Search Results - "Shaik, B."

Identification of hydantoin based Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) inhibitors as antimycobacterial agents using computational tools by Mali, Suraj N., Pandey, Anima, Bhandare, Richie R., Shaik, Afzal B.

“…Tuberculosis (TB) is one of the emerging infectious diseases in the world. DprE1 (Decaprenylphosphoryl-β- d -ribose 2′-epimerase), an enzyme accountable for…”
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A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies by Verma, Santosh Kumar, Verma, Rameshwari, Kumar, Kothanahally S.Sharath, Banjare, Laxmi, Shaik, Afzal B., Bhandare, Richie R., Rakesh, Kadalipura P., Rangappa, Kanchugarakoppal S.

“…Methicillin-resistant Staphylococcus aureus (MRSA) is becoming dangerous to human beings due to easy transmission mode and leading to the difficult-to-treat…”
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Thiazole-Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation by Kasetti, Ashok Babu, Singhvi, Indrajeet, Nagasuri, Ravindra, Bhandare, Richie R, Shaik, Afzal B

“…Compounds bearing thiazole and chalcone pharmacophores have been reported to possess excellent antitubercular and anticancer activities. In view of this, we…”
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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants by Marek, Martin, Shaik, Tajith B, Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Ramos-Morales, Elizabeth, Da Veiga, Cyrielle, Kalinin, Dmitrii, Melesina, Jelena, Robaa, Dina, Schmidtkunz, Karin, Suzuki, Takayoshi, Holl, Ralph, Ennifar, Eric, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang, Romier, Christophe

“…Metal-dependent histone deacetylases (HDACs) are key epigenetic regulators that represent promising therapeutic targets for the treatment of numerous human…”
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Treatment options for wastewater effluents from pharmaceutical companies by Deegan, A. M, Shaik, B, Nolan, K, Urell, K, Oelgemöller, M, Tobin, J, Morrissey, A

“…In recent years, concerns about the occurrence and fate of active pharmaceutical ingredients, solvents, intermediates and raw materials that could be present…”
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Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors by Vögerl, Katharina, Ong, Nghia, Senger, Johanna, Herp, Daniel, Schmidtkunz, Karin, Marek, Martin, Müller, Martin, Bartel, Karin, Shaik, Tajith B, Porter, Nicholas J, Robaa, Dina, Christianson, David W, Romier, Christophe, Sippl, Wolfgang, Jung, Manfred, Bracher, Franz

“…The phenothiazine system was identified as a favorable cap group for potent and selective histone deacetylase 6 (HDAC6) inhibitors. Here, we report the…”
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Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis by Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Marek, Martin, Melesina, Jelena, Hauser, Alexander-Thomas, Shaik, Tajith B, Duclaud, Sylvie, Robaa, Dina, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang

“…Schistosomiasis is a major neglected parasitic disease that affects more than 265 million people worldwide and for which the control strategy consists of mass…”
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QSAR and Molecular Docking Studies of Pyrimidine-Coumarin-Triazole Conjugates as Prospective Anti-Breast Cancer Agents by Subramani, Arun Kumar, Sivaperuman, Amuthalakshmi, Natarajan, Ramalakshmi, Bhandare, Richie R, Shaik, Afzal B

“…Cancer is a life-threatening disease and is the second leading cause of death worldwide. Although many drugs are available for the treatment of cancer,…”
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Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities by Shaik, Afzal B, Bhandare, Richie R, Nissankararao, Srinath, Edis, Zehra, Tangirala, N Ravikiran, Shahanaaz, Shaik, Rahman, M Mukhlesur

“…Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally…”
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Design, Synthesis, and Antibacterial and Antifungal Activities of Novel Trifluoromethyl and Trifluoromethoxy Substituted Chalcone Derivatives by Lagu, Surendra Babu, Yejella, Rajendra Prasad, Bhandare, Richie R, Shaik, Afzal B

“…Despite the availability of many drugs to treat infectious diseases, the problems like narrow antimicrobial spectrum, drug resistance, hypersensitivities and…”
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In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity by Elmaaty, Ayman Abo, Darwish, Khaled M, Chrouda, Amani, Boseila, Amira A, Tantawy, Mohamed A, Elhady, Sameh S, Shaik, Afzal B, Mustafa, Muhamad, Al-Karmalawy, Ahmed A

“…Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated to rise in the next years. On the other hand, vascular endothelial…”
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A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment by Bel-Bahar, Tarik S., Khan, Anam A., Shaik, Riaz B., Parvaz, Muhammad A.

