Search Results - "Shakhov, Alexander N"

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates by Krivokrysenko, Vadim I, Toshkov, Ilia A, Gleiberman, Anatoli S, Krasnov, Peter, Shyshynova, Inna, Bespalov, Ivan, Maitra, Ratan K, Narizhneva, Natalya V, Singh, Vijay K, Whitnall, Mark H, Purmal, Andrei A, Shakhov, Alexander N, Gudkov, Andrei V, Feinstein, Elena

“…There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in…”
Get full text

Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2) by Shakhov, Alexander N, Singh, Vijay K, Bone, Frederick, Cheney, Alec, Kononov, Yevgeniy, Krasnov, Peter, Bratanova-Toshkova, Troitza K, Shakhova, Vera V, Young, Jason, Weil, Michael M, Panoskaltsis-Mortari, Angela, Orschell, Christie M, Baker, Patricia S, Gudkov, Andrei, Feinstein, Elena

“…Bacterial lipoproteins (BLP) induce innate immune responses in mammals by activating heterodimeric receptor complexes containing Toll-like receptor 2 (TLR2)…”
Get full text

Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53 by Fedtsova, Natalia, Komarova, Elena A., Greene, Kellee F., Novototskaya, Liliya R., Molodtsov, Ivan, Brackett, Craig M., Strom, Evguenia, Gleiberman, Anatoli S., Shakhov, Alexander N., Gudkov, Andrei V.

“…Transplantation of bone marrow (BM) is made possible by the differential sensitivity of its stromal and hematopoietic components to preconditioning by…”
Get full text

Distinct Role of Surface Lymphotoxin Expressed by B Cells in the Organization of Secondary Lymphoid Tissues by Tumanov, Alexei V., Kuprash, Dmitry V., Lagarkova, Maria A., Grivennikov, Sergei I., Abe, Koichiro, Shakhov, Alexander N., Drutskaya, Ludmila N., Stewart, Colin L., Chervonsky, Alexander V., Nedospasov, Sergei A.

“…In order to definitively ascertain the functional contribution of lymphotoxin (LT) expressed by B cells, we produced mice with the LTβ gene deleted from B…”
Get full text

Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting by Tumanov, Alexei V., Grivennikov, Sergei I., Shakhov, Alexander N., Rybtsov, Stanislav A., Koroleva, Ekaterina P., Takeda, Junji, Nedospasov, Sergei A., Kuprash, Dmitry V.

“…Mice with inactivation of lymphotoxin β receptor (LTβR) system have profound defects in the development and maintenance of peripheral lymphoid organs. As…”
Get full text

Novel tumor necrosis factor‐knockout mice that lack Peyer's patches by Kuprash, Dmitry V., Tumanov, Alexei V., Liepinsh, Dmitry J., Koroleva, Ekaterina P., Drutskaya, Marina S., Kruglov, Andrei A., Shakhov, Alexander N., Southon, Eileen, Murphy, William J., Tessarollo, Lino, Grivennikov, Sergei I., Nedospasov, Sergei A.

“…We generated a novel tumor necrosis factor (TNF) null mutation using Cre‐loxP technology. Mice homozygous for this mutation differ from their “conventional”…”
Get full text

Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure by Krivokrysenko, Vadim I, Shakhov, Alexander N, Singh, Vijay K, Bone, Frederick, Kononov, Yevgeniy, Shyshynova, Inna, Cheney, Alec, Maitra, Ratan K, Purmal, Andrei, Whitnall, Mark H, Gudkov, Andrei V, Feinstein, Elena

“…Given an ever-increasing risk of nuclear and radiological emergencies, there is a critical need for development of medical radiation countermeasures (MRCs)…”
Get more information

SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling by Shakhov, Alexander N., Rybtsov, Stanislav, Tumanov, Alexei V., Shulenin, Sergey, Dean, Michael, Kuprash, Dmitry V., Nedospasov, Sergei A.

“…Lymphotoxin‐α (LTα) was originally linked to delayed‐type hypersensitivity and its production was later attributed to Th1, but not Th2 cells. Studies employing…”
Get full text

Redundancy in Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) Signaling In Vivo: Mice with Inactivation of the Entire TNF/LT Locus versus Single-Knockout Mice by Kuprash, Dmitry V., Alimzhanov, Marat B., Tumanov, Alexei V., Grivennikov, Sergei I., Shakhov, Alexander N., Drutskaya, Ludmila N., Marino, Michael W., Turetskaya, Regina L., Anderson, Arthur O., Rajewsky, Klaus, Pfeffer, Klaus, Nedospasov, Sergei A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Distinct and Nonredundant In Vivo Functions of TNF Produced by T Cells and Macrophages/Neutrophils: Protective and Deleterious Effects by Grivennikov, Sergei I., Tumanov, Alexei V., Liepinsh, Dmitry J., Kruglov, Andrei A., Marakusha, Boris I., Shakhov, Alexander N., Murakami, Takaya, Drutskaya, Ludmila N., Förster, Irmgard, Clausen, Björn E., Tessarollo, Lino, Ryffel, Bernhard, Kuprash, Dmitry V., Nedospasov, Sergei A.

