Search Results - "Shamseddine, Achraf"

Tumor Immunity and Immunotherapy for HPV-Related Cancers by Shamseddine, Achraf A, Burman, Bharat, Lee, Nancy Y, Zamarin, Dmitriy, Riaz, Nadeem

“…Human papillomavirus (HPV) infection drives tumorigenesis in the majority of cervical, oropharyngeal, anal, and vulvar cancers. Genetic and epidemiologic…”
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Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes by Shamseddine, Achraf A., Airola, Michael V., Hannun, Yusuf A.

“…Our understanding of the functions of ceramide signaling has advanced tremendously over the past decade. In this review, we focus on the roles and regulation…”
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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation by Airola, Michael V., Shanbhogue, Prajna, Shamseddine, Achraf A., Guja, Kip E., Senkal, Can E., Maini, Rohan, Bartke, Nana, Wu, Bill X., Obeid, Lina M., Garcia-Diaz, Miguel, Hannun, Yusuf A.

“…Neutral sphingomyelinase 2 (nSMase2, product of the SMPD3 gene) is a key enzyme for ceramide generation that is involved in regulating cellular stress…”
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Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases by Mohammed, Samia, Shamseddine, Achraf A, Newcomb, Benjamin, Chavez, Ronald S, Panzner, Tyler D, Lee, Allen H, Canals, Daniel, Okeoma, Chioma M, Clarke, Christopher J, Hannun, Yusuf A

“…Doxorubicin (Dox) is a widely used chemotherapy, but its effectiveness is limited by dose-dependent side effects. Although lower Dox doses reduce this risk,…”
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Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development by Rella, Antonella, Mor, Visesato, Farnoud, Amir M, Singh, Ashutosh, Shamseddine, Achraf A, Ivanova, Elitza, Carpino, Nicholas, Montagna, Maria T, Luberto, Chiara, Del Poeta, Maurizio

“…Cryptococcosis caused by Cryptococcus neoformans and Cryptococcus gattii affects a large population and is a cause of significant morbidity and mortality…”
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ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation[S] by Clarke, Christopher J., Shamseddine, Achraf A., Jacob, Joseph J., Khalife, Gabrielle, Burns, Tara A., Hannun, Yusuf A.

“…Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are…”
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A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK1‐suppressed pathway by Carroll, Brittany L., Bonica, Joseph, Shamseddine, Achraf A., Hannun, Yusuf A., Obeid, Lina M.

“…Sphingosine kinase 1 (SK1) is a lipid kinase whose activity produces sphingosine 1‐phosphate, a prosurvival lipid associated with proliferation, angiogenesis,…”
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Early Detection of Leptomeningeal Metastases Among Patients Undergoing Spinal Stereotactic Radiosurgery by Freret, Morgan E., Wijetunga, N. Ari, Shamseddine, Achraf A., Higginson, Daniel S., Schmitt, Adam M., Yamada, Yoshiya, Lis, Eric, Boire, Adrienne, Yang, Jonathan T., Xu, Amy J.

“…The management of patients with advanced solid malignancies increasingly uses stereotactic body radiation therapy (SBRT). Advanced cancer patients are at risk…”
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A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK 1‐suppressed pathway by Carroll, Brittany L., Bonica, Joseph, Shamseddine, Achraf A., Hannun, Yusuf A., Obeid, Lina M.

“…Sphingosine kinase 1 ( SK 1) is a lipid kinase whose activity produces sphingosine 1‐phosphate, a prosurvival lipid associated with proliferation,…”
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Ratio Between Positive Lymph Nodes and Total Excised Axillary Lymph Nodes as an Independent Prognostic Factor for Overall Survival in Patients with Nonmetastatic Lymph Node-Positive Breast Cancer by Hatoum, Hassan A., Jamali, Faek R., El-Saghir, Nagi S., Musallam, Khaled M., Seoud, Muhieddine, Dimassi, Hani, Abbas, Jaber, Khalife, Mohamad, Boulos, Fouad I., Tawil, Ayman N., Geara, Fadi B., Salem, Ziad, Shamseddine, Achraf A., Al-Feghali, Karine, Shamseddine, Ali I.

