Search Results - "Shaji, Chinchusha Anasooya"

The Tri-phasic Role of Hydrogen Peroxide in Blood-Brain Barrier Endothelial cells by Anasooya Shaji, Chinchusha, Robinson, Bobby D., Yeager, Antonia, Beeram, Madhava R., Davis, Matthew L., Isbell, Claire L., Huang, Jason H., Tharakan, Binu

“…Hydrogen peroxide (H 2 O 2 ) plays an important role physiologically as the second messenger and pathologically as an inducer of oxidative stress in injury,…”
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Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition by Alluri, Himakarnika, Wilson, Rickesha L, Anasooya Shaji, Chinchusha, Wiggins-Dohlvik, Katie, Patel, Savan, Liu, Yang, Peng, Xu, Beeram, Madhava R, Davis, Matthew L, Huang, Jason H, Tharakan, Binu

“…Microvascular hyperpermeability that occurs at the level of the blood-brain barrier (BBB) often leads to vasogenic brain edema and elevated intracranial…”
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Neuroimmune Activation and Microglia Reactivity in Female Rats Following Alcohol Dependence by Melbourne, Jennifer K, Wooden, Jessica I, Carlson, Erika R, Anasooya Shaji, Chinchusha, Nixon, Kimberly

“…The rates of alcohol use disorder among women are growing, yet little is known about how the female brain is affected by alcohol. The neuroimmune system, and…”
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Doxycycline prevents blood–brain barrier dysfunction and microvascular hyperpermeability after traumatic brain injury by Robinson, Bobby D., Isbell, Claire L., Melge, Anu R., Lomas, Angela M., Shaji, Chinchusha Anasooya, Mohan, C. Gopi, Huang, Jason H., Tharakan, Binu

“…The main objective of this study was to determine the cellular and molecular effects of doxycycline on the blood–brain barrier (BBB) and protection against…”
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Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition by Alluri, Himakarnika, Grimsley, Marcene, Anasooya Shaji, Chinchusha, Varghese, Kevin Paul, Zhang, Shenyuan L., Peddaboina, Chander, Robinson, Bobby, Beeram, Madhava R., Huang, Jason H., Tharakan, Binu

“…Blood-brain barrier (BBB) breakdown and the associated microvascular hyperpermeability followed by brain edema are hallmark features of several brain…”
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Reactive, Adult Neurogenesis From Increased Neural Progenitor Cell Proliferation Following Alcohol Dependence in Female Rats by Nawarawong, Natalie N., Thompson, K. Ryan, Guerin, Steven P., Anasooya Shaji, Chinchusha, Peng, Hui, Nixon, Kimberly

“…Hippocampal neurodegeneration is a consequence of excessive alcohol drinking in alcohol use disorders (AUDs), however, recent studies suggest that females may…”
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Adolescent Intermittent Ethanol Drives Modest Neuroinflammation but Does Not Escalate Drinking in Male Rats by Wooden, Jessica I, Peacoe, Lauren E, Anasooya Shaji, Chinchusha, Melbourne, Jennifer K, Chandler, Cassie M, Bardo, Michael T, Nixon, Kimberly

“…During adolescence, the brain is highly susceptible to alcohol-induced damage and subsequent neuroimmune responses, effects which may enhance development of an…”
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Quetiapine protects the blood-brain barrier in traumatic brain injury by Robinson, Bobby Darnell, Isbell, Claire Larson, Anasooya Shaji, Chinchusha, Kurek, Jr, Stanley, Regner, Justin L, Tharakan, Binu

“…The integrity of the blood-brain barrier (BBB) is paramount in limiting vasogenic edema following traumatic brain injury (TBI). The purpose of this study was…”
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Oxygen-glucose deprivation and reoxygenation as an in vitro ischemia-reperfusion injury model for studying blood-brain barrier dysfunction by Alluri, Himakarnika, Anasooya Shaji, Chinchusha, Davis, Matthew L, Tharakan, Binu

“…Ischemia-Reperfusion (IR) injury is known to contribute significantly to the morbidity and mortality associated with ischemic strokes. Ischemic cerebrovascular…”
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Doxycycline Attenuates Lipopolysaccharide-Induced Microvascular Endothelial Cell Derangements by Wiggins-Dohlvik, Katie, Stagg, Hayden W, Han, Min Suk, Alluri, Himakarnika, Oakley, Ryan P, Anasooya Shaji, Chinchusha, Davis, Matthew L, Tharakan, Binu

