Search Results - "Sham, James S K"

Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle by Yang, Xiao-Ru, Lin, Mo-Jun, McIntosh, Lionel S, Sham, James S K

“…Transient receptor potential melastatin- (TRPM) and vanilloid-related (TRPV) channels are nonselective cation channels pertinent to diverse physiological…”
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Chronic hypoxia‐induced upregulation of Ca2+‐activated Cl− channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity by Sun, Hui, Xia, Yang, Paudel, Omkar, Yang, Xiao‐Ru, Sham, James S. K.

“…Key points •  A prolonged reduced oxygen level in the lungs, as occurs in patients of many chronic lung diseases and in residents living at high altitude,…”
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Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox) by Liu, John Q, Zelko, Igor N, Erbynn, Efua M, Sham, James S K, Folz, Rodney J

“…Chronic exposure to low-O2 tension induces pulmonary arterial hypertension (PAH), which is characterized by vascular remodeling and enhanced vasoreactivity…”
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Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension by Yang, Xiao-Ru, Lin, Amanda H Y, Hughes, Jennifer M, Flavahan, Nicholas A, Cao, Yuan-Ning, Liedtke, Wolfgang, Sham, James S K

“…Chronic hypoxia causes pulmonary hypertension with vascular remodeling, increase in vascular tone, and altered reactivity to agonists. These changes involve…”
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Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes by Zhang, Li, Au-Yeung, Chi-Lam, Huang, Chunxian, Yeung, Tsz-Lun, Ferri-Borgogno, Sammy, Lawson, Barrett C, Kwan, Suet-Ying, Yin, Zheng, Wong, Stephen T, Thomas, Vienna, Lu, Karen H, Yip, Kay-Pong, Sham, James S. K, Mok, Samuel C

“…Background Uterine serous cancer (USC) is the most common non-endometrioid subtype of uterine cancer, and is also the most aggressive. Most patients will die…”
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Enhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats by Liu, Xiao-Ru, Zhang, Ming-Fang, Yang, Na, Liu, Qing, Wang, Rui-Xing, Cao, Yuan-Ning, Yang, Xiao-Ru, Sham, James S K, Lin, Mo-Jun

“…Pulmonary hypertension (PH) is associated with profound vascular remodeling and alterations in Ca(2+) homeostasis in pulmonary arterial smooth muscle cells…”
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Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells by Lin, Mo-Jun, Yang, Xiao-Ru, Cao, Yuan-Ning, Sham, James S K

“…Reactive oxygen species (ROS) generated from NADPH oxidases and mitochondria have been implicated as key messengers for pulmonary vasoconstriction and vascular…”
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Carotid body denervation improves hyperglycemia in obese mice by Shin, Mi-Kyung, Tang, Wan-Yee, Amorim, Mateus R, Sham, James S-K, Polotsky, Vsevolod Y

“…The carotid bodies (CBs) have been implicated in glucose abnormalities in obesity via elevation of activity of the sympathetic nervous system. Obesity-induced…”
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Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction by Liggett, Stephen B, Deshpande, Deepak A, Wang, Wayne C H, McIlmoyle, Elizabeth L, Robinett, Kathryn S, Schillinger, Rachel M, An, Steven S, Sham, James S K

“…G protein-coupled receptor (GPCR)-mediated increases in intracellular calcium generally lead to constriction of airway smooth muscle. Deshpande et al . find…”
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Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks by Balasubramanian, Lavanya, Ahmed, Abu, Lo, Chun-Min, Sham, James S K, Yip, Kay-Pong

“…Integrins are transmembrane heterodimeric proteins that link extracellular matrix (ECM) to cytoskeleton and have been shown to function as mechanotransducers…”
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Remanent cell traction force in renal vascular smooth muscle cells induced by integrin-mediated mechanotransduction by Balasubramanian, Lavanya, Lo, Chun-Min, Sham, James S K, Yip, Kay-Pong

“…It was previously demonstrated in isolated renal vascular smooth muscle cells (VSMCs) that integrin-mediated mechanotransduction triggers intracellular Ca(2+)…”
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Leptin Induces Epigenetic Regulation of Transient Receptor Potential Melastatin 7 in Rat Adrenal Pheochromocytoma Cells by Yeung, Bonnie Ho-Yee, Griffiths, Kelly, Berger, Liron, Paudel, Omkar, Shin, Mi-Kyung, Rui, Liangyou, Sham, James S K, Polotsky, Vsevolod Y, Tang, Wan-Yee

“…Obesity elevates the plasma level of leptin, which has been associated with hypertension. Our recent studies in mice demonstrated that leptin increases blood…”
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Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response by Caballero‐Eraso, Candela, Shin, Mi‐Kyung, Pho, Huy, Kim, Lenise J, Pichard, Luis E., Wu, Zhi‐Juan, Gu, Chenjuan, Berger, Slava, Pham, Luu, Yeung, Ho‐Yee (Bonnie), Shirahata, Machiko, Schwartz, Alan R., Tang, Wan‐Yee (Winnie), Sham, James S. K., Polotsky, Vsevolod Y.

“…Key points Leptin is a potent respiratory stimulant. A long functional isoform of leptin receptor, LepRb, was detected in the carotid body (CB), a key…”
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Epac induces ryanodine receptor-dependent intracellular and inter-organellar calcium mobilization in mpkCCD cells by Yip, Kay-Pong, Ribeiro-Silva, Luisa, Cha, Byeong, Rieg, Timo, Sham, James S. K.

“…Arginine vasopressin (AVP) induces an increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ) with an oscillatory pattern in isolated perfused kidney inner…”
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Classical Transient Receptor Potential 1 and 6 Contribute to Hypoxic Pulmonary Hypertension Through Differential Regulation of Pulmonary Vascular Functions by Xia, Yang, Yang, Xiao-Ru, Fu, Zhenzhen, Paudel, Omkar, Abramowitz, Joel, Birnbaumer, Lutz, Sham, James S.K

“…Hypoxic pulmonary hypertension is characterized by increased vascular tone, altered vasoreactivity, and vascular remodeling, which are associated with…”
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Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole by Yip, Kay-Pong, Balasubramanian, Lavanya, Kan, Chen, Wang, Lei, Liu, Ruisheng, Ribeiro-Silva, Luisa, Sham, James S K

“…Myogenic contraction of renal arterioles is an important regulatory mechanism for renal blood flow autoregulation. We have previously demonstrated that…”
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Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration by Song, Jia-Lin, Zheng, Si-Yi, He, Rui-Lan, Gui, Long-Xin, Lin, Mo-Jun, Sham, James S.K.

“…5-Hydroxytryptamine (5-HT)-dependent signaling mediated through its transporters and receptors plays important roles in chronic hypoxic pulmonary hypertension…”
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Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension by Paudel, Omkar, Jin, Rui, Jin, Zhou, Xia, Lexin, Xia, Yang, Sham, James S. K.

“…Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to…”
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Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct by Yip, Kay-Pong, Sham, James S K

“…Arginine vasopressin (AVP) causes increase in intracellular Ca(2+) concentration with an oscillatory pattern. Ca(2+) mobilization is required for…”
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Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells by Yang, Xiao-Ru, Lin, Mo-Jun, Sham, James S K

“…The transient receptor potential (TRP) gene superfamily, which consists of 7 subfamilies with at least 28 mammalian homologues, is known to encode a wide…”
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