Search Results - "Shaker, Mohamed E."

The contribution of sterile inflammation to the fatty liver disease and the potential therapies by Shaker, Mohamed E.

“…Hepatic inflammation is prevalent in several metabolic liver diseases. Recent scientific advances about the pathogenesis of metabolic liver diseases showed an…”
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The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers by Shaker, Mohamed E., Trawick, Bobby N., Mehal, Wajahat Z.

“…[Display omitted] Ischemia/reperfusion (I/R) injury constitutes a major reason for failure of liver surgeries and transplantation. I/R injury is more severe in…”
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Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis by Abdelhady, Rasha, Saber, Sameh, Ahmed Abdel-Reheim, Mustafa, Mohammad S Alamri, Mohannad, Alfaifi, Jaber, I E Adam, Masoud, A Saleh, Lobna, I Farag, Azza, A Elmorsy, Elsayed, S El-Wakeel, Hend, S Doghish, Ahmed, E Shaker, Mohamed, H Hazem, Sara, A Ramadan, Heba, S Hamad, Rabab, A Mohammed, Osama

“…Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that demonstrates a dramatically increasing incidence worldwide…”
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Assembling a Cinnamyl Pharmacophore in the C3-Position of Substituted Isatins via Microwave-Assisted Synthesis: Development of a New Class of Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease by Manoharan, Amritha, Oh, Jong Min, Benny, Feba, Kumar, Sunil, Abdelgawad, Mohamed A, Ghoneim, Mohammed M, Shaker, Mohamed E, El-Sherbiny, Mohamed, Almohaimeed, Hailah M, Gahtori, Prashant, Kim, Hoon, Mathew, Bijo

“…Monoamine oxidase (MAO, EC 1.4.3.4) is responsible for the oxidative breakdown of both endogenous and exogenous amines and exists in MAO-A and MAO-B isomers…”
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A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights by Al-Sanea, Mohammad M, Obaidullah, Ahmad J, Shaker, Mohamed E, Chilingaryan, Garri, Alanazi, Mohammed M, Alsaif, Nawaf A, Alkahtani, Hamad M, Alsubaie, Sultan A, Abdelgawad, Mohamed A

“…Cyclin-dependent kinases (CDKs) regulate mammalian cell cycle progression and RNA transcription. Based on the structural analysis of previously reported CDK2…”
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The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations by Musa, Arafa, Ihmaid, Saleh K., Hughes, David L., Said, Musa A., Abulkhair, Hamada S., El-Ghorab, Ahmed H., Abdelgawad, Mohamed A., Shalaby, Khaled, Shaker, Mohamed E., Alharbi, Khalid Saad, Alotaibi, Nasser Hadal, Kays, Deborah L., Taylor, Laurence J., Parambi, Della Grace Thomas, Alzarea, Sami I., Al-Karmalawy, Ahmed A., Ahmed, Hany E. A., El-Agrody, Ahmed M.

“…Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to the lack of effective targeted medications, often…”
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Combining the HSP90 inhibitor TAS-116 with metformin effectively degrades the NLRP3 and attenuates inflammasome activation in rats: A new management paradigm for ulcerative colitis by Shaaban, Ahmed A., Abdelhamid, Amir Mohamed, Shaker, Mohamed E., Cavalu, Simona, Maghiar, Adrian Marius, Alsayegh, Abdulrahman A., Babalghith, Ahmad O., El-Ahwany, Eman, Amin, Noha A., Mohammed, Osama A., Eissa, Hanan, Gaafar, Ahmed Gaafar Ahmed, Batiha, Gaber El-Saber, Saber, Sameh

“…Ulcerative colitis (UC) is a prevalent type of inflammatory bowel diseases that may predispose patients to acquire colitis-related cancer if treatment was not…”
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Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases by Shaker, Mohamed E., Ghani, Ayaz, Shiha, Gamal E., Ibrahim, Tarek M., Mehal, Wajahat Z.

“…Increasing hepatic stellate cell (HSC) death is a very attractive approach for limiting liver fibrosis. Tyrosine kinase inhibitors have been shown to have…”
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Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators by Shaker, Mohamed E., Hamed, Mohamed F., Shaaban, Ahmed A.

“…The cardiotonic digoxin has been recently shown to possess an anti-inflammatory potential in numerous metabolic and inflammatory disorders. However, data about…”
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Mitigation of acetaminophen-induced liver toxicity by the novel phosphatidylinositol 3-kinase inhibitor alpelisib by Shaker, Mohamed E., Gomaa, Hesham A. M., Hazem, Sara H., Abdelgawad, Mohamed A., El-Mesery, Mohamed, Shaaban, Ahmed A.

“…The sterile inflammatory response mediated by Toll-like receptors (TLRs) 4 and 9 is implicated in the massive hepatic damage caused by acetaminophen…”
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Inhibition of Bruton tyrosine kinase by acalabrutinib dampens lipopolysaccharide/galactosamine-induced hepatic damage by Shaker, Mohamed E., Gomaa, Hesham A.M., Alharbi, Khalid S., Al-Sanea, Mohammad M., El-Mesery, Mohamed E., Hazem, Sara H.

