Search Results - "Shan, Xindi"

Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway by Wang, Wei, Wu, Jiandong, Zhang, Xiaoshuang, Hao, Cui, Zhao, Xiaoliang, Jiao, Guangling, Shan, Xindi, Tai, Wenjing, Yu, Guangli

“…Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein,…”
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Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota by Bergstrom, Kirk, Shan, Xindi, Casero, David, Batushansky, Albert, Lagishetty, Venu, Jacobs, Jonathan P, Hoover, Christopher, Kondo, Yuji, Shao, Bojing, Gao, Liang, Zandberg, Wesley, Noyovitz, Benjamin, McDaniel, J Michael, Gibson, Deanna L, Pakpour, Sepideh, Kazemian, Negin, McGee, Samuel, Houchen, Courtney W, Rao, Chinthalapally V, Griffin, Timothy M, Sonnenburg, Justin L, McEver, Rodger P, Braun, Jonathan, Xia, Lijun

“…Colon mucus segregates the intestinal microbiota from host tissues, but how it organizes to function throughout the colon is unclear. In mice, we found that…”
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Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer by Liu, Fei, Fu, Jianxin, Bergstrom, Kirk, Shan, Xindi, McDaniel, J Michael, McGee, Samuel, Bai, Xia, Chen, Weichang, Xia, Lijun

“…Core 1-derived mucin-type O-glycans (O-glycans) are a major component of gastric mucus with an unclear role. To address this, we generated mice lacking gastric…”
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In vitro and in vivo hypoglycemic effects of brown algal fucoidans by Shan, Xindi, Liu, Xin, Hao, Jiejie, Cai, Chao, Fan, Fei, Dun, Yunlou, Zhao, Xiaoliang, Liu, Xiaoxiao, Li, Chunxia, Yu, Guangli

“…The inhibition of α-glucosidase is an effective therapeutic approach for type 2 diabetes mellitus that involves decreasing postprandial hyperglycemia. In the…”
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Dclk1 in tuft cells promotes inflammation-driven epithelial restitution and mitigates chronic colitis by Yi, Jun, Bergstrom, Kirk, Fu, Jianxin, Shan, Xindi, McDaniel, J. Michael, McGee, Samuel, Qu, Dongfeng, Houchen, Courtney W., Liu, Xiaowei, Xia, Lijun

“…Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by defective intestinal barrier integrity toward the microbiota and epithelial…”
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Fucoidan from Ascophyllum nodosum Suppresses Postprandial Hyperglycemia by Inhibiting Na + /Glucose Cotransporter 1 Activity by Shan, Xindi, Wang, Xueliang, Jiang, Hao, Cai, Chao, Hao, Jiejie, Yu, Guangli

“…We previously demonstrated that fucoidan with a type II structure inhibited postprandial hyperglycemia by suppressing glucose uptake, but the mechanism remains…”
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Anti-Metabolic Syndrome Effects of Fucoidan from Fucus vesiculosus via Reactive Oxygen Species-Mediated Regulation of JNK, Akt, and AMPK Signaling by Wang, Xueliang, Shan, Xindi, Dun, Yunlou, Cai, Chao, Hao, Jiejie, Li, Guoyun, Cui, Kaiyun, Yu, Guangli

“…Recent studies have reported that dietary fiber improved metabolic syndrome (MetS). However, the effects of fucoidans on MetS were still not clear. In this…”
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C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression by Wan, Yangu, Adair, Kareena, Herrmann, Anne, Shan, Xindi, Xia, Lijun, Duckworth, Carrie A., Yu, Lu-Gang

“…Although most cell membrane proteins are modified by glycosylation, our understanding of the role and actions of protein glycosylation is still very limited…”
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Extraction, Isolation, Structural Characterization and Anti-Tumor Properties of an Apigalacturonan-Rich Polysaccharide from the Sea Grass Zostera caespitosa Miki by Lv, Youjing, Shan, Xindi, Zhao, Xia, Cai, Chao, Zhao, Xiaoliang, Lang, Yinzhi, Zhu, He, Yu, Guangli

“…An apigalacturonan (AGA)-rich polysaccharide, ZCMP, was isolated from the sea grass Zostera caespitosa Miki. The depolymerized fragments derived from ZCMP were…”
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Structural Characterization and Interaction with RCA120 of a Highly Sulfated Keratan Sulfate from Blue Shark (Prionace glauca) Cartilage by Li, Qinying, Li, Guoyun, Zhao, Xiaoliang, Shan, Xindi, Cai, Chao, Zhao, Jing, Zhang, Fuming, Linhardt, Robert, Yu, Guangli

