Search Results - "Shames, Stephanie R"

Pathogenicity and Virulence of Legionella: Intracellular replication and host response by Chauhan, Deepika, Shames, Stephanie R.

“…Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe pneumonia in humans called Legionnaires' Disease. Human disease…”
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Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions by Ngwaga, Tshegofatso, Chauhan, Deepika, Salberg, Abigail G, Shames, Stephanie R

“…Legionella pneumophila is a natural pathogen of amoebae that causes Legionnaires' Disease in immunocompromised individuals via replication within macrophages…”
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Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17 by Arasaki, Kohei, Mikami, Yumi, Shames, Stephanie R., Inoue, Hiroki, Wakana, Yuichi, Tagaya, Mitsuo

“…During infection of macrophages, the pathogenic bacterium Legionella pneumophila secretes effector proteins that induce the conversion of the plasma…”
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Mechanisms of Effector-Mediated Immunity Revealed by the Accidental Human Pathogen Legionella pneumophila by Ngwaga, Tshegofatso, Chauhan, Deepika, Shames, Stephanie R

“…Many Gram-negative bacterial pathogens employ translocated virulence factors, termed effector proteins, to facilitate their parasitism of host cells and evade…”
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Bacterial effector interplay: a new way to view effector function by Shames, Stephanie R, Finlay, B. Brett

“…Bacterial pathogens are dependent on virulence factors to efficiently colonize and propagate within their hosts. Many Gram-negative bacterial pathogens rely on…”
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Affecting the Effectors: Regulation of Legionella pneumophila Effector Function by Metaeffectors by Joseph, Ashley M, Shames, Stephanie R

“…Many bacterial pathogens utilize translocated virulence factors called effectors to successfully infect their host. Within the host cell, effector proteins…”
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Intrabacterial Regulation of a Cytotoxic Effector by Its Cognate Metaeffector Promotes Legionella pneumophila Virulence by Chauhan, Deepika, Joseph, Ashley M, Shames, Stephanie R

“…Legionella pneumophila is a natural pathogen of unicellular protozoa that can opportunistically infect macrophages and cause Legionnaires' Disease…”
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Attaching and Effacing Bacterial Effector NleC Suppresses Epithelial Inflammatory Responses by Inhibiting NF-κB and p38 Mitogen-Activated Protein Kinase Activation by Sham, Ho Pan, Shames, Stephanie R, Croxen, Matthew A, Ma, Caixia, Chan, Justin M, Khan, Mohammed A, Wickham, Mark E, Deng, Wanyin, Finlay, B Brett, Vallance, Bruce A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Eat or Be Eaten: Strategies Used by Legionella to Acquire Host-Derived Nutrients and Evade Lysosomal Degradation by Shames, Stephanie R

“…To replicate within host cells, bacterial pathogens must acquire host-derived nutrients while avoiding degradative antimicrobial pathways. Fundamental insights…”
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The Type III System-Secreted Effector EspZ Localizes to Host Mitochondria and Interacts with the Translocase of Inner Mitochondrial Membrane 17b by SHAMES, Stephanie R, CROXEN, Matthew A, WANYIN DENG, FINLAY, B. Brett

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300 by Shames, Stephanie R., Bhavsar, Amit P., Croxen, Matthew A., Law, Robyn J., Mak, Stefanie H. C., Deng, Wanyin, Li, Yuling, Bidshari, Roza, de Hoog, Carmen L., Foster, Leonard J., Finlay, B. Brett

“…Summary Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC respectively) are attaching and effacing bacterial pathogens that cause…”
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Breaking the stereotype: virulence factor-mediated protection of host cells in bacterial pathogenesis by Shames, Stephanie R, Finlay, B Brett

“…  Yersinia spp., Shigella flexneri, Helicobacter pylori, and diarrheagenic Escherichia coli are well known for their ability to kill host cells. Yersinia…”
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15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium by Buckner, Michelle M C, Antunes, L Caetano M, Gill, Navkiran, Russell, Shannon L, Shames, Stephanie R, Finlay, B Brett

“…15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is an anti-inflammatory downstream product of the cyclooxygenase enzymes. It has been implicated to play a…”
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Correction: Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions by Ngwaga, Tshegofatso, Chauhan, Deepika, Salberg, Abigail G., Shames, Stephanie R.

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Screening Targeted Legionella pneumophila Mutant Libraries In Vivo Using INSeq by Shames, Stephanie R

“…Legionella pneumophila is an intracellular bacterial pathogen that can cause a severe inflammatory pneumonia in humans called Legionnaires' disease, which…”
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Potentiation of Cytokine-Mediated Restriction of Legionella Intracellular Replication by a Dot/Icm-Translocated Effector by Ngwaga, Tshegofatso, Hydock, Alex J, Ganesan, Sandhya, Shames, Stephanie R

“…is ubiquitous in freshwater environments, where it replicates within unicellular protozoa. However, is also an accidental human pathogen that can cause…”
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Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries by Shames, Stephanie R., Liu, Luying, Havey, James C., Schofield, Whitman B., Goodman, Andrew L., Roy, Craig R.

“…Legionella pneumophila is the causative agent of a severe pneumonia called Legionnaires’ disease. A single strain of L. pneumophila encodes a repertoire of…”
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The Legionella pneumophila Metaeffector Lpg2505 (MesI) Regulates SidI-Mediated Translation Inhibition and Novel Glycosyl Hydrolase Activity by Joseph, Ashley M, Pohl, Adrienne E, Ball, Theodore J, Abram, Troy G, Johnson, David K, Geisbrecht, Brian V, Shames, Stephanie R

“…, the etiological agent of Legionnaires' disease, employs an arsenal of hundreds of Dot/Icm-translocated effector proteins to facilitate replication within…”
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High-polyphenol extracts from Sorghum bicolor attenuate replication of Legionella pneumophila within RAW 264.7 macrophages by Gilchrist, Aubrey K, Smolensky, Dmitriy, Ngwaga, Tshegofatso, Chauhan, Deepika, Cox, Sarah, Perumal, Ramasamy, Noronha, Leela E, Shames, Stephanie R

“…ABSTRACT Polyphenols derived from a variety of plants have demonstrated antimicrobial activity against diverse microbial pathogens. Legionella pneumophila is…”
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Acyl Histidines: New N‐Acyl Amides from Legionella pneumophila by Tørring, Thomas, Shames, Stephanie R., Cho, Wooyoung, Roy, Craig R., Crawford, Jason M.

“…Legionella pneumophila, the causative agent of Legionnaires' disease, is a Gram‐negative gammaproteobacterial pathogen that infects and intracellularly…”
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