Search Results - "Shaik, Naveed"

Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS by Savona, Michael R, Pollyea, Daniel A, Stock, Wendy, Oehler, Vivian G, Schroeder, Mark A, Lancet, Jeffrey, McCloskey, James, Kantarjian, Hagop M, Ma, Weidong Wendy, Shaik, M Naveed, Laird, A Douglas, Zeremski, Mirjana, O'Connell, Ashleigh, Chan, Geoffrey, Cortes, Jorge E

“…This open-label, multicenter, dose-finding, phase Ib study (NCT01546038) evaluated the safety, pharmacokinetics, pharmacodynamics, and clinical activity of the…”
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Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high‐risk MDS: Phase 2 study results by Cortes, Jorge E., Douglas Smith, B., Wang, Eunice S., Merchant, Akil, Oehler, Vivian G., Arellano, Martha, DeAngelo, Daniel J., Pollyea, Daniel A., Sekeres, Mikkael A., Robak, Tadeusz, Ma, Weidong Wendy, Zeremski, Mirjana, Naveed Shaik, M., Douglas Laird, A., O'Connell, Ashleigh, Chan, Geoffrey, Schroeder, Mark A.

“…Glasdegib is a Hedgehog pathway inhibitor. This ongoing, open‐label, phase 2 study (NCT01546038) evaluated glasdegib plus cytarabine/daunorubicin in patients…”
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Current State and Opportunities with Long-acting Injectables: Industry Perspectives from the Innovation and Quality Consortium “Long-Acting Injectables” Working Group by Bauer, Andrea, Berben, Philippe, Chakravarthi, Sudhir S., Chattorraj, Sayantan, Garg, Ashish, Gourdon, Betty, Heimbach, Tycho, Huang, Ye, Morrison, Christopher, Mundhra, Deepak, Palaparthy, Ramesh, Saha, Pratik, Siemons, Maxime, Shaik, Naveed A., Shi, Yi, Shum, Sara, Thakral, Naveen K., Urva, Shweta, Vargo, Ryan, Koganti, Venkat R., Barrett, Stephanie E.

“…Long-acting injectable (LAI) formulations can provide several advantages over the more traditional oral formulation as drug product opportunities. LAI…”
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Evaluation of the impact of renal impairment on the pharmacokinetics of glasdegib in otherwise healthy volunteers by Shaik, Naveed, LaBadie, Robert R., Hee, Brian, Chan, Geoffrey

“…Purpose Glasdegib is being developed for indications in myeloid malignancies. The effect of renal impairment on the pharmacokinetics (PK) of a single, oral,…”
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P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib by Chen, Ying, Agarwal, Sagar, Shaik, Naveed M, Chen, Cliff, Yang, Zheng, Elmquist, William F

“…The novel tyrosine kinase inhibitor dasatinib (Sprycel; BMS-354825) is approved for use in imatinib (Gleevec; STI 571)-resistant or -intolerant chronic…”
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Pharmacokinetics, Mass Balance, Safety, and Tolerability of Obeldesivir in Healthy Participants by Anoshchenko, Olena, Abdelghany, Mazin, Lichtman, Amos, Duan, Ran, Chen, Henry, Shaik, Naveed A., Peng, Chi‐Chi, Yue, Qin, Subramanian, Raju, Hyland, Robert H., Davies, Santosh, Castellanos, Keelin, Mak, Lily, Shen, Gong, Xiao, Deqing, Caro, Luzelena, Winter, Helen, Llewellyn, Joe, Humeniuk, Rita

“…There is an unmet need for safe and efficacious oral therapies for COVID‐19 with low potential for drug–drug interactions. Obeldesivir is an orally…”
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Evaluation of the effects of formulation, food, or a proton-pump inhibitor on the pharmacokinetics of glasdegib (PF-04449913) in healthy volunteers: a randomized phase I study by Shaik, Naveed, Hee, Brian, Wei, Hua, LaBadie, Robert R.

“…Purpose To demonstrate the bioequivalence of the planned maleate salt-based commercial glasdegib tablet formulation [International Council for Harmonization…”
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PK/PD model‐informed dose selection for oncology phase I expansion: Case study based on PF‐06939999, a PRMT5 inhibitor by Guo, Cen, Liao, Kai H., Li, Meng, Wang, I‐Ming, Shaik, Naveed, Yin, Donghua

“…The optimal dose for targeted oncology therapeutics is often not the maximum tolerated dose. Pharmacokinetic/pharmacodynamic (PK/PD) modeling can be an…”
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Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers by Shaik, M. Naveed, LaBadie, Robert R., Rudin, Dan, Levin, Wendy J.

