Search Results - "Shamu, C E"

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus by Shamu, C. E., Walter, P.

“…The transmembrane kinase Ire1p is required for activation of the unfolded protein response (UPR), the increase in transcription of genes encoding endoplasmic…”
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Evidence for evolutionary conservation of sex-determining genes by Zarkower, David, Raymond, Christopher S, Shamu, Caroline E, Shen, Michael M, Seifert, Kelly J, Hirsch, Betsy, Hodgkin, Jonathan

“…Most metazoans occur as two sexes. Surprisingly, molecular analyses have hitherto indicated that sex-determining mechanisms differ completely between phyla…”
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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase by Cox, J S, Shamu, C E, Walter, P

“…The transcription of genes encoding soluble proteins that reside in the endoplasmic reticulum (ER) is induced when unfolded proteins accumulate in the ER…”
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Sister Chromatid Separation in Frog Egg Extracts Requires DNA Topoisomerase II Activity during Anaphase by Shamu, Caroline E., Murray, Andrew W.

“…We have produced metaphase spindles and induced them to enter anaphase in vitro. Sperm nuclei were added to frog egg extracts, allowed to replicate their DNA,…”
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Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol by Shamu, C E, Flierman, D, Ploegh, H L, Rapoport, T A, Chau, V

“…The human cytomegalovirus protein US11 induces the dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol for degradation…”
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C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons by Miller, David M, Shen, Michael M, Shamu, Caroline E, Bürglin, Thomas R, Ruvkun, Gary, Dubois, Michelle L, Ghee, Medeva, Wilson, Laura

“…The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms…”
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The Pathway of US11-Dependent Degradation of MHC Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate by Shamu, Caroline E., Story, Craig M., Rapoport, Tom A., Ploegh, Hidde L.

“…The human cytomegalovirus protein, US11, initiates the destruction of MHC class I heavy chains by targeting them for dislocation from the ER to the cytosol and…”
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Splicing: HACking into the unfolded-protein response by Shamu, Caroline E

“…Unfolded proteins in the ER of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p…”
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Splicing together the unfolded-protein response by Shamu, C E

“…Recent work has identified a transcription factor, Hac1p, in the yeast Saccharomyces cerevisiae, as a component of a pathway that signals to the nucleus the…”
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A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique by Hoffman, Gregory R, Moerke, Nathan J, Hsia, Max, Shamu, Caroline E, Blenis, John

“…The mTORC1 pathway is a central regulator of cell growth, and defective mTORC1 regulation plays a causative role in a variety of human diseases, including…”
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Measure, mine, model, and manipulate: the future for HTS and chemoinformatics? by Parker, Christian N., Shamu, Caroline E., Kraybill, Brian, Austin, Christopher P., Bajorath, Jürgen

“…‘Managing large compound collections and handling massive amounts of screening data would simply not be possible without well-designed informatics…”
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Signal transduction: Splicing together the unfolded-protein response by Shamu, Caroline E

“…Recent work has identified a transcription factor, Hac1p, in the yeast Saccharomyces cerevisiae, as a component of a pathway that signals to the nucleus the…”
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