Search Results - "Shahrara, Shiva"

CCL21/CCR7 signaling in macrophages promotes joint inflammation and Th17-mediated osteoclast formation in rheumatoid arthritis by Van Raemdonck, Katrien, Umar, Sadiq, Palasiewicz, Karol, Volkov, Suncica, Volin, Michael V., Arami, Shiva, Chang, Huan J., Zanotti, Brian, Sweiss, Nadera, Shahrara, Shiva

“…In rheumatoid arthritis (RA), synovial tissue abundantly expresses CCL21, a chemokine strongly associated with RA susceptibility. In this study, we aimed to…”
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The pathogenic role of angiogenesis in rheumatoid arthritis by Elshabrawy, Hatem A., Chen, Zhenlong, Volin, Michael V., Ravella, Shalini, Virupannavar, Shanti, Shahrara, Shiva

“…Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a critical role in the pathogenesis of several inflammatory…”
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The pathogenic importance of CCL21 and CCR7 in rheumatoid arthritis by Van Raemdonck, Katrien, Umar, Sadiq, Shahrara, Shiva

“…•CCL21 is a risk factor for Rheumatoid arthritis (RA).•CCL21 is highly elevated in RA synovial fluid and attracts circulating monocytes into the inflamed…”
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Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types by Umar, Sadiq, Palasiewicz, Karol, Volin, Michael V., Romay, Bianca, Rahat, Rani, Tetali, Chandana, Arami, Shiva, Guma, Monica, Ascoli, Christian, Sweiss, Nadera, Zomorrodi, Ryan K., O’Neill, Luke A. J., Shahrara, Shiva

“…Recent studies have shown the significance of metabolic reprogramming in immune and stromal cell function. Yet, the metabolic reconfiguration of RA macrophages…”
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Interleukin‐34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony‐Stimulating Factor Receptor by Van Raemdonck, Katrien, Umar, Sadiq, Palasiewicz, Karol, Volin, Michael V., Elshabrawy, Hatem A., Romay, Bianca, Tetali, Chandana, Ahmed, Azam, Amin, M. Asif, Zomorrodi, Ryan K., Sweiss, Nadera, Shahrara, Shiva

“…Objective In rheumatoid arthritis (RA), elevated serum interleukin‐34 (IL‐34) levels are linked with increased disease severity. IL‐34 binds to 2 receptors,…”
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IL-17 Induces Monocyte Migration in Rheumatoid Arthritis by Shahrara, Shiva, Pickens, Sarah R, Dorfleutner, Andrea, Pope, Richard M

“…Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease which is in part mediated by the migration of monocytes from blood to RA synovial tissue,…”
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IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion by Umar, Sadiq, Palasiewicz, Karol, Van Raemdonck, Katrien, Volin, Michael V., Romay, Bianca, Amin, M. Asif, Zomorrodi, Ryan K., Arami, Shiva, Gonzalez, Mark, Rao, Vikram, Zanotti, Brian, Fox, David A., Sweiss, Nadera, Shahrara, Shiva

“…Flares of joint inflammation and resistance to currently available biologic therapeutics in rheumatoid arthritis (RA) patients could reflect activation of…”
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Macrophages are the primary effector cells in IL-7-induced arthritis by Kim, Seung-jae, Chang, Huan J., Volin, Michael V., Umar, Sadiq, Van Raemdonck, Katrien, Chevalier, Aimee, Palasiewicz, Karol, Christman, John W., Volkov, Suncica, Arami, Shiva, Maz, Mehrdad, Mehta, Anjali, Zomorrodi, Ryan K., Fox, David A., Sweiss, Nadera, Shahrara, Shiva

“…Synovial macrophages are crucial in the development of joint inflammation and bone damage; however, the pathways that control macrophage remodeling in…”
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IL-17 Contributes to Angiogenesis in Rheumatoid Arthritis by Pickens, Sarah R, Volin, Michael V, Mandelin, Arthur M., II, Kolls, Jay K, Pope, Richard M, Shahrara, Shiva

“…Angiogenesis is an early and a critical event in the pathogenesis of rheumatoid arthritis (RA). Neovascularization is dependent on endothelial cell activation,…”
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Characterization of CCL19 and CCL21 in rheumatoid arthritis by Pickens, Sarah R., Chamberlain, Nathan D., Volin, Michael V., Pope, Richard M., Mandelin, Arthur M., Shahrara, Shiva

“…Objective To characterize the expression of CCL19 and CCL21 in rheumatoid arthritis (RA) synovial tissue (ST) and to examine their regulation and pathogenetic…”
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IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells by Elshabrawy, Hatem A., Volin, Michael V., Essani, Abdul B., Chen, Zhenlong, McInnes, Iain B., Van Raemdonck, Katrien, Palasiewicz, Karol, Arami, Shiva, Gonzalez, Mark, Ashour, Hossam M., Kim, Seung-jae, Zhou, Guofei, Fox, David A., Shahrara, Shiva