“…[Display omitted] •The effect of the BTK inhibitor acalabrutinib was tested on hepatic damage.•Acalabrutinib inhibited LPS/D-GaIN-induced hepatic injury and…”
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Corrigendum: Mitigation of acetaminophen-induced liver toxicity by the novel phosphatidylinositol 3-kinase inhibitor alpelisib by Shaker, Mohamed E., Gomaa, Hesham A. M., Hazem, Sara H., Abdelgawad, Mohamed A., El-Mesery, Mohamed, Shaaban, Ahmed A.

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Quality and shelf life of strawberry fruit as affected by edible coating by moringa leaf extract, aloe vera gel, oxalic acid, and ascorbic acid by Shafique, Muhammad, Rashid, Muhammad, Ullah, Sami, Rajwana, Ishtiaq Ahmad, Naz, Ambreen, Razzaq, Kashif, Hussain, Muzzamal, Abdelgawad, Mohamed A., El-Ghorab, Ahmed H., Ghoneim, Mohammed M., Shaker, Mohamed E., Imran, Muhammad, Jbawi, Entessar Al

“…In the current study, the most effective concentrations of moringa leaf extract (MLE), aloe vera gel (AV gel), ascorbic acid (1 mM) and oxalic acid (5 mM) were…”
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Inhibitions of monoamine oxidases by ferulic acid hydrazide derivatives: synthesis, biochemistry, and computational evaluation by Peedikayil, Arshida Thottile, Lee, Jiseong, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., Shaker, Mohamed E., Selim, Samy, Kumar, Sunil, Dev, Sanal, Kim, Hoon, Mathew, Bijo

“…Monoamine oxidases (MAOs) regulate neurotransmitters, and changes in their regulation lead to neurogenerative diseases (NDs). Therefore, MAO inhibitors are…”
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Anticancer perspectives of genistein: a comprehensive review by Naeem, Hammad, Momal, Ushna, Imran, Muhammad, Shahbaz, Muhammad, Hussain, Muzzamal, Alsagaby, Suliman A., Al Abdulmonem, Waleed, Umar, Maryam, Mujtaba, Ahmad, El-Ghorab, Ahmed H., Ghoneim, Mohammed M., Shaker, Mohamed E., Abdelgawad, Mohamed A., AL JBawi, Entessar

“…There is a significant load of degenerative and chronic illnesses, especially cancer, which is one of the main reasons for morbidity and death globally…”
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Anti-cancer perspectives of resveratrol: a comprehensive review by Anwar, Muhammad Junaid, Altaf, Areeba, Imran, Muhammad, Amir, Muhammad, Alsagaby, Suliman A., Abdulmonem, Waleed Al, Mujtaba, Ahmed, El-Ghorab, Ahmed H., Ghoneim, Mohammed M., Hussain, Muzzamal, Jbawi, Entessar Al, Shaker, Mohamed E., Abdelgawad, Mohamed A.

“…Resveratrol (RVT) is well known for its chemo-preventive and therapeutic attributes against the various kinds of cancers such as breast, prostate, pancreatic,…”
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Utilization of mango seed oil as a cocoa butter replacer for the development of innovative chocolate by Abbas, Suleman, Shahbaz, Muhammad, Ahmad, Shabbir, Imran, Muhammad, Naeem, Hammad, Hussain, Muzzamal, Mujtaba, Ahmed, Mubeen, Khuram, Afzal, Muhammad Inam, Akram, Qaiser, Mushtaq, Zarena, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., Shaker, Mohamed E., AL JBawi, Entessar

“…Chocolate is the most popular food type and flavor in this world. The key ingredient in many chocolate products is cocoa butter due to its unique fatty acid…”
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Anticancer and apoptosis inducing potential of quercetin against a wide range of human malignancies by Shahbaz, Muhammad, Naeem, Hammad, Momal, Ushna, Imran, Muhammad, Alsagaby, Suliman A., Al Abdulmonem, Waleed, Waqar, Ahmed Bilal, El-Ghorab, Ahmed H., Ghoneim, Mohammed M., Abdelgawad, Mohamed A., Shaker, Mohamed E., Umar, Maryam, Hussain, Muzzamal, Kumar, Roshan, Al Jbawi, Entessar

“…Quercetin, a flavonoid, is a dietary component that has attracted the attention of dietitians and medicinal chemists due to its anticancer potential. It is an…”
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Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by Shaker, Mohamed E., Zalata, Khaled R., Mehal, Wajahat Z., Shiha, Gamal E., Ibrahim, Tarek M.

“…Effective and well-tolerated anti-fibrotic drugs are currently lacking. Therefore, this study was carried out to investigate the potential anti-fibrotic…”
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Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors by Jayan, Jayalakshmi, Chandran, Namitha, Thekkantavida, Amrutha Chandran, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., Shaker, Mohamed E., Uniyal, Prerna, Benny, Feba, Zachariah, Subin Mary, Kumar, Sunil, Kim, Hoon, Mathew, Bijo

“…The monoamine oxidase enzyme (MAO), which is bound on the membrane of mitochondria, catalyzes the oxidative deamination of endogenous and exogenous monoamines,…”
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