“…INTRODUCTION:Lipopolysaccharide (LPS) is known to induce vascular derangements. The pathophysiology involved therein is unknown, but matrix metalloproteinases…”
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Dopamine Regulates Blood‐Brain Barrier Endothelial Cell Hyperpermeability by Kosel, Kelby, Shaji, Chinchusha Anasooya, Zemmedhun, Gelilla, Tharakan, Binu

“…Blood‐Brain Barrier (BBB) dysfunction leading to hyperpermeability is one of the major causes of brain edema following conditions such as traumatic and…”
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Astrocyte Reactivity and Neurodegeneration in the Female Rat Brain Following Alcohol Dependence by Guerin, Steven P., Melbourne, Jennifer K., Dang, Huy Q., Shaji, Chinchusha Anasooya, Nixon, Kimberly

“…[Display omitted] •We observed subtle sex differences in brains of female rats after alcohol dependence.•Neurodegeneration occurred in similar corticolimbic…”
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A tri‐phasic role for hydrogen peroxide in blood‐brain barrier endothelial cells by Shaji, Chinchusha Anasooya, Robinson, Bobby, Yeager, Antonia, Beeram, Madhava, Isbell, Claire L., Tharakan, Binu

“…Abstract only In microvascular endothelial cells, hydrogen peroxide (H 2 O 2 ) plays an important role as a signaling second messenger as well as an inducer of…”
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Doxycycline Blocks Matrixmetalloproteinase‐9 and Attenuates Blood‐Brain Barrier dysfunction and Hyperpermeability after Traumatic Brain Injury by Robinson, Bobby Darnell, Lomas, Angela, Shaji, Chinchusha Anasooya, Isbell, Claire Larson, Tharakan, Binu

“…Abstract only Traumatic brain injury (TBI) is a global issue affecting approximately 10 million people annually. Brain edema that occurs after TBI leads to…”
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Blood‐Brain Barrier Dysfunction and Microvascular Hyperpermeability Following Mild Traumatic Brain Injury by Tharakan, Binu, Alluri, Himakarnika, Shaji, Chinchusha Anasooya, Wiggins‐Dohlvik, Katie, Beeram, Madhava R, Davis, Matthew L

“…Abstract only Microvascular hyperpermeability, the excessive leakage of fluid and proteins from intravascular space to the interstitium is the leading cause of…”
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Melatonin Preserves Blood‐brain Barrier Integrity and Permeability via Matrix Metalloproteinase‐9 Inhibition by Shaji, Chinchusha Anasooya, Alluri, Himakarnika, Wiggins‐Dohlvik, Katie, Beeram, Madhava R, Davis, Matthew L, Tharakan, Binu L

“…Abstract only Microvascular hyperpermeability that occurs at the level of the blood‐brain barrier (BBB) often leads to vasogenic brain edema following…”
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Exploring blood-brain barrier hyperpermeability and potential biomarkers in traumatic brain injury by Robinson, Bobby Darnell, Tharakan, Binu, Lomas, Angela, Wiggins-Dohlvik, Katie, Alluri, Himakarnika, Shaji, Chinchusha Anasooya, Jupiter, Daniel, Isbell, Claire Larson

“…Blood-brain barrier breakdown and associated vascular hyperpermeability leads to vasogenic edema in traumatic brain injury (TBI). Tight junctions maintain…”
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Melatonin inhibits thermal injury-induced hyperpermeability in microvascular endothelial cells by Wiggins-Dohlvik, Katie, Han, Min Suk, Stagg, Hayden W, Alluri, Himakarnika, Shaji, Chinchusha Anasooya, Oakley, Ryan P, Davis, Matthew L, Tharakan, Binu

“…Burns induce systemic inflammatory reactions and vascular hyperpermeability. Breakdown of endothelial cell adherens junctions is integral in this process, and…”
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Interleukin‐1β induces brain microvascular endothelial cell hyperpermeability through matrix metalloproteinase‐9 (678.17) by Alluri, Himakarnika, Anasooya Shaji, Chinchusha, Wiggins‐Dohlvik, Katie, Oakley, Ryan, Stagg, Hayden, Davis, Matthew, Tharakan, Binu

“…Interleukin‐1β induces Brain Microvascular Endothelial Cell Hyperpermeability through Matrix metalloproteinase‐9 Himakarnika Alluri, Chinchusha Anasooya Shaji,…”
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6: MELATONIN INHIBITS HEMORRHAGIC SHOCK INDUCED FLUID LEAK AND MICROVASCULAR ENDOTHELIAL DERANGEMENTS by Wiggins-Dohlvik, Katie, Alluir, Himakarnika, Shaji, Chinchusha Anasooya, Govande, Vivayak, Beeram, Madhava, Mohammad, Amin, Davis, Matthew, Tharakan, Binu

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