Search Results - "Shaldam, Moataz A."

Multi-spectroscopic, thermodynamic, and molecular docking/dynamic approaches for characterization of the binding interaction between calf thymus DNA and palbociclib by Magdy, Galal, Shaldam, Moataz A., Belal, Fathalla, Elmansi, Heba

“…Studying the binding interaction between biological macromolecules and small molecules has formed the core of different research aspects. The interaction of…”
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Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity by Tawfik, Haytham O., Shaldam, Moataz A., Nocentini, Alessio, Salem, Rofaida, Almahli, Hadia, Al-Rashood, Sara T., Supuran, Claudiu T., Eldehna, Wagdy M.

“…Carbonic anhydrases (CAs) are one of the promising targets for the development of anticancer agents. CA isoforms are implicated in various physiological…”
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Chronotherapeutic neuroprotective effect of verapamil against lipopolysaccharide-induced neuroinflammation in mice through modulation of calcium-dependent genes by Mosalam, Esraa M., Elberri, Aya Ibrahim, Sallam, Amany Said, Salem, Heba Rady, Metwally, Ebtehal M., Abdallah, Mahmoud S., Shaldam, Moataz A., Mansour, Hend E. Abo

“…Abstract Background Neuroinflammation is a major mechanism in neurodegenerative diseases such as Alzheimer’s disease (AD), which is a major healthcare problem…”
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Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors by Shaldam, Moataz A., Almahli, Hadia, Angeli, Andrea, Badi, Rehab Mustafa, Khaleel, Eman F., Zain-Alabdeen, Abdelrahman I., Elsayed, Zainab M., Elkaeed, Eslam B., Salem, Rofaida, Supuran, Claudiu T., Eldehna, Wagdy M., Tawfik, Haytham O.

“…In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors…”
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A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa by Saqr, Ahmed Al, Aldawsari, Mohammed F., Khafagy, El-Sayed, Shaldam, Moataz A., Hegazy, Wael A. H., Abbas, Hisham A.

“…Pseudomonas aeruginosa can cause a variety of healthcare-associated infections by its arsenal of virulence factors. Virulence factor production is largely…”
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Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin by Saad, Hebatallah M., Elekhnawy, Engy, Shaldam, Moataz A., Alqahtani, Moneerah J., Altwaijry, Najla, Attallah, Nashwah G.M., Hussein, Ismail A., Ibrahim, Hanaa A., Negm, Walaa A., Salem, Esraa A.

“…Numerous efforts to manage acute kidney injury (AKI) were unsuccessful because its pathophysiology is still poorly understood. Thus, our research hotspot was…”
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Anti-Biofilm and Antibacterial Activities of Cycas media R. Br Secondary Metabolites: In Silico, In Vitro, and In Vivo Approaches by Attallah, Nashwah G M, Al-Fakhrany, Omnia Momtaz, Elekhnawy, Engy, Hussein, Ismail A, Shaldam, Moataz A, Altwaijry, Najla, Alqahtani, Moneerah J, Negm, Walaa A

“…Enterococcus species possess many virulence factors that have an essential role in exacerbating the infections caused by them. The current study aimed to…”
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Bilosomes as Nanoplatform for Oral Delivery and Modulated In Vivo Antimicrobial Activity of Lycopene by Binsuwaidan, Reem, Sultan, Amal A, Negm, Walaa A, Attallah, Nashwah G. M, Alqahtani, Moneerah J, Hussein, Ismail A, Shaldam, Moataz A, El-Sherbeni, Suzy A, Elekhnawy, Engy

“…Owing to the disseminating resistance among pathogenic bacteria, especially Klebsiella pneumoniae, there is a high need for alternate compounds with…”
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Study of the binding interaction of salmon sperm DNA with nintedanib, a tyrosine kinase inhibitor using multi-spectroscopic, thermodynamic, and in silico approaches by Radwan, Aya Saad, Salim, Mohamed M., Elkhoudary, Mahmoud M., Hadad, Ghada M., Shaldam, Moataz A., Belal, Fathalla, Magdy, Galal

“…The study of the intermolecular binding interaction of small molecules with DNA can guide the rational drug design with greater efficacy and improved or more…”
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Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect by Attallah, Nashwah G M, Kabbash, Amal, Negm, Walaa A, Elekhnawy, Engy, Binsuwaidan, Reem, Al-Fakhrany, Omnia Momtaz, Shaldam, Moataz A, Moglad, Ehssan, Tarek, Marwa, Samir, Nehal, Fawzy, Heba M