“…As an important glycosaminoglycan, keratan sulfate (KS) mainly exists in corneal and cartilage, possessing various biological activities. In this study, we…”
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Carrageenan-induced colitis is associated with decreased population of anti-inflammatory bacterium, Akkermansia muciniphila, in the gut microbiota of C57BL/6J mice by Shang, Qingsen, Sun, Weixia, Shan, Xindi, Jiang, Hao, Cai, Chao, Hao, Jiejie, Li, Guoyun, Yu, Guangli

“…•Oral administration of carrageenan induces colitis in the colon of C57BL/6J mice.•The effect of carrageenan on the gut microbiota was studied using…”
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Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae by Shang, Qingsen, Shan, Xindi, Cai, Chao, Hao, Jiejie, Li, Guoyun, Yu, Guangli

“…Recently, fucoidan has been proposed as a potential prebiotic agent for functional food and pharmaceutical development. However, while previous studies…”
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Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications by Ding, Lang, Shan, Xindi, Zhao, Xiaoliang, Zha, Hualian, Chen, Xiaoyu, Wang, Jianjun, Cai, Chao, Wang, Xiaojiang, Li, Guoyun, Hao, Jiejie, Yu, Guangli

“…The purpose of this study was to develop a promising wound dressing. Though chitosan cross-linked with genipin has been widely used as biomaterials, with the…”
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A β-glucan from Durvillaea Antarctica has immunomodulatory effects on RAW264.7 macrophages via toll-like receptor 4 by Yang, Yi, Zhao, Xiaoliang, Li, Jia, Jiang, Hao, Shan, Xindi, Wang, Ya, Ma, Wenbang, Hao, Jiejie, Yu, Guangli

“…•The structure of a novel polysaccharide extracted from Durvillaea Antarctica (BG136) is identified as β1,3/1,6-glucan.•BG136 promotes cytokine production,…”
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Antithrombotic activities of fucosylated chondroitin sulfates and their depolymerized fragments from two sea cucumbers by Liu, Xiaoxiao, Hao, Jiejie, Shan, Xindi, Zhang, Xiao, Zhao, Xiaoliang, Li, Qinying, Wang, Xiaojiang, Cai, Chao, Li, Guoyun, Yu, Guangli

“…•FCSs structures from two sea cucumbers were characterized.•Anticoagulant and anti-thrombotic activity were compared in vitro and in vivo.•FCSs had similar…”
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Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens by Cui, Kaiyun, Tai, Wenjing, Shan, Xindi, Hao, Jiejie, Li, Guoyun, Yu, Guangli

“…The sulfated polysaccharide NP2 was isolated and purified from Nemacystus decipiens, the structure and antithrombotic activity of NP2 was further studied. NP2…”
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Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice by Shi, Huiping, Gao, Liang, Kirby, Nicole, Shao, Bojing, Shan, Xindi, Kudo, Mariko, Silasi, Robert, McDaniel, John Michael, Zhou, Meixiang, McGee, Samuel, Jing, Wei, Lupu, Florea, Cleuren, Audrey, George, James N., Xia, Lijun

“…•Single-cell RNA sequencing and spatial transcriptomics reveal transcriptionally distinct hepatic macrophage populations in SCA mice.•Efficient clearance of…”
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Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice by Shi, Huiping, Song, Jianhua, Gao, Liang, Shan, Xindi, Panicker, Sumith R, Yao, Longbiao, McDaniel, Michael, Zhou, Meixiang, McGee, Samuel, Zhong, Hui, Griffin, Courtney T, Xia, Lijun, Shao, Bojing

“…Integrin-regulated monocyte recruitment and cellular responses of monocyte-derived macrophages are critical for the pathogenesis of atherosclerosis. In the…”
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Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP by Shao, Bojing, Hoover, Christopher, Shi, Huiping, Kondo, Yuji, Lee, Robert H., Chen, Junmei, Shan, Xindi, Song, Jianhua, McDaniel, J. Michael, Zhou, Meixiang, McGee, Samuel, Vanhoorelbeke, Karen, Bergmeier, Wolfgang, López, José A., George, James N., Xia, Lijun

“…Microvascular thrombosis in patients with thrombotic thrombocytopenic purpura (TTP) is initiated by GPIbα-mediated platelet binding to von Willebrand factor…”
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Ablation of Intestinal Epithelial Sialylation Predisposes to Acute and Chronic Intestinal Inflammation in Mice by Shan, Xindi, Rathore, Shipra, Kniffen, Darrek, Gao, Liang, Nitin, Letef, Clara L., Shi, Huiping, Ghosh, Sanjoy, Zandberg, Wesley, Xia, Lijun, Bergstrom, Kirk S.

“…Addition of sialic acids (sialylation) to glycoconjugates is a common capping step of glycosylation. Our study aims to determine the roles of the overall…”
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