“…Background The status of the axillary lymph nodes in nonmetastatic lymph node-positive breast cancer (BC) patients remains the single most important…”
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Unusually young age distribution of primary hepatic leiomyosarcoma: case series and review of the adult literature by Shamseddine, Achraf, Faraj, Walid, Mukherji, Deborah, El Majzoub, Nadim, Khalife, Mohamed, Soubra, Ayman, Shamseddine, Ali

“…Primary hepatic leiomyosarcoma is a rare disease diagnosed in older aged adults with a median age of 58 and occasionally in children with a history of…”
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Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease by Faraj, Walid, Mukherji, Deborah, El Majzoub, Nadim, Shamseddine, Ali, Shamseddine, Achraf, Khalife, Mohamed

“…Primary undifferentiated embryonal sarcoma of the liver is a rare tumor with a peak incidence between the ages of 6 and 10 years. We report a case of a primary…”
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Ratio Between Positive Lymph Nodes and Total Excised Axillary Lymph Nodes as an Independent Prognostic Factor for Overall Survival in Patients with Nonmetastatic Lymph Node-Positive Breast Cancer by Hatoum, Hassan A., Jamali, Faek R., El-Saghir, Nagi S., Musallam, Khaled M., Seoud, Muhieddine, Dimassi, Hani, Abbas, Jaber, Khalife, Mohamad, Boulos, Fouad I., Tawil, Ayman N., Geara, Fadi B., Salem, Ziad, Shamseddine, Achraf A., Al-Feghali, Karine, Shamseddine, Ali I.

“…Background. The status of the axillary lymph nodes in nonmetastatic lymph node-positive breast cancer (BC) patients remains the single most important…”
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Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positive breast cancer by Hatoum, Hassan A., Jamali, Faek R., El-Saghir, Nagi S., Musallam, Khaled M., Seoud, Muhieddine, Dimassi, Hani, Abbas, Jaber, Khalife, Mohamad, Boulos, Fouad I., Tawil, Ayman N., Geara, Fadi B., Salem, Ziad, Shamseddine, Achraf A., Al-Feghali, Karine, Shamseddine, Ali I.

“…Background The status of the axillary lymph nodes in nonmetastatic lymph node-positive breast cancer (BC) patients remains the single most important…”
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Abstract P2-16-06: In-breast pathologic complete response (pCR) following neoadjuvant chemotherapy predicts nodal pCR in early stage breast cancer by Shamseddine, Achraf, Flynn, Jessica, Zhang, Zhigang, Morrow, Monica, Mueller, Boris, Gillespie, Erin, Khan, Atif, McCormick, Beryl, Cahlon, Oren, Powell, Simon, Barrio, Andrea, Braunstein, Lior Z

“…Abstract Background: With advances in neoadjuvant chemotherapy (NAC), an increasing number of breast cancer patients achieve a pathologic complete response…”
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Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies by Shamseddine, Achraf, Patel, Suchit H, Chavez, Valery, Moore, Zachary R, Adnan, Mutayyaba, Di Bona, Melody, Li, Jun, Dang, Chau T, Ramanathan, Lakshmi V, Oeffinger, Kevin C, Liu, Jennifer E, Steingart, Richard M, Piersigilli, Alessandra, Socci, Nicholas D, Chan, Angel T, Yu, Anthony F, Bakhoum, Samuel F, Schmitt, Adam M

“…Late cardiac toxicity is a potentially lethal complication of cancer therapy, yet the pathogenic mechanism remains largely unknown, and few treatment options…”
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Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer by Han, James, Zakeri, Kaveh, Raab, Gabriel, Hesse, Jennifer, Shamseddine, Achraf, Chen, Linda, Yu, Yao, Kang, Jung Julie, McBride, Sean M., Riaz, Nadeem, Tsai, C. Jillian, Gelblum, Daphna, Sherman, Eric J., Wong, Richard J., Michel, Loren, Lee, Nancy Y.

“…Background We report the outcomes of cisplatin‐ineligible HNSCC patients treated with definitive chemoradiation and concurrent carboplatin and paclitaxel…”
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Crystal structure and activation mechanism of human neutral sphingomyelinase 2 by Shanbhogue, Prajna, Airola, Michael, Shamseddine, Achraf, Guja, Kip, Maini, Rohan, Bartke, Nana, Wu, Bill, Obeid, Lina, Garcia‐Diaz, Miguel, Hannun, Yusuf

“…Abstract only Neutral sphingomyelinase 2 (nSMase2) is a magnesium‐dependent phophodiesterase that generates the bioactive sphingolipid ceramide. Ceramide is a…”
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Role and regulation of neutral sphingomyelinase-2 in response to DNA damage by Shamseddine, Achraf

“…Neutral sphingomylinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. In this thesis,…”
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