Search Results - "Shamburek, R D"

In Vivo Evidence for Both Lipolytic and Nonlipolytic Function of Hepatic Lipase in the Metabolism of HDL by Dugi, K A, Amar, M J. A, Haudenschild, C C, Shamburek, R D, Bensadoun, A, Hoyt, R F, Fruchart-Najib, J, Madj, Z, Brewer, H B, Santamarina-Fojo, S

“…ABSTRACTTo investigate the in vivo role that hepatic lipase (HL) plays in HDL metabolism independently of its lipolytic function, recombinant adenovirus (rAdV)…”
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The buried bumper syndrome: a new technique for safe, endoscopic PEG removal by Boyd, John W., DeLegge, Mark H., Shamburek, Robert D., Kirby, Donald F.

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Disappearance of two major phosphatidylcholines from plasma is predominantly via LCAT and hepatic lipase by Shamburek, R D, Zech, L A, Cooper, P S, Vandenbroek, J M, Schwartz, C C

“…Metabolism of 1-stearoyl-2-arachidonyl-phosphatidyl-choline (SAPC), a major phosphatidylcholine (PC) species in rat plasma, was compared with…”
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ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice by Vaisman, B L, Lambert, G, Amar, M, Joyce, C, Ito, T, Shamburek, R D, Cain, W J, Fruchart-Najib, J, Neufeld, E D, Remaley, A T, Brewer, Jr, H B, Santamarina-Fojo, S

“…The discovery of the ABCA1 lipid transporter has generated interest in modulating human plasma HDL levels and atherogenic risk by enhancing ABCA1 gene…”
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Selective composition of biliary phosphatidylcholines is affected by secretion rate but not by bile acid hydrophobicity by Shamburek, R.D, Schwartz, C.C

“…Little is known about the mechanisms of: 1) biliary phosphatidylcholine PC) secretion by the hepatocyte, 2) selectivity for biliary 1-palmitoyl-2-linoleoyl-PC…”
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Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation by Shamburek, R D, Pentchev, P G, Zech, L A, Blanchette-Mackie, J, Carstea, E D, VandenBroek, J M, Cooper, P S, Neufeld, E B, Phair, R D, Brewer, Jr, H B, Brady, R O, Schwartz, C C

“…Niemann-Pick C disease (NP-C) is a rare inborn error of metabolism with hepatic involvement and neurological sequelae that usually manifest in childhood…”
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Control of acid secretion by Schubert, M L, Shamburek, R D

“…Receptors for the main neural (acetylcholine), hormonal (gastrin) and paracrine (histamine) secretory stimulants and the signal transduction pathways to which…”
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Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice by Foger, B, Chase, M, Amar, M.J, Vaisman, B.L, Shamburek, R.D, Paigen, B, Fruchart-Najib, J, Paiz, J.A, Koch, C.A, Hoyt, R.F

“…Expression of human lecithin cholesterol acyltransferase (LCAT) in mice (LCAT-Tg) leads to increased high density lipoprotein (HDL) cholesterol levels but…”
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Disorders of the Digestive System in the Elderly by Shamburek, Robert D, Farrar, John T

“…CHANGES in the anatomy and physiology of the epithelium of the digestive organs because of aging are slight. 1 The functional capacity of both the secretory…”
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Hepatic ABCG5 and ABCG8 Overexpression Increases Hepatobiliary Sterol Transport but Does Not Alter Aortic Atherosclerosis in Transgenic Mice by Wu, Justina E., Basso, Federica, Shamburek, Robert D., Amar, Marcelo J.A., Vaisman, Boris, Szakacs, Gergely, Joyce, Charles, Tansey, Terese, Freeman, Lita, Paigen, Beverly J., Thomas, Fairwell, Brewer, H. Bryan, Santamarina-Fojo, Silvia

“…The individual roles of hepatic versus intestinal ABCG5 and ABCG8 in sterol transport have not yet been investigated. To determine the specific contribution of…”
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Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL by Foger, B, Santamarina-Fojo, S, Shamburek, R.D, Parrot, C.L, Talley, G.D, Brewer, H.B. Jr

“…In vitro studies have shown that plasma phospholipid transfer protein (PLTP) converts isolated human high density lipoprotein-3 (HDL3) into larger HDL…”
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Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: Receptor expression modulates high-density lipoproteins by Brown, David R., Brousseau, Margaret E., Shamburek, Robert D., Talley, Glenda D., Meyn, Susan, Demosky, Stephen J., Santamarina-Fojo, Silvia, Brewer, H.Bryan, Hoeg, Jeffrey M.

