Search Results - "Shaller, Calvin"

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors by RUDNICK, Stephen I, JIANLONG LOU, SHALLER, Calvin C, YONG TANG, KLEIN-SZANTO, Andres J. P, WEINER, Louis M, MARKS, James D, ADAMS, Gregory P

“…Antibody drugs are widely used in cancer therapy, but conditions to maximize tumor penetration and efficacy have yet to be fully elucidated. In this study, we…”
Get full text

Evaluation of the Anti-HER2 C6.5 Diabody as a PET Radiotracer to Monitor HER2 status and Predict Response to Trastuzumab Treatment by REDDY, Smitha, SHALLER, Calvin C, DOSS, Mohan, SHCHAVELEVA, Irina, MARKS, James D, YU, Jian Q, ROBINSON, Matthew K

“…The rapid tumor targeting and pharmacokinetic properties of engineered antibodies make them potentially suitable for use in imaging strategies to predict and…”
Get full text

Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma by Chen, Peirong, Nogusa, Shoko, Thapa, Roshan J, Shaller, Calvin, Simmons, Heidi, Peri, Suraj, Adams, Gregory P, Balachandran, Siddharth

“…Metastatic renal cell carcinoma (RCC) is an incurable disease in clear need of new therapeutic interventions. In early-phase clinical trials, the cytokine…”
Get full text

Effective Treatment of Established Human Breast Tumor Xenografts in Immunodeficient Mice with a Single Dose of the α-Emitting Radioisotope Astatine-211 Conjugated to Anti-HER2/neu Diabodies by ROBINSON, Matthew K, SHALLER, Calvin, GARMESTANI, Kayhan, PLASCJAK, Paul S, HODGE, Kathryn M, YUAN, Qing-An, MARKS, James D, WALDMANN, Thomas A, BRECHBIE, Martin W, ADAMS, Gregory P

“…Purpose: Successful radioimmunotherapy strategies depend on selecting radioisotopes with physical properties complementary to the biological properties of the…”
Get full text

A single treatment of yttrium-90-labeled CHX-A-c6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice by ADAMS, Gregory P, SHALLER, Calvin C, DADACHOVA, Ekaterina, SIMMONS, Heidi H, HORAK, Eva M, TESFAYE, Abohawariat, KLEIN-SZANTO, Andres J. P, MARKS, James D, BRECHBIEL, Martin W, WEINER, Louis M

“…Antitumor diabody molecules are noncovalent single-chain Fv dimers that recapitulate the divalent binding properties of native IgG antibodies. Diabodies are…”
Get full text

Impact of expression system on the function of the C6.5 diabody PET radiotracer by Miller, Joshua, Doss, Mohan, McQuillen, Ryan, Shaller, Calvin C., Tolner, Berend, Yu, Jian Q., Chester, Kerry, Robinson, Matthew K.

“…The ability of engineered antibodies to rapidly and selectively target tumors that express their target antigen makes them well suited for use as radioimaging…”
Get full text

Anti-CD70 Immunocytokines for Exploitation of Interferon-[gamma]-Induced RIP1-Dependent Necrosis in Renal Cell Carcinoma by Chen, Peirong, Nogusa, Shoko, Thapa, Roshan J, Shaller, Calvin, Simmons, Heidi, Peri, Suraj, Adams, Gregory P, Balachandran, Siddharth

“…Metastatic renal cell carcinoma (RCC) is an incurable disease in clear need of new therapeutic interventions. In early-phase clinical trials, the cytokine…”
Get full text

Quantitation of Resonances in Biological31P NMR Spectra via Principal Component Analysis: Potential and Limitations by Kuesel, Annette C., Stoyanova, Radka, Aiken, Nanci R., Li, Chun-Wei, Szwergold, Benjamin S., Shaller, Calvin, Brown, Truman R.