“…IL-11 has been detected in inflamed joints; however, its role in the pathogenesis of arthritis is not yet clear. Studies were conducted to characterize the…”
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IL-17-Mediated Monocyte Migration Occurs Partially through CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Induction by Shahrara, Shiva, Pickens, Sarah R, Mandelin, Arthur M., II, Karpus, William J, Huang, Qiquan, Kolls, Jay K, Pope, Richard M

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease that is mediated, in part, by proinflammatory factors produced by RA synovial tissue (ST)…”
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The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis by Chen, Zhenlong, Kim, Seung-jae, Chamberlain, Nathan D, Pickens, Sarah R, Volin, Michael V, Volkov, Suncica, Arami, Shiva, Christman, John W, Prabhakar, Bellur S, Swedler, William, Mehta, Anjali, Sweiss, Nadera, Shahrara, Shiva

“…Although the role of IL-7 and IL-7R has been implicated in the pathogenesis of rheumatoid arthritis (RA), the majority of the studies have focused on the…”
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Local expression of interleukin‐27 ameliorates collagen‐induced arthritis by Pickens, Sarah R., Chamberlain, Nathan D., Volin, Michael V., Mandelin, Arthur M., Agrawal, Hemant, Matsui, Masanori, Yoshimoto, Takayuki, Shahrara, Shiva

“…Objective To determine the mechanism of action of interleukin‐27 (IL‐27) against rheumatoid arthritis (RA). Methods Adenovirus containing IL‐27 transcript was…”
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Role of the CCL21 and CCR7 pathways in rheumatoid arthritis angiogenesis by Pickens, Sarah R., Chamberlain, Nathan D., Volin, Michael V., Pope, Richard M., Talarico, Nicholas E., Mandelin II, Arthur M., Shahrara, Shiva

“…Objective To determine the role of CCL21 and its receptor CCR7 in the pathogenesis of rheumatoid arthritis (RA). Methods Histologic studies were performed to…”
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Angiogenesis in Rheumatoid Arthritis Is Fostered Directly by Toll‐like Receptor 5 Ligation and Indirectly Through Interleukin‐17 Induction by Kim, Seung‐jae, Chen, Zhenlong, Chamberlain, Nathan D., Volin, Michael V., Swedler, William, Volkov, Suncica, Sweiss, Nadera, Shahrara, Shiva

“…Objective To examine the impact of Toll‐like receptor 5 (TLR‐5) on endothelial cell function in rheumatoid arthritis (RA) and vascularization in…”
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Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing by Wu, Minghua, Melichian, Denisa S, de la Garza, Mauricio, Gruner, Katherine, Bhattacharyya, Swati, Barr, Luke, Nair, Aisha, Shahrara, Shiva, Sporn, Peter H.S, Mustoe, Thomas A, Tourtellotte, Warren G, Varga, John

“…The early growth response gene (Egr-1) codes for a zinc finger transcription factor that has important roles in the regulation of cell growth, differentiation,…”
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Inhibition of Monocyte Chemoattractant Protein-1 Ameliorates Rat Adjuvant-Induced Arthritis by Shahrara, Shiva, Proudfoot, Amanda E. I, Park, Christy C, Volin, Michael V, Haines, G. Kenneth, Woods, James M, Aikens, Christopher H, Handel, Tracy M, Pope, Richard M

“…Chemokines, including RANTES/CCL5 and MCP-1/CCL2, are highly expressed in the joints of patients with rheumatoid arthritis, and they promote leukocyte…”
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Adalimumab in the treatment of cardiac sarcoidosis: Single center case series and narrative literature review by Sweis, Jaleel Jerry G., Sweis, Nabil William G., Ascoli, Christian, Levin, Benjamin, Avitall, Boaz, Rubinstein, Israel, Kondos, George, Culver, Daniel A., Judson, Marc, Baughman, Robert, Darbar, Dawood, Drake, Wonder, Shahrara, Shiva, Cooper, Leslie T., Sweiss, Nadera J.

“…Tumor necrosis factor (TNF) inhibitors have been used in the treatment of cardiac sarcoidosis, infliximab being the most commonly used. We have previously…”
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Anti-CXCL5 therapy ameliorates IL-17-induced arthritis by decreasing joint vascularization by Pickens, Sarah R., Chamberlain, Nathan D., Volin, Michael V., Gonzalez, Mark, Pope, Richard M., Mandelin, Arthur M., Kolls, Jay K., Shahrara, Shiva

“…IL-17-induced joint inflammation is associated with increased angiogenesis. However, the mechanism by which IL-17 mediates angiogenesis is undefined…”
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