“…Diseases and infections of the respiratory tract are common global causes of morbidity and mortality. Our study attempts to elucidate a novel remedy for…”
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Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon by Aldawsari, Mohammed, Khafagy, El-Sayed, Saqr, Ahmed, Alalaiwe, Ahmed, Abbas, Hisham, Shaldam, Moataz, Hegazy, Wael, Goda, Reham

“…The bacterial resistance development due to the incessant administration of antibiotics has led to difficulty in their treatment. Natural adjuvant compounds…”
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Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens by Khayyat, Ahdab N., Hegazy, Wael A. H., Shaldam, Moataz A., Mosbah, Rasha, Almalki, Ahmad J., Ibrahim, Tarek S., Khayat, Maan T., Khafagy, El-Sayed, Soliman, Wafaa E., Abbas, Hisham A.

“…Serratia marcescens is an opportunistic nosocomial pathogen and causes wound and burn infections. It shows high resistance to antibiotics and its pathogenicity…”
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Secnidazole Is a Promising Imidazole Mitigator of Serratia marcescens Virulence by Khayyat, Ahdab N., Abbas, Hisham A., Khayat, Maan T., Shaldam, Moataz A., Askoura, Momen, Asfour, Hani Z., Khafagy, El-Sayed, Abu Lila, Amr S., Allam, Ahmed N., Hegazy, Wael A. H.

“…Serratia marcescens is an opportunistic pathogen that causes diverse nosocomial infections. S. marcescens has developed considerable resistance to different…”
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Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa by Khayat, Maan T, Ibrahim, Tarek S, Khayyat, Ahdab N, Alharbi, Majed, Shaldam, Moataz A, Mohammad, Khadijah A, Khafagy, El-Sayed, El-Damasy, Dalia A, Hegazy, Wael A H, Abbas, Hisham A

“…The development of bacterial resistance is an insistent global health care issue, especially in light of the dwindled supply of new antimicrobial agents. This…”
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Ketoprofen, piroxicam and indomethacin‐suppressed quorum sensing and virulence factors in Acinetobacter baumannii by Elshaer, Soha Lotfy, Shaldam, Moataz A., Shaaban, Mona I.

“…Aim Quorum sensing (QS) inhibition is a promising strategy to suppress bacterial virulence and control infection caused by Gram‐negative and Gram‐positive…”
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In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes by Shaldam, Moataz A., Yahya, Galal, Mohamed, Nashwa H., Abdel-Daim, Mohamed M., Al Naggar, Yahya

“…After the early advent of the Coronavirus Disease 2019 (COVID-19) pandemic, myriads of FDA-approved drugs have been massively repurposed for COVID-19 treatment…”
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Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations by Al-Karmalawy, Ahmed A., Nafie, Mohamed S., Shaldam, Moataz A., Elmaaty, Ayman Abo, Antar, Samar A., El-Hamaky, Anwar A., Saleh, Mohamed A., Elkamhawy, Ahmed, Tawfik, Haytham O.

“…Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-nucleoside selective telomerase inhibitor; however, it experiences…”
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Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections by Seleem, Noura M., Abd El Latif, Hemat K., Shaldam, Moataz A., El-Ganiny, Amira

“…The emergence of multidrug-resistant (MDR) strains is a major health problem worldwide. There is an urgent need for novel strategies to combat bacterial…”
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Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments by Al-Karmalawy, Ahmed A., Rashed, Mahmoud, Sharaky, Marwa, Abulkhair, Hamada S., Hammouda, Mohamed M., Tawfik, Haytham O., Shaldam, Moataz A.

“…Although the great effectiveness of doxorubicin (Dox) in the treatment of many types of tumors, it showed limited effectiveness against the head and neck…”
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Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments by Al-Karmalawy, Ahmed A., Mousa, Mai H. A., Sharaky, Marwa, Mourad, Mai A. E., El-Dessouki, Ahmed M., Hamouda, Amir O., Alnajjar, Radwan, Ayed, Abdelmoneim A., Shaldam, Moataz A., Tawfik, Haytham O.

“…Herein, modifications to the previously reported BIBR1591 were conducted to obtain bioisosteric candidates with improved activities. The % inhibition of the…”
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