Search Results - "Shalaev, E. Y."

A procedure to optimize scale-up for the primary drying phase of lyophilization by Kramer, T, Kremer, D M, Pikal, M J, Petre, W J, Shalaev, E Y, Gatlin, L A

“…This article describes a procedure to facilitate scale-up for the primary drying phase of lyophilization using a combination of empirical testing and numerical…”
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Experimental Study and Modeling of Freeze-Drying in Syringe Configuration. Part II: Mass and Heat Transfer Parameters and Sublimation End-Points by Hottot, A., Andrieu, J., Hoang, V., Shalaev, E. Y., Gatlin, L. A., Ricketts, S.

“…This work concerns the experimental study in syringe configuration of the sublimation period for a model formulation under operating conditions commonly used…”
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How does residual water affect the solid-state degradation of drugs in the amorphous state? by Shalaev, E Y, Zografi, G

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Influence of sorbitol on protein crowding in solution and freeze-concentrated phases by Khodadadi, S, Clark, N J, McAuley, A, Cristiglio, V, Curtis, J E, Shalaev, E Y, Krueger, S

“…Small-angle neutron scattering was employed to study protein crowding under freezing conditions that mimic those used in pharmaceutical processing. The results…”
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Acid-catalyzed inversion of sucrose in the amorphous state at very low levels of residual water by SHALAEV, E. Y, QUN LU, SHALAEVA, M, ZOGRAFI, G

“…Factors affecting the solid-state acid-catalyzed inversion of amorphous sucrose to glucose and fructose in the presence of colyophilized citric acid, with less…”
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Thermophysical properties of pharmaceutically compatible buffers at sub-zero temperatures: Implications for freeze-drying by SHALAEV, Evgenyi Y, JOHNSON-ELTON, Tiffany D, LIUQUAN CHANG, PIKAL, Michael J

“…To evaluate crystallization behavior and collapse temperature (Tg') of buffers in the frozen state, in view of its importance in the development of lyophilized…”
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Phase diagram of 1,2-dioleoylphosphatidylethanolamine (DOPE):water system at subzero temperatures and at low water contents by Shalaev, Evgenyi Y., Steponkus, Peter L.

“…The phase behavior of partially hydrated 1,2-dioleoylphosphatidylethanolamine (DOPE) has been studied using differential scanning calorimetry and X-ray…”
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Phase behavior and glass transition of 1,2-dioleoylphosphatidylethanolamine (DOPE) dehydrated in the presence of sucrose by Shalaev, Evgenyi Y, Steponkus, Peter L

“…The effect of sucrose on the phase behavior of 1,2-dioleoylphosphatidylethanolamine (DOPE) as a function of hydration was studied using differential scanning…”
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Correction of the sample weight in hermetically sealed DSC pans by Shalaev, Evgenyi Y, Steponkus, Peter L

“…The weight of a DSC sample is routinely determined as the difference between the weight of the pan containing the sample and the empty pan. If the sample is…”
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Effects of processing on the solid-state methyl transfer of tetraglycine methyl ester by Shalaev, Evgenyi Yu, Shalaeva, Marina, Byrn, Stephen R., Zografi, George

“…The thermally induced solid-state methyl transfer of tetraglycine methyl ester (TGME) was followed by HPLC analysis for samples subjected to freeze-drying and…”
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Thermodynamic and dynamic factors involved in the stability of native protein structure in amorphous solids in relation to levels of hydration by Hill, John J, Shalaev, Evgenyi Y, Zografi, George

“…The internal, dynamical fluctuations of protein molecules exhibit many of the features typical of polymeric and bulk small molecule glass forming systems. The…”
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Partially crystalline systems in lyophilization: II. Withstanding collapse at high primary drying temperatures and impact on protein activity recovery by Chatterjee, Koustuv, Shalaev, Evgenyi Y, Suryanarayanan, Raj

“…In an accompanying article we have described the construction of the water-rich sections of raffinose-glycine-water and trehalose-glycine-water state diagrams…”
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Raffinose crystallization during freeze-drying and its impact on recovery of protein activity by Chatterjee, Koustuv, Shalaev, Evgenyi Y, Suryanarayanan, Raj

“…To study i) phase transitions in raffinose solution in the frozen state and during freeze-drying and ii) evaluate the impact of raffinose crystallization on…”
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Partially crystalline systems in lyophilization: I. Use of ternary state diagrams to determine extent of crystallization of bulking agent by Chatterjee, Koustuv, Shalaev, Evgenyi Y, Suryanarayanan, Raj

“…Two model ternary systems: water-glycine-raffinose and water-glycine-trehalose were investigated to determine the extent of glycine crystallization in frozen…”
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Glass Transition of a Synthetic Phospholipid in the Lamellar Phase by Shalaev, Evgenyi Y., Steponkus, Peter L.

“…A synthetic phospholipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), was studied by differential scanning calorimetry at different hydration…”
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Polyamorphism: a pharmaceutical science perspective by Hancock, Bruno C., Shalaev, Evgenyi Y., Shamblin, Sheri L.

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The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients by Zinchuk, Andrey V., Hancock, Bruno C., Shalaev, Evgenyi Y., Reddy, Renuka D., Govindarajan, Ramprakash, Novak, Elizabeth

“…In this work the Hammett acidity function has been measured to assess the relative acidity of excipients used in the preparation of pharmaceutical solid dosage…”
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Depression of the Glass Transition Temperature of Sucrose Confined in a Phospholipid Mesophase by Shalaev, Evgenyi Y, Steponkus, Peter L

“…The glass transition of sucrose in 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)/sucrose mixtures was studied by differential scanning calorimetry…”
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Changes in the Physical State of Model Mixtures during Freezing and Drying: Impact on Product Quality by SHALAEV, EVGENYI YU, FRANKS, FELIX

“…The factors which govern the effective freeze-drying of pharmaceutical and biotechnological products are reviewed from the viewpoint of product formulation and…”
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Equilibrium phase diagram of the water-sucrose-NaCl system by Shalaev, E.Yu, Franks, F.

“…The solid-liquid equilibrium phase relationships in the ternary system water-NaCl-sucrose have been established with the aid of DSC measurements in the…”
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