Search Results - "Shanafelt, T. D."

Physician burnout: contributors, consequences and solutions by West, C. P., Dyrbye, L. N., Shanafelt, T. D.

“…Physician burnout, a work‐related syndrome involving emotional exhaustion, depersonalization and a sense of reduced personal accomplishment, is prevalent…”
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Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management by Shanafelt, T D, Ghia, P, Lanasa, M C, Landgren, O, Rawstron, A C

“…Chronic lymphocytic leukemia (CLL) and the other low-grade non-Hodgkin lymphomas are among the most common lymphoid malignancies. Recent studies suggest that…”
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The tumor suppressor axis p53/miR-34a regulates Axl expression in B-cell chronic lymphocytic leukemia: implications for therapy in p53-defective CLL patients by Boysen, J, Sinha, S, Price-Troska, T, Warner, S L, Bearss, D J, Viswanatha, D, Shanafelt, T D, Kay, N E, Ghosh, A K

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Longitudinal genome-wide analysis of patients with chronic lymphocytic leukemia reveals complex evolution of clonal architecture at disease progression and at the time of relapse by Braggio, E, Kay, N E, VanWier, S, Tschumper, R C, Smoley, S, Eckel-Passow, J E, Sassoon, T, Barrett, M, Van Dyke, D L, Byrd, J C, Jelinek, D F, Shanafelt, T D, Fonseca, R

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VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance by LEE, Y. K, SHANAFELT, T. D, BONE, N. D, STREGE, A. K, JELINEK, D. F, KAY, N. E

“…We have previously shown that chronic lymphocytic leukemia (CLL) B cells secrete vascular endothelial growth factor (VEGF) in vitro, have constitutively active…”
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CD38 expression levels in chronic lymphocytic leukemia B cells are associated with activation marker expression and differential responses to interferon stimulation by PITTNER, B. T, SHANAFELT, T. D, KAY, N. E, JELINEK, D. F

“…CD38, a surface protein whose expression increases upon normal B-cell activation, is a marker of disease aggression in B-cell chronic lymphocytic leukemia…”
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Survival of patients with clinically identified monoclonal B-cell lymphocytosis (MBL) relative to the age- and sex-matched general population by Shanafelt, T D, Kay, N E, Rabe, K G, Call, T G, Zent, C S, Schwager, S M, Leis, J F, Jelinek, D F, Slager, S L, Hanson, C A

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Interphase fluorescence in situ hybridization with an IGH probe is important in the evaluation of patients with a clinical diagnosis of chronic lymphocytic leukaemia by Nowakowski, G. S., Dewald, G. W., Hoyer, J. D., Paternoster, S. F., Stockero, K. J., Fink, S. R., Smoley, S. A., Remstein, E. D., Phyliky, R. L., Call, T. G., Shanafelt, T. D., Kay, N. E., Zent, C. S.

“…Summary Translocations involving IGH are common in some lymphoid malignancies but are believed to be rare in chronic lymphocytic leukaemia (CLL). To study the…”
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Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies by Shanafelt, T.D., Lee, Y.K., Call, T.G., Nowakowski, G.S., Dingli, D., Zent, C.S., Kay, N.E.

“…Green tea or its constituents have long been touted as a health promoting substance including claims it may have cancer prevention properties. We previously…”
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Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome by Barrio, S, Shanafelt, T D, Ojha, J, Chaffee, K G, Secreto, C, Kortüm, K M, Pathangey, S, Van-Dyke, D L, Slager, S L, Fonseca, R, Kay, N E, Braggio, E

“…High-count monoclonal B-cell lymphocytosis (MBL) is an asymptomatic expansion of clonal B cells in the peripheral blood without other manifestations of chronic…”
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Dynamics of microvesicle generation in B-cell chronic lymphocytic leukemia: implication in disease progression by Boysen, J, Nelson, M, Magzoub, G, Maiti, G P, Sinha, S, Goswami, M, Vesely, S K, Shanafelt, T D, Kay, N E, Ghosh, A K

