The effect of thiophosphamide on the proliferative activity of human tumor cells cultured in vivo in diffusion chambers

The effect of thiophosphamide on the proliferative activity of 16 different human tumors was studied. The most universal primary cellular mechanism of the drug action is to block cells in the premitotic phase of the cell cycle. The coefficient of thiophosphamide activity in diffusion chambers was sh...

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Bibliographic Details
Published in:	Archiv fur Geschwulstforschung Vol. 54; no. 2; p. 105
Main Authors:	Korman, D B, Krutova, T V, Shamajev, V I
Format:	Journal Article
Language:	English
Published:	Germany 1984
Subjects:	Animals Breast Neoplasms - pathology Cell Division - drug effects Colonic Neoplasms - pathology Female Humans Lung Neoplasms - pathology Mice Mice, Inbred CBA Micropore Filters Mitotic Index - drug effects Neoplasms - pathology Stomach Neoplasms - pathology Thiotepa - pharmacology
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Summary:	The effect of thiophosphamide on the proliferative activity of 16 different human tumors was studied. The most universal primary cellular mechanism of the drug action is to block cells in the premitotic phase of the cell cycle. The coefficient of thiophosphamide activity in diffusion chambers was shown to correlate with the known clinical efficacy of the drug in various tumor types.
ISSN:	0003-911X