Search Results - "Shaik, Shama"
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A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
Published in Scientific reports (26-02-2018)“…Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from the co-factor S-adenosyl-L-methionine (SAM)…”
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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Published in Bioorganic & medicinal chemistry letters (01-03-2018)“…Compound 12 Human/mouse NNMT enzymatic inhibition (IC50): 0.58/4.5 µM. Inhibition of MNA in U2OS/3T3L1 cell based assay: 0.3/2.1 µM. Human/mouse metabolic…”
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A novel in-cell ELISA method for screening of compounds inhibiting TRKA phosphorylation, using KM12 cell line harboring TRKA rearrangement
Published in Analytical biochemistry (15-03-2018)“…Tropomyosin-related kinase A (TRKA) fusion was originally detected in colorectal carcinoma that had resulted in expression of the oncogenic chimeric protein…”
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Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
Published in Biochemical and biophysical research communications (16-09-2017)“…Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-l-methionine (SAM)-dependent enzyme that catalyzes N-methylation of nicotinamide (NA) and other…”
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Formulation and evaluation of herbal anti-acne moisturizer
Published in Pakistan journal of pharmaceutical sciences (01-10-2012)“…The moisture content present in human skin makes it look young and the use of moisturizer results in fastening the moisture with a surface film of oil. Acne…”
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Investigation of Gold Nanoparticles Functionalized Silicon for Sensing Biomarkers of Lung Cancer Using Density Functional Theory
Published in 2024 IEEE Students Conference on Engineering and Systems (SCES) (21-06-2024)“…This study investigates the potential of Silicon functionalized with gold nanoparticles in sensing major lung cancer biomarkers like Acetone, Toluene and…”
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Conference Proceeding -
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Administration of Nanovaccines by Transdermal Drug Delivery System-current and Future Perspectives
Published in Asian journal of pharmaceutics (15-06-2024)Get full text
Journal Article