“…Previously, we reported that B-cell chronic lymphocytic leukemia (CLL) patients contained elevated levels of microvesicles (MVs). However, given the quiescent…”
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Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL): a cohort study of newly diagnosed cases compared to controls by Moreira, J, Rabe, K G, Cerhan, J R, Kay, N E, Wilson, J W, Call, T G, Leis, J F, Jelinek, D F, Schwager, S M, Bowen, D A, Hanson, C A, Slager, S L, Shanafelt, T D

“…Although the risk of progression from monoclonal B-cell lymphocytosis (MBL) to chronic lymphocytic leukemia (CLL) has been well characterized, it is unknown…”
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Burnout and Career Satisfaction Among Surgical Oncologists Compared with Other Surgical Specialties by Balch, C. M., Shanafelt, T. D., Sloan, J., Satele, D. V., Kuerer, H. M.

“…Introduction Little is known regarding the rate of burnout, career satisfaction, and quality of life (QOL) among surgical oncologists compared with other…”
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Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis by Solomon, B M, Chaffee, K G, Moreira, J, Schwager, S M, Cerhan, J R, Call, T G, Kay, N E, Slager, S L, Shanafelt, T D

“…It is unknown whether individuals with monoclonal B-cell lymphocytosis (MBL) are at risk for adverse outcomes associated with chronic lymphocytic leukemia…”
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A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients by Gentile, M, Shanafelt, T D, Cutrona, G, Molica, S, Tripepi, G, Alvarez, I, Mauro, F R, Di Renzo, N, Di Raimondo, F, Vincelli, I, Todoerti, K, Matis, S, Musolino, C, Fabris, S, Vigna, E, Levato, L, Zupo, S, Angrilli, F, Consoli, U, Festini, G, Longo, G, Cortelezzi, A, Arcari, A, Federico, M, Mannina, D, Recchia, A G, Neri, A, Kay, N E, Ferrarini, M, Morabito, F

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Validation of a vitamin D replacement strategy in vitamin D-insufficient patients with lymphoma or chronic lymphocytic leukemia by Sfeir, J G, Drake, M T, LaPlant, B R, Maurer, M J, Link, B K, Berndt, T J, Shanafelt, T D, Cerhan, J R, Habermann, T M, Feldman, A L, Witzig, T

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Reply to ‘CD49d in B-cell chronic lymphocytic leukemia: correlated expression with CD38 and prognostic relevance’ by Zucchetto et al by Pittner, B T, Shanafelt, T D, Kay, N E, Jelinek, D F

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VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance by Lee, Y K, Shanafelt, T D, Bone, N D, Strege, A K, Jelinek, D F, Kay, N E

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Ibrutinib–Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia by Shanafelt, Tait D, Wang, Xin V, Kay, Neil E, Hanson, Curtis A, O’Brien, Susan, Barrientos, Jacqueline, Jelinek, Diane F, Braggio, Esteban, Leis, Jose F, Zhang, Cong C, Coutre, Steven E, Barr, Paul M, Cashen, Amanda F, Mato, Anthony R, Singh, Avina K, Mullane, Michael P, Little, Richard F, Erba, Harry, Stone, Richard M, Litzow, Mark, Tallman, Martin

“…Patients 70 years of age or younger with previously untreated CLL were randomly assigned to receive ibrutinib plus rituximab or chemoimmunotherapy with…”
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Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine by Shanafelt, Tait D., Lee, Yean K., Bone, Nancy D., Strege, Ann K., Narayanan, Ven L., Sausville, Edward A., Geyer, Susan M., Kaufmann, Scott H., Kay, Neil E.

“…B-cell chronic lymphocytic leukemia (CLL) is characterized by accumulation of clonal lymphocytes resistant to apoptosis. We evaluated the ability of the…”
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