Get full text

Quantitation of small-animal (124)I activity distributions using a clinical PET/CT scanner by González Trotter, Dinko E, Manjeshwar, Ravindra M, Doss, Mohan, Shaller, Calvin, Robinson, Matthew K, Tandon, Reeti, Adams, Gregory P, Adler, Lee P

“…Time-dependent PET imaging can be an important tool in the assessment of radiotracer performance in murine models. We have performed a quantitative analysis of…”
Get full text

Anti-CD70 Immunocytokines for Exploitation of Interferon- gamma -Induced RIP1-Dependent Necrosis in Renal Cell Carcinoma. e61446 by Chen, Peirong, Nogusa, Shoko, Thapa, Roshan J, Shaller, Calvin, Simmons, Heidi, Peri, Suraj, Adams, Gregory P, Balachandran, Siddharth

“…Metastatic renal cell carcinoma (RCC) is an incurable disease in clear need of new therapeutic interventions. In early-phase clinical trials, the cytokine IFN-…”
Get full text

Quantitation of Small-Animal ^sup 124^I Activity Distributions Using a Clinical PET/CT Scanner by Gonzalez Trotter, Dinko E, Manjeshwar, Ravindra M, Doss, Mohan, Shaller, Calvin

“…Time-dependent PET imaging can be an important tool in the assessment of radiotracer performance in murine models. We have performed a quantitative analysis of…”
Get full text

Quantitation of Small-Animal 124I Activity Distributions Using a Clinical PET/CT Scanner by Gonzalez Trotter, Dinko E, Manjeshwar, Ravindra M, Doss, Mohan, Shaller, Calvin, Robinson, Matthew K, Tandon, Reeti, Adams, Gregory P, Adler, Lee P

Get full text

Phosphomonoester concentrations differ between chronic lymphocytic leukemia cells and normal human lymphocytes by Franks, Suzanne E, Smith, Mitchell R, Arias-Mendoza, Fernando, Shaller, Calvin, Padavic-Shaller, Kristen, Kappler, Francis, Zhang, Yun, Negendank, William G, Brown, Truman R

“…Levels of phospholipid-related metabolites of chronic lymphocytic leukemia lymphocytes (CLL) and normal human lymphocytes were quantified using phosphorus…”
Get full text

Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody by ROBINSON, Matthew K, DOSS, Mohan, SHALLER, Calvin, NARAYANAN, Deepa, MARKS, James D, ADLER, Lee P, GONZALEZ TROTTER, Dinko E, ADAMS, Gregory P

“…Positron emission tomography (PET) provides an effective means of both diagnosing/staging several types of cancer and evaluating efficacy of treatment. To…”
Get full text

Quantitation of Resonances in Biological 31P NMR Spectra via Principal Component Analysis: Potential and Limitations by Kuesel, Annette C., Stoyanova, Radka, Aiken, Nanci R., Li, Chun-Wei, Szwergold, Benjamin S., Shaller, Calvin, Brown, Truman R.

“…This paper examines the potential and limitations of peak area quantitation of biological NMR spectra using principal component analysis (PCA), including its…”
Get full text

Effects of valinomycin on lymphocytes independent of potassium permeability by Negendank, W, Shaller, C

“…10(-7) M valinomycin affects human lymphocytes in the following manner: (1) it is non-toxic; (2) it inhibits mitogenesis; (3) it causes a reduction in cell…”
Get more information

Characterization of a phosphonium analog of choline as a probe in 31P NMR studies of phospholipid metabolism by Szwergold, B S, Kappler, F, Moldes, M, Shaller, C, Brown, T R

“…Tumors and transformed cells have been shown by 31P NMR to contain elevated concentrations of two phosphomonoesters, phosphorylcholine and…”
Get more information

The effects of temperature and ouabain on steady-state Na and K exchanges in human lymphocytes by Negendank, W, Shaller, C

Get more information

Potassium-sodium distribution in human lymphocytes: description by the association-induction hypothesis by Negendank, W, Shaller, C

“…Human lymphocytes were equilibrated for 48 hours over a wide range of external potassium levels, and their contents of potassium, sodium, and water determined…”
Get more information

Multiple fractions of sodium exchange in human lymphocytes by Negendank, W, Shaller, C

“…Human lymphocytes contain a large, saturable fraction of K+ that exchanges slowly with K+ in the external medium, and a small non-saturable fraction that…”
Get more information