Xiao, Yao, Zhi, Shang, Yongfeng

“…JARID1B is a member of the JmjC/ARID family of demethylases that specifically demethylates tri- and di-methylated forms of histone H3 lysine 4 (H3K4) that are…”
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Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation by Chen, Xing, Yu, Chunyu, Liu, Xinhua, Liu, Beibei, Wu, Xiaodi, Wu, Jiajing, Yan, Dong, Han, Lulu, Tang, Zifan, Yuan, Xinyi, Wang, Jianqiu, Wang, Yue, Liu, Shumeng, Shan, Lin, Shang, Yongfeng

“…How the carbohydrate binding protein galectin-3 might act as a diabetogenic and tumorogenic factor remains to be investigated. Here we report that…”
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Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis by Shi, Lei, Sun, Luyang, Li, Qian, Liang, Jing, Yu, Wenhua, Yi, Xia, Yang, Xiaohan, Li, Yanyan, Han, Xiao, Zhang, Yu, Xuan, Chenghao, Yao, Zhi, Shang, Yongfeng

“…It is well-documented that the methylation of histone H3 lysine 4 (H3K4) and of H3K9 are mutually exclusive, an epigenetic phenomenon conserved from yeast to…”
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Histone demethylase KDM5B is a key regulator of genome stability by Li, Xin, Liu, Ling, Yang, Shangda, Song, Nan, Zhou, Xing, Gao, Jie, Na Yu, Shan, Lin, Wang, Qian, Liang, Jing, Xuan, Chenghao, Wang, Yan, Shang, Yongfeng, Lei Shi

“…Maintenance of genomic stability is essential for normal organismal development and is vital to prevent diseases such as cancer. As genetic information is…”
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JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation by Wang, Feng, He, Lin, Huangyang, Peiwei, Liang, Jing, Si, Wenzhe, Yan, Ruorong, Han, Xiao, Liu, Shumeng, Gui, Bin, Li, Wanjin, Miao, Di, Jing, Chao, Liu, Zhihua, Pei, Fei, Sun, Luyang, Shang, Yongfeng

“…Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular…”
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CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression by Liu, Yongqing, Lai, Shirong, Ma, Weining, Ke, Wei, Zhang, Chan, Liu, Shumeng, Zhang, Yu, Pei, Fei, Li, Shaoyi, Yi, Ming, Shu, Yousheng, Shang, Yongfeng, Liang, Jing, Huang, Zhuo

“…Impairment of intrinsic plasticity is involved in a range of neurological disorders such as epilepsy. However, how intrinsic excitability is regulated is still…”
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FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis by Shan, Lin, Zhou, Xing, Liu, Xinhua, Wang, Yue, Su, Dongxue, Hou, Yongqiang, Yu, Na, Yang, Chao, Liu, Beibei, Gao, Jie, Duan, Yang, Yang, Jianguo, Li, Wanjin, Liang, Jing, Sun, Luyang, Chen, Kexin, Xuan, Chenghao, Shi, Lei, Wang, Yan, Shang, Yongfeng

“…Although clinically associated with severe developmental defects, the biological function of FOXK2 remains poorly explored. Here we report that FOXK2 interacts…”
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The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry by Liu, Xujun, Si, Wenzhe, He, Lin, Yang, Jianguo, Peng, Yani, Ren, Jie, Liu, Xiaoping, Jin, Tong, Yu, Huajing, Zhang, Zihan, Cheng, Xiao, Zhang, Wenting, Xia, Lu, Huang, Yunchao, Wang, Yue, Liu, Shumeng, Shan, Lin, Zhang, Yu, Yang, Xiaohan, Li, Haixia, Liang, Jing, Sun, Luyang, Shang, Yongfeng

“…The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation of the…”
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Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis by He, Lin, Liu, Xinhua, Yang, Jianguo, Li, Wanjin, Liu, Shumeng, Liu, Xujun, Yang, Ziran, Ren, Jie, Wang, Yue, Shan, Lin, Guan, Chengjian, Pei, Fei, Lei, Liandi, Zhang, Yu, Yi, Xia, Yang, Xiaohan, Liang, Jing, Liu, Rong, Sun, Luyang, Shang, Yongfeng

“…Hyperactivation of EGFR/PI3K/AKT is a prominent feature of various human cancers. Thus, understanding how this molecular cascade is balanced is of great…”
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