Search Results - "Sham, P C"

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits by PURCELL, S, CHERNY, S. S, SHAM, P. C

“…A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits. The package is made available…”
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Genomic diversity of Epstein-Barr virus genomes isolated from primary nasopharyngeal carcinoma biopsy samples by Kwok, H, Wu, C W, Palser, A L, Kellam, P, Sham, P C, Kwong, D L W, Chiang, A K S

“…Undifferentiated nasopharyngeal carcinoma (NPC) has a 100% association with Epstein-Barr virus (EBV). However, only three EBV genomes isolated from NPC…”
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Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study by MacCabe, J H, Lambe, M P, Cnattingius, S, Torrång, A, Björk, C, Sham, P C, David, A S, Murray, R M, Hultman, C M

“…There is abundant evidence that schizophrenia is associated with cognitive deficits in childhood. However, previous studies investigating school performance…”
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White-matter microstructure in previously drug-naive patients with schizophrenia after 6 weeks of treatment by Wang, Q, Cheung, C, Deng, W, Li, M, Huang, C, Ma, X, Wang, Y, Jiang, L, Sham, P C, Collier, D A, Gong, Q, Chua, S E, McAlonan, G M, Li, T

“…It is not clear whether the progressive changes in brain microstructural deficits documented in previous longitudinal magnetic resonance imaging (MRI) studies…”
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Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain by Basil, P, Li, Q, Dempster, E L, Mill, J, Sham, P-C, Wong, C C Y, McAlonan, G M

“…Epigenetic processes such as DNA methylation have been implicated in the pathophysiology of neurodevelopmental disorders including schizophrenia and autism…”
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Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia by Cheung, V, Chiu, C P Y, Law, C W, Cheung, C, Hui, C L M, Chan, K K S, Sham, P C, Deng, M Y, Tai, K S, Khong, P-L, McAlonan, G M, Chua, S-E, Chen, E

“…We investigated cerebral structural connectivity and its relationship to symptoms in never-medicated individuals with first-onset schizophrenia using diffusion…”
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Striatal dopamine synthesis capacity and its association with negative symptoms upon resolution of positive symptoms in first-episode schizophrenia and delusional disorder by Wong, Stephanie M. Y., Suen, Y. N., Wong, Charlotte W. C., Chan, Sherry K. W., Hui, Christy L. M., Chang, W. C., Lee, Edwin H. M., Cheng, Calvin P. W., Ho, Garrett C. L., Lo, Gladys Goh, Leung, Eric Y. L., Yeung, Paul K. M. Au, Chen, Sirong, Honer, William G., Mak, Henry K. F., Sham, P. C., McKenna, Peter J., Pomarol-Clotet, Edith, Veronese, Mattia, Howes, Oliver D., Chen, Eric Y. H.

“…Rationale How striatal dopamine synthesis capacity (DSC) contributes to the pathogenesis of negative symptoms in first-episode schizophrenia (SZ) and…”
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HLA-B38:02:01 predicts carbimazole/methimazole-induced agranulocytosis by Cheung, C-L, Sing, C-W, Tang, CSM, Cheng, VKF, Pirmohamed, M, Choi, C-H, Hung, C-S, Lau, EY-F, Lee, KF, Mak, MW-H, Leung, JYY, Wong, T-W, Ho, AYY, Chan, K-W, Hung, VHF, Tam, V, Siu, S-C, Pang, H-K, Wat, WZ-M, Lee, HH-Y, Chung, C-T, Hue, RS-M, Sham, P-C, Cheung, BMY, Wong, ICK, Tan, KCB, Kung, AWC

“…Thioamides antithyroid‐drugs (ATDs) are important in hyperthyroid disease management. Identification of the susceptibility locus of ATD‐induced agranulocytosis…”
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Abnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia by Wang, Q, Deng, W, Huang, C, Li, M, Ma, X, Wang, Y, Jiang, L, Lui, S, Huang, X, Chua, S E, Cheung, C, McAlonan, G M, Sham, P C, Murray, R M, Collier, D A, Gong, Q, Li, T

“…Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and…”
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Volume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment by Li, M, Chen, Z, Deng, W, He, Z, Wang, Q, Jiang, L, Ma, X, Wang, Y, Chua, S E, Cheung, C, McAlonan, G M, Sham, P C, Collier, D A, Gong, Q, Li, T

“…Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of…”
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Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family by Li, M, Pang, SYY, Song, Y, Kung, MHW, Ho, S-L, Sham, P-C

“…Li M, Pang SYY, Song Y, Kung MHW, Ho S‐L, Sham P‐C. Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar…”
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A Note on the Calculation of Empirical P Values from Monte Carlo Procedures by North, B.V., Curtis, D., Sham, P.C.

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Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES) by Leung, Gordon K C, Mak, Christopher C Y, Fung, Jasmine L F, Wong, Wilfred H S, Tsang, Mandy H Y, Yu, Mullin H C, Pei, Steven L C, Yeung, K S, Mok, Gary T K, Lee, C P, Hui, Amelia P W, Tang, Mary H Y, Chan, Kelvin Y K, Liu, Anthony P Y, Yang, Wanling, Sham, P C, Kan, Anita S Y, Chung, Brian H Y

“…Whole-exome sequencing (WES) has become an invaluable tool for genetic diagnosis in paediatrics. However, it has not been widely adopted in the prenatal…”
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Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia: morphometrical and covariation study by Chen, Z, Deng, W, Gong, Q, Huang, C, Jiang, L, Li, M, He, Z, Wang, Q, Ma, X, Wang, Y, Chua, S E, McAlonan, G M, Sham, P C, Collier, D A, McGuire, P, Li, T

“…Alterations in gray matter (GM) are commonly observed in schizophrenia. Accumulating studies suggest that the brain changes associated with schizophrenia are…”
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Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis by Chen, C K, Lin, S K, Sham, P C, Ball, D, Loh, E W, Hsiao, C C, Chiang, Y L, Ree, S C, Lee, C H, Murray, R M

“…The long-term use of methamphetamine (MAMP) can result in psychosis but it is not clear why some individuals develop psychotic symptoms, while others use MAMP…”
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Combined Linkage and Association Sib-Pair Analysis for Quantitative Traits by Fulker, D.W., Cherny, S.S., Sham, P.C., Hewitt, J.K.

“…An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of…”
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Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects by Cheung, C.-L., Sham, P.-C., Xiao, S.-M., Bow, C. H., Kung, A. W.-C.

“…Summary Gene-based association approach could be regarded as a complementary analysis to the single SNP association analysis. We meta-analyzed the findings…”
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Monte Carlo tests for associations between disease and alleles at highly polymorphic loci by Sham, P C, Curtis, D

“…In an association analysis comparing cases and controls with respect to allele frequencies at a highly polymorphic locus, a potential problem is that the…”
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Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction by Cheng, G L F, Zeng, H, Leung, M-K, Zhang, H-J, Lau, B W M, Liu, Y-P, Liu, G-X, Sham, P C, Chan, C C H, So, K-F, Lee, T M C

“…Heroin abuse and natural aging exert common influences on immunological cell functioning. This observation led to a recent and untested idea that aging may be…”
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An extended transmission/disequilibrium test (TDT) for multi-allele marker loci by Sham, P C, Curtis, D

“…The transmission/disequilibrium test (TDT) was recently introduced by Spielman et al. (1993) as a test for linkage and linkage disequilibrium. The test is…”
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