Search Results - "Shakushiro, Kohsuke"

Formulation Design and Evaluation of Liposomal Sepantronium Bromide (YM155), a Small-Molecule Survivin Suppressant, Based on Pharmacokinetic Modeling and Simulation by Shakushiro, Kohsuke, Kawano, Hiroki, Nakata, Mari, Kita, Aya, Maeda, Atsushi, Watanabe, Shunsuke, Sako, Kazuhiro, Oku, Naoto

“…Purpose Sepantronium bromide (YM155) is administered by 168-hour continuous infusions in clinical studies due to its time-dependent pharmacological efficacy…”
Get full text

Antitumor efficacy and biodistribution of liposomal sepantronium bromide (YM155), a novel small-molecule survivin suppressant by Kawano, Hiroki, Shakushiro, Kohsuke, Nakata, Mari, Kita, Aya, Maeda, Atsushi, Watanabe, Shunsuke, Sako, Kazuhiro, Oku, Naoto

“…[Display omitted] •Liposomal YM155 greatly improved the level of YM155 circulating in the blood.•Liposomal YM155 showed unexpectedly high accumulation in the…”
Get full text

Efficient scavenger receptor‐mediated uptake and cross‐presentation of negatively charged soluble antigens by dendritic cells by Shakushiro, Kohsuke, Yamasaki, Yasuomi, Nishikawa, Makiya, Takakura, Yoshinobu

“…Summary Exogenous antigens endocytosed in large amounts by antigen‐presenting cells (APC) are presented on major histocompatibility complex (MHC) class I…”
Get full text

Ion-Responsive Drug Delivery Systems by Yoshida, Takayuki, Shakushiro, Kohsuke, Sako, Kazuhiro

“…Some kinds of cations and anions are contained in body fluids such as blood, interstitial fluid, gastrointestinal juice, and tears at relatively high…”
Get more information

Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen by Ikenaga, Tomoko, Yamasaki, Yasuomi, Shakushiro, Kohsuke, Nishikawa, Makiya, Takakura, Yoshinobu

“…Antigen presentation on major histocompatibility complex (MHC) class I and subsequent priming of antigen-specific cytotoxic T lymphocytes (CTLs) are essential…”
Get full text