“…Plasma concentrations of low-density lipoproteins (LDLs) and high-density lipoproteins (HDLs) are inversely related in several dyslipoproteinemias. To…”
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Erdheim-Chester disease: a rare multisystem histiocytic disorder associated with interstitial lung disease by Shamburek, R D, Brewer, Jr, H B, Gochuico, B R

“…Erdheim-Chester disease (ECD) is a rare multisystem histiocytosis syndrome of unknown cause that usually affects adults. Histiocytic infiltration of multiple…”
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Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo by Lambert, G, Amar, M J, Martin, P, Fruchart-Najib, J, Föger, B, Shamburek, R D, Brewer, Jr, H B, Santamarina-Fojo, S

“…Recent in vitro studies have provided evidence that hepatic lipase (HL) facilitates the selective uptake of HDL cholesteryl esters (CE), but the in vivo…”
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Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice by Amar, M J, Dugi, K A, Haudenschild, C C, Shamburek, R D, Foger, B, Chase, M, Bensadoun, A, Hoyt, Jr, R F, Brewer, Jr, H B, Santamarina-Fojo, S

“…We have investigated the role of hepatic lipase (HL) in remnant lipoprotein metabolism independent of lipolysis by using recombinant adenovirus to express…”
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Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction by Shiffman, M L, Shamburek, R D, Schwartz, C C, Sugerman, H J, Kellum, J M, Moore, E W

“…Arachidonic acid (AA) and hydrophobic bile salts (BS) stimulate gallbladder mucin (GBM) secretion, which is thought to be an essential step in gallstone…”
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Omeprazole and neutrophil function by Shamburek, R D, Ruddy, S, Schubert, M L

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MR virtual angioscopy of Thoracic aortic atherosclerosis in homozygous familial hypercholesterolemia by SUMMERS, Ronald M, CHOYKE, Peter L, PATRONAS, Nicholas J, TUCKER, Eben, WISE, Betty, BUSSE, Mary K, BREWER, H. Bryan, SHAMBUREK, Robert D

“…The thoracic aorta is an important site of atherosclerotic disease in patients with homozygous familial hypercholesterolemia (HFH). Thoracic aortic…”
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Cell-free, high-density lipoprotein-specific phospholipid efflux assay predicts incident cardiovascular disease by Sato, Masaki, Neufeld, Edward B, Playford, Martin P, Lei, Yu, Sorokin, Alexander V, Aponte, Angel M, Freeman, Lita A, Gordon, Scott M, Dey, Amit K, Jeiran, Kianoush, Hamasaki, Masato, Sampson, Maureen L, Shamburek, Robert D, Tang, Jingrong, Chen, Marcus Y, Kotani, Kazuhiko, Anderson, Josephine Lc, Dullaart, Robin Pf, Mehta, Nehal N, Tietge, Uwe Jf, Remaley, Alan T

“…BACKGROUNDCellular cholesterol efflux capacity (CEC) is a better predictor of cardiovascular disease (CVD) events than HDL-cholesterol (HDL-C) but is not…”
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Meta‐Analysis of Natural Therapies for Hyperlipidemia: Plant Sterols and Stanols versus Policosanol by Chen, Judy T., Wesley, Robert, Shamburek, Robert D., Pucino, Frank, Csako, Gyorgy

“…Study Objective. To compare the efficacy and safety of plant sterols and stanols as well as policosanol in the treatment of coronary heart disease, as measured…”
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