Search Results - "Shalaev, E."

A procedure to optimize scale-up for the primary drying phase of lyophilization by Kramer, T, Kremer, D M, Pikal, M J, Petre, W J, Shalaev, E Y, Gatlin, L A

“…This article describes a procedure to facilitate scale-up for the primary drying phase of lyophilization using a combination of empirical testing and numerical…”
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Influence of sorbitol on protein crowding in solution and freeze-concentrated phases by Khodadadi, S, Clark, N J, McAuley, A, Cristiglio, V, Curtis, J E, Shalaev, E Y, Krueger, S

“…Small-angle neutron scattering was employed to study protein crowding under freezing conditions that mimic those used in pharmaceutical processing. The results…”
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How does residual water affect the solid-state degradation of drugs in the amorphous state? by Shalaev, E Y, Zografi, G

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Experimental Study and Modeling of Freeze-Drying in Syringe Configuration. Part II: Mass and Heat Transfer Parameters and Sublimation End-Points by Hottot, A., Andrieu, J., Hoang, V., Shalaev, E. Y., Gatlin, L. A., Ricketts, S.

“…This work concerns the experimental study in syringe configuration of the sublimation period for a model formulation under operating conditions commonly used…”
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Experimental Study and Modeling of Freeze-Drying in Syringe Configuration. Part I: Freezing Step by Hottot, A., Andrieu, J., Vessot, S., Shalaev, E., Gatlin, L. A., Ricketts, S.

“…This article concerns the experimental study and the modeling of the freezing step during freeze-drying of a model lyoprotectant formulation in syringe…”
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Acid-catalyzed inversion of sucrose in the amorphous state at very low levels of residual water by SHALAEV, E. Y, QUN LU, SHALAEVA, M, ZOGRAFI, G

“…Factors affecting the solid-state acid-catalyzed inversion of amorphous sucrose to glucose and fructose in the presence of colyophilized citric acid, with less…”
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Thermophysical properties of pharmaceutically compatible buffers at sub-zero temperatures: Implications for freeze-drying by SHALAEV, Evgenyi Y, JOHNSON-ELTON, Tiffany D, LIUQUAN CHANG, PIKAL, Michael J

“…To evaluate crystallization behavior and collapse temperature (Tg') of buffers in the frozen state, in view of its importance in the development of lyophilized…”
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Phase diagram of 1,2-dioleoylphosphatidylethanolamine (DOPE):water system at subzero temperatures and at low water contents by Shalaev, Evgenyi Y., Steponkus, Peter L.

“…The phase behavior of partially hydrated 1,2-dioleoylphosphatidylethanolamine (DOPE) has been studied using differential scanning calorimetry and X-ray…”
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The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients by Zinchuk, Andrey V., Hancock, Bruno C., Shalaev, Evgenyi Y., Reddy, Renuka D., Govindarajan, Ramprakash, Novak, Elizabeth

“…In this work the Hammett acidity function has been measured to assess the relative acidity of excipients used in the preparation of pharmaceutical solid dosage…”
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Phase behavior and glass transition of 1,2-dioleoylphosphatidylethanolamine (DOPE) dehydrated in the presence of sucrose by Shalaev, Evgenyi Y, Steponkus, Peter L

“…The effect of sucrose on the phase behavior of 1,2-dioleoylphosphatidylethanolamine (DOPE) as a function of hydration was studied using differential scanning…”
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Protection of a protein against irradiation-induced degradation by additives in the solid state by Shalaev, E, Reddy, R, Kimball, R.N, Weinschenk, M.F, Guinn, M, Margulis, L

“…The impact of ionizing radiation on a globular protein (porcine somatotropin, pST) in the solid state was studied using rate of dissolution, high-performance…”
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Effects of processing on the solid-state methyl transfer of tetraglycine methyl ester by Shalaev, Evgenyi Yu, Shalaeva, Marina, Byrn, Stephen R., Zografi, George

“…The thermally induced solid-state methyl transfer of tetraglycine methyl ester (TGME) was followed by HPLC analysis for samples subjected to freeze-drying and…”
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Correction of the sample weight in hermetically sealed DSC pans by Shalaev, Evgenyi Y, Steponkus, Peter L

“…The weight of a DSC sample is routinely determined as the difference between the weight of the pan containing the sample and the empty pan. If the sample is…”
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Equilibrium phase diagram of the water-sucrose-NaCl system by Shalaev, E.Yu, Franks, F.

“…The solid-liquid equilibrium phase relationships in the ternary system water-NaCl-sucrose have been established with the aid of DSC measurements in the…”
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Acid-base characteristics of bromophenol blue-citrate buffer systems in the amorphous state by Li, Jinjiang, Chatterjee, Koustuv, Medek, Ales, Shalaev, Evgenyi, Zografi, George

“…In this study, we have examined the acid-base characteristics of various citrate buffer systems alone and in the presence of the pH indicator dye, bromophenol…”
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The effect of disorder on the chemical reactivity of an organic solid, tetraglycine methyl ester: change of the reaction mechanism by Shalaev, Evgenyi, Shalaeva, Marina, Zografi, George

“…Many drugs undergo chemical changes in the solid state, and understanding chemical reactivity of organic crystals is a critical factor in the drug development…”
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Hydrolysis in Pharmaceutical Formulations by Waterman, Kenneth C., Adami, Roger C., Alsante, Karen M., Antipas, Amy S., Arenson, Dan R., Carrier, Rebecca, Hong, Jinyang, Landis, Margaret S., Lombardo, Franco, Shah, Jaymin C., Shalaev, Evgenyi, Smith, Scott W., Wang, Hai

“…This literature review presents hydrolysis of active pharmaceutical ingredients as well as the effects on dosage form stability due to hydrolysis of…”
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Thermodynamic and dynamic factors involved in the stability of native protein structure in amorphous solids in relation to levels of hydration by Hill, John J, Shalaev, Evgenyi Y, Zografi, George

“…The internal, dynamical fluctuations of protein molecules exhibit many of the features typical of polymeric and bulk small molecule glass forming systems. The…”
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Engineering the Photonic Density of States with metamaterials by Jacob, Z, Kim, J. Y, Naik, G. V, Boltasseva, A, Shalaev, E. Narimanov. V. M

“…The photonic density of states (PDOS), like its' electronic coun- terpart, is one of the key physical quantities governing a variety of phenom- ena and hence…”
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Partially crystalline systems in lyophilization: II. Withstanding collapse at high primary drying temperatures and impact on protein activity recovery by Chatterjee, Koustuv, Shalaev, Evgenyi Y, Suryanarayanan, Raj

“…In an accompanying article we have described the construction of the water-rich sections of raffinose-glycine-water and trehalose-glycine-water state diagrams…”
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