Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones

Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Althou...

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Bibliographic Details
Published in:	Iranian journal of pharmaceutical research : IJPR Vol. 10; no. 2; pp. 225 - 231
Main Authors:	Shamsa, Fazel, Foroumadi, Alireza, Shamsa, Hashim, Samadi, Nasrin, Faramarzi, Mohammad Ali, Shafiee, Abbas
Format:	Journal Article
Language:	English
Published:	Iran Shaheed Beheshti University of Medical Sciences 01-01-2011
Subjects:	Original In-vitro antibacterial activity N-substituted piperazinyl quinolones Phenanthrene derivatives Anthracene derivatives
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Summary:	Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives showed better activity in comparison with mother drugs based on molar concentration; for example, the 3-acetyl phenanthrene analogue of norfloxacin was more effective than E. coli and K. pneumonia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1735-0328 1726-6890