Search Results - "Shan, Jichuan"

Dose-dependent effects of IL-17 on IL-13-induced airway inflammatory responses and airway hyperresponsiveness by Kinyanjui, Margaret W, Shan, Jichuan, Nakada, Emily M, Qureshi, Salman T, Fixman, Elizabeth D

“…The Th2 cytokine IL-13 regulates several aspects of the asthmatic phenotype, including airway inflammation, airway hyperresponsiveness, and mucus production…”
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Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation by Zhao, Hedi, Moarbes, Vanessa, Gaudreault, Véronique, Shan, Jichuan, Aldossary, Haya, Cyr, Louis, Fixman, Elizabeth D

“…Sex differences in asthma prevalence are well-documented but poorly understood. Murine models have contributed to our understanding of mechanisms that could…”
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STAT6 inhibitory peptide given during RSV infection of neonatal mice reduces exacerbated airway responses upon adult reinfection by Srinivasa, Bharat T., Restori, Katherine H., Shan, Jichuan, Cyr, Louis, Xing, Li, Lee, Soojin, Ward, Brian J., Fixman, Elizabeth D.

“…Respiratory syncytial virus (RSV)‐related hospitalization during infancy is strongly associated with the subsequent development of asthma. Early life RSV…”
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Inhibition of Experimental Allergic Airways Disease by Local Application of a Cell-Penetrating Dominant-Negative STAT-6 Peptide by McCusker, Christine T, Wang, Yufa, Shan, Jichuan, Kinyanjui, Margaret W, Villeneuve, Annie, Michael, Husheem, Fixman, Elizabeth D

“…Allergic airways disease is initiated and perpetuated by an aberrant Th2 inflammatory response regulated in part by the cytokines IL-4 and IL-13, each of which…”
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NOS 1 is required for allergen-induced expression of NOS 2 in mice by Iijima, Hiroaki, Tulic, Meri K, Duguet, Alexandre, Shan, Jichuan, Carbonara, Paolo, Hamid, Qutayba, Eidelman, David H

“…Although increased nitric oxide (NO) production in asthma is mediated largely by upregulation of the inducible form of nitric oxide synthase (iNOS, or NOS 2),…”
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STAT6-IP-Dependent Disruption of IL-33-Mediated ILC2 Expansion and Type 2 Innate Immunity in the Murine Lung by Moarbes, Vanessa, Gaudreault, Véronique, Karkout, Rami, Labrie, Lydia, Zhao, Hedi, Shan, Jichuan, Fixman, Elizabeth D

“…Recent interest has focused on innate-type cytokines as promoters of type 2 immunity and targets for drug development in asthma. IL-33 induces production of…”
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Protein nitration in chronic sinusitis and nasal polyposis: Role of eosinophils by Bernardes, Julio Freire, Shan, Jichuan, Tewfik, Marc, Hamid, Qutayba, Frenkiel, Saul, Eidelman, David H.

“…To investigate the possible role of eosinophil peroxidase (EPO) in 3-nitrotyrosine (3NT) formation. Observational study employing immunocytochemistry to assess…”
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Female-specific enhancement of eosinophil recruitment and activation in a type 2 innate inflammation model in the lung by Karkout, Rami, Gaudreault, Véronique, Labrie, Lydia, Aldossary, Haya, Azalde Garcia, Noelia, Shan, Jichuan, Fixman, Elizabeth D

“…A sex disparity in asthma prevalence and severity exists in humans. Multiple studies have highlighted the role of innate cells in shaping the adaptive immune…”
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STAT6 inhibitory peptide reduces dendritic cell migration to the lymph nodes to control Th2 adaptive immunity in the mouse lung by Lee, Soojin, Shan, Jichuan, Aldossary, Haya, Gaudreault, Véronique, Bazett, Mark, Fixman, Elizabeth D.

“…Type 2 immunity in the lung is promoted through the release of innate cytokines, including TSLP, from lung structural cells. These cytokines drive Type 2…”
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STAT6-dependent regulation of airway inflammatory responses via OX40L expression on dendritic cells (IRC4P.610) by Lee, Soojin, Shan, Jichuan, Jin, Manli, Srinivasa, Bharat, Fixman, Elizabeth

“…Abstract Epithelial and other structural cells drive Th2 responses in vivo indirectly upon TLR4 or NOD receptor stimulation and production TSLP and other…”
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Adjuvant-dependent regulation of interleukin-17 expressing γδ T cells and inhibition of Th2 responses in allergic airways disease by Nakada, Emily M, Shan, Jichuan, Kinyanjui, Margaret W, Fixman, Elizabeth D

“…Th2 immune responses are linked primarily to mild and moderate asthma, while Th17 cells, Interleukin-17A (IL-17) and neutrophilia have been implicated in more…”
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Adjuvant-dependent regulation of interleukin-17 expressing gamma delta T cells and inhibition of Th2 responses in allergic airways disease by Nakada, Emily M, Shan, Jichuan, Kinyanjui, Margaret W, Fixman, Elizabeth D

“…Background: Th2 immune responses are linked primarily to mild and moderate asthma, while Th17 cells, Interleukin-17A (IL-17) and neutrophilia have been…”
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Regulation of STAT-6 activation in ovalbumin stimulated murine splenocytes: mechanisms regulating biphasic induction (57.13) by Lee, Soojin, Shan, Jichuan, Fixman, Elizabeth

“…Abstract T cell receptor (TCR) stimulation and IL-4 receptor signaling mediate STAT-6 activation and differentiation of naïve T cells into T helper type 2…”
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In vivo regulation of IL-13 induced γδ T cell inflammatory responses by IL-17 (55.10) by Kinyanjui, Margaret, Shan, Jichuan, Fixman, Elizabeth

“…Abstract The Th2 cytokine IL-13 regulates several aspects of asthma including airway inflammation, airway hyperresponsiveness (AHR) and mucus production. The…”
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IL-13 regulates the in vivo generation of IL-17 producing T cells (163.15) by Kinyanjui, Margaret, Shan, Jichuan, Fixman, Elizabeth

“…Abstract Several features associated with allergic airways disease are regulated by the Th2 cytokine IL-13. IL-17 is also known to regulate aspects of allergic…”
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Adjuvant-dependent regulation of interleukin-17 expressing [gamma][delta] T cells and inhibition of Th2 responses in allergic airways disease by Nakada, Emily M, Shan, Jichuan, Kinyanjui, Margaret W, Fixman, Elizabeth D

“…Background Th2 immune responses are linked primarily to mild and moderate asthma, while Th17 cells, Interleukin-17A (IL-17) and neutrophilia have been…”
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Nitric oxide and collagen expression in allergic upper-airway disease by Tewfik, Marc A, Bernardes, Julio F, Shan, Jichuan, Robinson, Michelle, Frenkiel, Saul, Eidelman, David H

“…The presence of nitric oxide (NO) in high concentrations has been described in the nasal mucosa of patients with untreated allergic rhinitis. We sought to…”
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Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite by Govindaraju, Karuthapillai, Shan, Jichuan, Levesque, Kathy, Hussain, Sabah N.A., Powell, William S., Eidelman, David H.

“…To investigate peroxidase induced 3′-nitrotyrosine (3NT) formation, neutrophil derived myeloperoxidase (MPO) (0.025 μM) was directly administered to A549…”
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