“…Substance use disorders (SUDs) constitute a growing global health crisis, yet many limitations and challenges exist in SUD treatment research, including the…”
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Molecular mechanisms underlying the regulation of tumour suppressor genes in lung cancer by Lee, Jia Yee, Bhandare, Richie R., Boddu, Sai H.S., Shaik, Afzal B., Saktivel, Lakshmana Prabu, Gupta, Gaurav, Negi, Poonam, Barakat, Muna, Singh, Sachin Kumar, Dua, Kamal, Chellappan, Dinesh Kumar

“…Tumour suppressor genes play a cardinal role in the development of a large array of human cancers, including lung cancer, which is one of the most frequently…”
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Humoral and Cellular Immune Response Elicited by the BNT162b2 COVID-19 Vaccine Booster in Elderly by Dalla Gasperina, Daniela, Veronesi, Giovanni, Castelletti, Carlo M, Varchetta, Stefania, Ottolini, Sabrina, Mele, Dalila, Ferrari, Giuseppe, Shaik, Amruth K. B, Celesti, Fabrizio, Dentali, Francesco, Accolla, Roberto S, Forlani, Greta

“…Although the safety and efficacy of COVID-19 vaccines in older people are critical to their success, little is known about their immunogenicity among elderly…”
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A Critical Review on Therapeutic Potential of Benzimidazole Derivatives: A Privileged Scaffold by Natarajan, Ramalakshmi, Kumar, Padma, Subramani, Arunkumar, Siraperuman, Amuthalakshmi, Angamuthu, Prabakaran, Bhandare, Richie R, Shaik, Afzal B

“…Benzimidazole nucleus is a predominant heterocycle displaying a wide spectrum of pharmacological activities. The privileged nature of the benzimidazole…”
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Serotype epidemiology and antibiotic resistance of pneumococcal isolates colonizing infants in Botswana (2016-2019) by Hurst, Jillian H, Shaik-Dasthagirisaheb, Yazdani B, Truong, Loc, Boiditswe, Sefelani C, Patel, Sweta M, Gilchrist, Jodi, Maciejewski, Julia, Luinstra, Kathy, Smieja, Marek, Steenhoff, Andrew P, Cunningham, Coleen K, Pelton, Stephen I, Kelly, Matthew S

“…In 2012, Botswana introduced 13-valent pneumococcal conjugate vaccine (PCV-13) to its childhood immunization program in a 3+0 schedule, achieving coverage…”
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The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains by Vitoria Gomes, Marina, Landwerlin, Pauline, Diebold-Durand, Marie-Laure, Shaik, Tajith B., Durand, Alexandre, Troesch, Edouard, Weber, Chantal, Brillet, Karl, Lemée, Marianne Victoria, Decroos, Christophe, Dulac, Ludivine, Antony, Pierre, Watrin, Erwan, Ennifar, Eric, Golzio, Christelle, Romier, Christophe

“…Cohesin is key to eukaryotic genome organization and acts throughout the cell cycle in an ATP-dependent manner. The mechanisms underlying cohesin ATPase…”
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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing by Simoben, Conrad V, Robaa, Dina, Chakrabarti, Alokta, Schmidtkunz, Karin, Marek, Martin, Lancelot, Julien, Kannan, Srinivasaraghavan, Melesina, Jelena, Shaik, Tajith B, Pierce, Raymond J, Romier, Christophe, Jung, Manfred, Sippl, Wolfgang

“…A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic…”
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Linking language features to clinical symptoms and multimodal imaging in individuals at clinical high risk for psychosis by Haas, S S, Doucet, G E, Garg, S, Herrera, S N, Sarac, C, Bilgrami, Z R, Shaik, R B, Corcoran, C M

“…Abnormalities in the semantic and syntactic organization of speech have been reported in individuals at clinical high-risk (CHR) for psychosis. The current…”
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Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review by Sanapalli, Bharat Kumar Reddy, Ashames, Akram, Sigalapalli, Dilep Kumar, Shaik, Afzal B, Bhandare, Richie R, Yele, Vidyasrilekha

“…Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor,…”
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