“…Tumor necrosis factor (TNF, TNFα) is implicated in various pathophysiological processes and can be either protective, as in host defense, or deleterious, as in…”
Get full text

Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus by Liepinsh, Dmitry J., Kruglov, Andrei A., Galimov, Arthur R., Shakhov, Alexander N., Shebzukhov, Yuriy V., Kuchmiy, Anna A., Grivennikov, Sergei I., Tumanov, Alexei V., Drutskaya, Marina S., Feigenbaum, Lionel, Kuprash, Dmitry V., Nedospasov, Sergei A.

“…TNF, lymphotoxin (LT)‐α, LT‐β and LIGHT are members of a larger superfamily of TNF‐related cytokines that can cross‐utilize several receptors. Although LIGHT…”
Get full text

Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies by Shakhov, Alexander N., Lyakhov, Ilya G., Tumanov, Alexei V., Rubtsov, Anatoly V., Drutskaya, Ludmila N., Marino, Michael W., Nedospasov, Sergei A.

“…Mice with combined lymphotoxin‐α (LTα) and tumor necrosis factor (TNF) deficiencies show defects in the structure of peripheral lymphoid organs such as spleen,…”
Get full text

Immune response to MMTV infection by Acha-Orbea, Hans, Shakhov, Alexander N, Finke, Daniela

“…Mouse mammary tumor virus (MMTV) has developed a strategy of exploitation of the immune response. It infects dendritic cells and B cells and requires this…”
Get full text

Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo by Abe, Koichiro, Yarovinsky, Felix O., Murakami, Takaya, Shakhov, Alexander N., Tumanov, Alexei V., Ito, Daisuke, Drutskaya, Ludmila N., Pfeffer, Klaus, Kuprash, Dmitry V., Komschlies, Kristin L., Nedospasov, Sergei A.

“…TNF/LTα/LTβ (tumor necrosis factor/lymphotoxin-α/lymphotoxin-β) triple knockout (KO) mice show a significant reduction of dendritic cell (DC) number in the…”
Get full text

Expression profiling in knockout mice: lymphotoxin versus tumor necrosis factor in the maintenance of splenic microarchitecture by Shakhov, Alexander N, Nedospasov, Sergei A

“…Expression profiling provides a powerful approach to define the underlying molecular mechanisms in disease. Several techniques referred collectively to as gene…”
Get full text

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages by Shakhov, A N, Collart, M A, Vassalli, P, Nedospasov, S A, Jongeneel, C V

“…We have explored the cis-acting elements necessary for the LPS-mediated activation of the mouse TNF-alpha promoter by transfecting a set of 5' deletion mutants…”
Get full text

Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus by Acha-Orbea, Hans, Shakhov, Alexander N., Scarpellino, Leo, Kolb, Edith, Müller, Vreni, Vessaz-Shaw, Annelyse, Fuchs, Regula, Blöchlinger, Karen, Rollini, Pierre, Billotte, Jerome, Sarafidou, Maria, MacDonald, H. Robson, Diggelmann, Heidi

Get full text

Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission by Held, W, Waanders, G A, Shakhov, A N, Scarpellino, L, Acha-Orbea, H, MacDonald, H R

“…Endogenous and infectious mouse mammary tumor viruses (MMTVs) encode in their 3' long terminal repeat a protein that exerts superantigen activity; that is, it…”
Get more information

Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment by Ito, D, Back, T C, Shakhov, A N, Wiltrout, R H, Nedospasov, S A

“…Mice deficient in lymphotoxin (LT)-alpha lack peripheral lymph nodes and Peyer's patches and have profound defects in development of follicular dendritic cell…”
Get full text

Role of interferon-gamma in interleukin 12-induced pathology in mice by Car, BD, Eng, VM, Schnyder, B, LeHir, M, Shakhov, AN, Woerly, G, Huang, S, Aguet, M, Anderson, TD, Ryffel, B

“…Interleukin 12 (IL-12) activates natural killer (NK) and T cells with the secondary synthesis and release of interferon-gamma (IFN-gamma) and other cytokines…”
Get full text