Search Results - "Shaked, G.M"

Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624) by Shaked, G.M, Kummer, M.P, Lu, D.C, Galvan, V, Bredesen, D.E, Koo, E.H

“…Amyloid β-peptide (Aβ) is postulated to play a central role in the pathogenesis of Alzheimer's disease. We recently proposed a pathway of Aβ-induced toxicity…”
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Interactions between the APP C-terminal domain and G-proteins mediate calcium dysregulation and Aβ toxicity in Alzheimer disease by Shaked, G.M, Chauv, S, Ubhi, K, Hansen, L.A, Masliah, E

“…Alzheimer’s Disease (AD) is characterized by neuropathological accumulations of Amyloid-β 1–42 (Aβ 1–42 ), a cleavage product of the Amyloid Precursor Protein…”
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