“…Purpose To evaluate the effect of a potent cytochrome P450 3A4 (CYP3A4) inhibitor, ketoconazole, and separately the effect of food on PF-04449913…”
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Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study by Martinelli, Giovanni, MD, Oehler, Vivian G, MD, Papayannidis, Cristina, MD, Courtney, Rachel, PhD, Shaik, M Naveed, PhD, Zhang, Xiaoxi, PhD, O'Connell, Ashleigh, BSc, McLachlan, Karen R, PhD, Zheng, Xianxian, PhD, Radich, Jerald, Prof, Baccarani, Michele, Prof, Kantarjian, Hagop M, Prof, Levin, Wendy J, MD, Cortes, Jorge E, Prof, Jamieson, Catriona, Dr

“…Summary Background Activation of the Hedgehog signalling pathway contributes to cancer progression and the development of myeloid leukaemia stem cell…”
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P-glycoprotein-Mediated Active Efflux of the Anti-HIV1 Nucleoside Abacavir Limits Cellular Accumulation and Brain Distribution by SHAIK, Naveed, GIRI, Nagdeep, GUOYU PAN, ELMQUIST, William F

“…P-glycoprotein (P-gp)-mediated efflux at the blood-brain barrier has been implicated in limiting the brain distribution of many anti-HIV1 drugs, primarily…”
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Investigation of the micellar effect of pluronic P85 on P-glycoprotein inhibition: cell accumulation and equilibrium dialysis studies by Shaik, Naveed, Giri, Nagdeep, Elmquist, William F

“…The objective of this study was: (1) to characterize the P-gp inhibitory effect of different concentrations of Pluronic P85 on anti-HIV-1 drug cellular…”
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Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design by GIRI, Nagdeep, AGARWAL, Sagar, SHAIK, Naveed, GUOYU PAN, YING CHEN, ELMQUIST, William F

“…In vitro assays are frequently used for the screening of substrates and inhibitors of transporter-mediated efflux. Examining directional flux across…”
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Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse by GIRI, Nagdeep, SHAIK, Naveed, GUOYU PAN, TERASAKI, Tetsuya, MUKAI, Chisato, KITAGAKI, Shinji, MIYAKOSHI, Naoki, ELMQUIST, William F

“…Many anti-human immunodeficiency virus 1 nucleoside reverse-transcriptase inhibitors have low central nervous system (CNS) distribution due in part to active…”
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Mechanism of Drug-Drug Interactions Between Warfarin and Statins by Shaik, Abdul Naveed, Bohnert, Tonika, Williams, David A, Gan, Lawrence L, LeDuc, Barbara W

“…The anticoagulant drug warfarin and the lipid-lowering statin drugs are commonly co-administered to patients with cardiovascular diseases. Clinically…”
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Development and validation of a LC–MS/MS assay for quantification of cisplatin in rat plasma and urine by Shaik, Abdul Naveed, Altomare, Deborah A., Lesko, Lawrence J., Trame, Mirjam N.

“…•Cisplatin LC–MS/MS Method Validation using Agilent 6460 triple quad.•Derivatization of cisplatin with diethyldithiocarbamate for indirect estimation of…”
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Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome by Cortes, Jorge E., Heidel, Florian H., Hellmann, Andrzej, Fiedler, Walter, Smith, B. Douglas, Robak, Tadeusz, Montesinos, Pau, Pollyea, Daniel A., DesJardins, Pierre, Ottmann, Oliver, Ma, Weidong Wendy, Shaik, M. Naveed, Laird, A. Douglas, Zeremski, Mirjana, O’Connell, Ashleigh, Chan, Geoffrey, Heuser, Michael

“…Glasdegib is a Hedgehog pathway inhibitor. This phase II, randomized, open-label, multicenter study (ClinicalTrials.gov, NCT01546038) evaluated the efficacy of…”
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Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: Quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile by Basha, Shaik Jafar Sadik, Naveed, Shaik Abdul, Tiwari, Nirbhay Kumar, Shashikumar, Dhanya, Muzeeb, Syed, Kumar, Thammera Ranjith, Kumar, Nyavanandi Vijay, Rao, Nadipalli Prabhakar, Srinivas, Nanduri, Mullangi, Ramesh, Srinivas, Nuggehally R.

“…Simultaneous separation and quantification of ezetimibe (EZM) and its phase-I metabolite i.e., ezetimibe ketone (EZM-K) and phase-II metabolite i.e., ezetimibe…”
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Comparison of enzyme kinetics of warfarin analyzed by LC–MS/MS QTrap and differential mobility spectrometry by Shaik, Abdul Naveed, Grater, Richard, Lulla, Mukesh, Williams, David A., Gan, Lawrence L., Bohnert, Tonika, LeDuc, Barbara W.

“…•This work is the first to separate all the six hydroxylated metabolites of warfarin including 3′,4′,6,7,8,10-hydroxy warfarin, and the parent in single…”
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Isocitrate dehydrogenase of Helicobacter pylori potentially induces humoral immune response in subjects with peptic ulcer disease and gastritis by Hussain, M Abid, Naveed, Shaik A, Sechi, Leonardo A, Ranjan, Sarita, Alvi, Ayesha, Ahmed, Irshad, Ranjan, Akash, Mukhopadhyay, Sangita, Ahmed, Niyaz

“…H. pylori causes gastritis and peptic ulcers and is a risk factor for the development of gastric carcinoma. Many of the proteins such as urease, porins,…”
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