Search Results - "Sham, H P"

Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice by Lee, A. S, Gibson, D. L, Zhang, Y, Sham, H. P, Vallance, B. A, Dutz, J. P

“…Aims/hypothesis Increased exposure to enteric microbes as a result of intestinal barrier disruption is thought to contribute to the development of several…”
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The goblet cell-derived mediator RELM-β drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis by Morampudi, V, Dalwadi, U, Bhinder, G, Sham, H P, Gill, S K, Chan, J, Bergstrom, K S B, Huang, T, Ma, C, Jacobson, K, Gibson, D L, Vallance, B A

“…Intestinal goblet cells are potentially key players in controlling susceptibility to ulcerative colitis (UC). Although impaired mucin (Muc2) production by…”
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Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation by Abdulnour, R E, Sham, H P, Douda, D N, Colas, R A, Dalli, J, Bai, Y, Ai, X, Serhan, C N, Levy, B D

“…Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Host responses to contain infection and mitigate pathogen-mediated lung…”
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A Nonsynonymous Polymorphism of IRAK4 Associated with Increased Prevalence of Gram-Positive Infection and Decreased Response to Toll-Like Receptor Ligands by Sutherland, Ainsley M., Walley, Keith R., Nakada, Taka-aki, Sham, Andy H.P., Wurfel, Mark M., Russell, James A.

“…Mutations in IRAK4 have been associated with recurrent Gram-positive infections in children. Given the central role of IRAK4 in innate immunity signaling, we…”
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Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation by Abdulnour, R.E., Sham, H.P., Douda, D.N., Colas, R.A., Dalli, J., Bai, Y., Ai, X., Serhan, C.N., Levy, B.D.

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A48 LYOPHILIZED FECAL MICROBIOTA TRANSPLANT (FMT) DELAYS THE ONSET OF SPONTANEOUS COLITIS IN MUC2-/- MICE by Chan, J J, Chan, C, Sham, H P, Vallance, B

“…Abstract Background Fecal microbiota transplant (FMT) is the transfer of fecal microbes from a healthy donor to a recipient to normalize gut microbiota. FMT…”
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Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens by Knodler, Leigh A., Crowley, Shauna M., Sham, Ho Pan, Yang, Hyungjun, Wrande, Marie, Ma, Caixia, Ernst, Robert K., Steele-Mortimer, Olivia, Celli, Jean, Vallance, Bruce A.

“…Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal…”
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The goblet cell-derived mediator RELM-[beta] drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis by Morampudi, V, Dalwadi, U, Bhinder, G, Sham, H P, Gill, S K, Chan, J, Bergstrom, K S B, Huang, T, Ma, C, Jacobson, K, Gibson, D L, Vallance, B A

“…Intestinal goblet cells are potentially key players in controlling susceptibility to ulcerative colitis (UC). Although impaired mucin (Muc2) production by…”
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An overnight high-dose dexamethasone suppression test for rapid differential diagnosis of Cushing's syndrome by Tyrrell, J B, Findling, J W, Aron, D C, Fitzgerald, P A, Forsham, P H

“…We have developed a high-dose dexamethasone suppression test that can be administered overnight with a single 8-mg dose and used the new procedure in the…”
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Tissue effects of glucocorticoids by Baxter, J D, Forsham, P H

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Cushing's disease. Selective trans-sphenoidal resection of pituitary microadenomas by Tyrrell, J B, Brooks, R M, Fitzgerald, P A, Cofoid, P B, Forsham, P H, Wilson, C B

“…We undertook trans-sphenoidal microsurgical pituitary exploration in 20 consecutive patients with Cushing's disease, eight of whom had normal sellar…”
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Lack of Glucagon Response to Hypoglycemia in Diabetes: Evidence for an Intrinsic Pancreatic Alpha Cell Defect by Gerich, John E., Langlois, Maurice, Noacco, Claudio, Karam, John H., Forsham, Peter H.

“…Despite excessive glucagon responses to infusion of arginine, plasma glucagon did not rise in six juvenile-type diabetics during severe insulin-induced…”
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Cushing's disease: transient secondary adrenal insufficiency after selective removal of pituitary microadenomas; evidence for a pituitary origin by Fitzgerald, P A, Aron, D C, Findling, J W, Brooks, R M, Wilson, C B, Forsham, P H, Tyrrell, J B

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Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon by Gerich, J E, Lorenzi, M, Bier, D M, Schneider, V, Tsalikian, E, Karam, J H, Forsham, P H

“…To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we studied the effect of suppression of glucagon secretion by…”
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Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin by Gerich, J E, Lorenzi, M, Bier, D M, Tsalikian, E, Schneider, V, Karam, J H, Forsham, P H

“…To study the individual effects of glucagon and growth hormone on human carbohydrate and lipid metabolism, endogenous secretion of both hormones was…”
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Cushing's syndrome: problems in diagnosis by Aron, D C, Tyrrell, J B, Fitzgerald, P A, Findling, J W, Forsham, P H

“…Cushing's syndrome, an unusual group of disorders characterized by hypercortisolism, must be considered in the differential diagnosis of such common clinical…”
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Milestones in the 60-year history of insulin (1922-1982) by Forsham, P H

“…Important events in the discovery of insulin and in its 60-yr history are presented…”
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Pituitary ACTH dependency of nodular adrenal hyperplasia in Cushing's syndrome. Report of two cases and review of the literature by Aron, D C, Findling, J W, Fitzgerald, P A, Brooks, R M, Fisher, F E, Forsham, P H, Tyrrell, J B

“…Cushing's syndrome due to nodular adrenal hyperplasia comprises a clinically and biochemically heterogeneous group of disorders whose pathogenesis is unclear…”
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Silent pituitary apoplexy: subclinical infarction of an adrenocorticotropin-producing pituitary adenoma by Findling, J W, Tyrrell, J B, Aron, D C, Fitzgerald, P A, Wilson, C B, Forsham, P H

“…A young woman developed intermittent headaches and progressive hyperpigmentation after bilateral adrenalectomy for Cushing's disease. Results of sellar…”
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Effects of somatostatin on plasma glucose and glucagon levels in human diabetes mellitus. Pathophysiologic and therapeutic implications by Gerich, J E, Lorenzi, M, Schneider, V, Karam, J H, Rivier, J, Guillemin, R, Forsham, P H

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