Search Results - "Shamshoum, Hesham"

Anticancer effects of oleuropein by Shamshoum, Hesham, Vlavcheski, Filip, Tsiani, Evangelia

“…Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis. Epidemiological studies suggest that olive oil intake is associated with a…”
Get full text

Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives by Naimi, Madina, Vlavcheski, Filip, Shamshoum, Hesham, Tsiani, Evangelia

“…Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin…”
Get full text

Housing temperature affects the acute and chronic metabolic adaptations to exercise in mice by McKie, Greg L., Medak, Kyle D., Knuth, Carly M., Shamshoum, Hesham, Townsend, Logan K., Peppler, Willem T., Wright, David C.

“…Key points Mice are commonly housed at room temperatures below their thermoneutral zone meaning they are exposed to chronic thermal stress. Endurance exercise…”
Get full text

Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice by Shamshoum, Hesham, Medak, Kyle D., McKie, Greg L., Jeromson, Stewart, Hahn, Margaret K., Wright, David C.

“…Antipsychotic medications are used in the management of schizophrenia and a growing number of off-label conditions. While effective at reducing psychoses,…”
Get full text

Enhancing endogenous levels of GLP1 dampens acute olanzapine induced perturbations in lipid and glucose metabolism by Medak, Kyle D, Weber, Alyssa J, Shamshoum, Hesham, McKie, Greg L, Hahn, Margaret K, Wright, David C

“…Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and several on- and off-label conditions. While effective in…”
Get full text

The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued by cilostamide by Medak, Kyle D., McKie, Greg L., Shamshoum, Hesham, Seguin, Ian, Wright, David C.

“…Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized…”
Get full text

Attenuation of High Glucose/High Insulin‐Induced Muscle Insulin Resistance by Rosemary Extract by Shamshoum, Hesham, Tsiani, Evangelia

“…Insulin is a key hormone affecting metabolism and plays a major role in the regulation of glucose homeostasis. Skeletal muscle accounts for ~80% of…”
Get full text

Intermittent Ambient Cold Exposure Is Not an Effective Obesity Treatment in Mice Housed at Thermoneutrality by McKie, Greg, Shamshoum, Hesham, Dibe, Hana, Wright, David

“…Chronic ambient cold exposure has been regarded as a promising obesity treatment given it potently increases energy expenditure. However, few mammals are…”
Get full text

Peripheral mechanisms of acute olanzapine induced metabolic dysfunction: A review of in vivo models and treatment approaches by Shamshoum, Hesham, Medak, Kyle D., Wright, David C.

“…Antipsychotic (AP) medications are associated with an increased risk for developing metabolic side effects including weight gain, dyslipidemia, hypertension,…”
Get full text

Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality by McKie, Greg L., Medak, Kyle D., Shamshoum, Hesham, Wright, David C.

“…Increasing whole‐body energy expenditure via the pharmacological activation of uncoupling protein 1 (UCP1)‐dependent brown adipose tissue (BAT) thermogenesis…”
Get full text

GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia by Medak, Kyle D, Shamshoum, Hesham, Peppler, Willem T, Wright, David C

“…Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and a number of off-label conditions. Although effective in…”
Get more information

Rac1 supports muscle glucose uptake independently of Akt by Marko, Daniel M., Shamshoum, Hesham

Get full text

Fasting or the short‐term consumption of a ketogenic diet protects against antipsychotic‐induced hyperglycaemia in mice by Shamshoum, Hesham, Medak, Kyle D., McKie, Greg L., Hahn, Margaret K., Wright, David C.

“…Antipsychotic (AP) medications, such as olanzapine (OLZ), are used in the treatment of schizophrenia and a growing number of ‘off‐label’ conditions. A single…”
Get full text

Thermoneutral housing and preexisting obesity do not abolish the sexually dimorphic effects of olanzapine on weight gain in mice by Seguin, Ian, Medak, Kyle D., Shamshoum, Hesham, Hahn, Margaret K., Wright, David C.

“…Objective In contrast to what is seen clinically, male mice are resistant to antipsychotic‐induced obesity. This is problematic as preclinical studies…”
Get full text

CHOP is dispensable for exercise-induced increases in GDF15 by Townsend, Logan K, Medak, Kyle, Weber, Alyssa J, Dibe, Hana, Shamshoum, Hesham, Wright, David C

“…Growth differentiating factor-15 (GDF15) is expressed, and secreted, from a wide range of tissues and serves as a marker of cellular stress. A key…”
Get full text

The Deletion of AMPK β1 Worsens Glucose Tolerance and Liver Lipid Accumulation, but Doesn’t Impact the Metabolic Effects of Olanzapine in Male Mice by Shamshoum, Hesham, Ashworth, Kristen E., Medak, Kyle D., Kemp, Bruce E., Wright, David C.

“…Abstract only Second generation antipsychotic (SGA) medications, like olanzapine (OLZ), are an important component in the pharmacological management of many…”
Get full text

Acute Voluntary Wheel Running Attenuates Olanzapine‐Induced Hyperglycemia in Male Mice by Ashworth, Kristen E., Shamshoum, Hesham, Medak, Kyle D., Wright, David C.

“…Abstract only Background Olanzapine is a second‐generation antipsychotic often used in the treatment of schizophrenia and other “off‐label” conditions. Though…”
Get full text

AMPK mediates energetic stress‐induced liver GDF15 by Townsend, Logan K., Weber, Alyssa J., Day, Emily A., Shamshoum, Hesham, Shaw, Simon J., Perry, Christopher G. R., Kemp, Bruce E., Steinberg, Gregory R., Wright, David C.

“…Growth differentiating factor‐15 (GDF15) is an emerging target for the treatment of obesity and metabolic disease partly due to its ability to suppress food…”
Get full text

Examining the effects of housing temperature on mitochondrial adaptations to exercise and the browning of white adipose tissue by McKie, Greg Lawrence, Medak, Kyle D., Knuth, Carly M., Townsend, Logan K., Shamshoum, Hesham, Peppler, Willem T., Wright, David C.

“…The thermoneutral zone for small rodents is ~29–31°C and with decreases in ambient temperature below this there are consequent increases in metabolism to…”
Get full text

The absence of AMPK beta1 exacerbates the acute olanzapine‐induced hyperglycemia in female mice by Shamshoum, Hesham, Medak, Kyle D., Wojdyla, Gabriela, Peppler, Willem T., Townsend, Logan K., Kemp, Bruce E., Wright, David C.

“…Olanzapine is a second‐generation antipsychotic drug used widely in the treatment of schizophrenia. Though effective in reducing psychoses, acute olanzapine…”
Get full text