Search Results - "Shahmoradian, Sarah H."

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease by Zhao, Xiaobei, Chen, Xu-Qiao, Han, Eugene, Hu, Yue, Paik, Paul, Ding, Zhiyong, Overman, Julia, Lau, Alice L., Shahmoradian, Sarah H., Chiu, Wah, Thompson, Leslie M., Wu, Chengbiao, Mobley, William C.

“…Corticostriatal atrophy is a cardinal manifestation of Huntington’s disease (HD). However, the mechanism(s) by which mutant huntingtin (mHTT) protein…”
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Cryo-EM structure of Alzheimer’s disease tau filaments with PET ligand MK-6240 by Kunach, Peter, Vaquer-Alicea, Jaime, Smith, Matthew S., Monistrol, Jim, Hopewell, Robert, Moquin, Luc, Therriault, Joseph, Tissot, Cecile, Rahmouni, Nesrine, Massarweh, Gassan, Soucy, Jean-Paul, Guiot, Marie-Christine, Shoichet, Brian K., Rosa-Neto, Pedro, Diamond, Marc I., Shahmoradian, Sarah H.

“…Positron Emission Tomography (PET) ligands have advanced Alzheimer’s disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identify AD…”
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A Compartmentalized Neuronal Cell-Culture Platform Compatible With Cryo-Fixation by High-Pressure Freezing for Ultrastructural Imaging by Tran, Hung Tri, Lucas, Miriam S, Ishikawa, Takashi, Shahmoradian, Sarah H, Padeste, Celestino

“…The human brain contains a wide array of billions of neurons and interconnections, which are often simplified for analysis using compartmentalized microfluidic…”
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Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract by Shen, Koning, Calamini, Barbara, Fauerbach, Jonathan A, Ma, Boxue, Shahmoradian, Sarah H, Serrano Lachapel, Ivana L, Chiu, Wah, Lo, Donald C, Frydman, Judith

“…Many neurodegenerative diseases are linked to amyloid aggregation. In Huntington's disease (HD), neurotoxicity correlates with an increased aggregation…”
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Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates by Galaz-Montoya, Jesús G., Shahmoradian, Sarah H., Shen, Koning, Frydman, Judith, Chiu, Wah

“…Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT)…”
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Supramolecular Non-Amyloid Intermediates in the Early Stages of α-Synuclein Aggregation by Fauerbach, Jonathan A., Yushchenko, Dmytro A., Shahmoradian, Sarah H., Chiu, Wah, Jovin, Thomas M., Jares-Erijman, Elizabeth A.

“…The aggregation of α-synuclein is associated with progression of Parkinson's disease. We have identified submicrometer supramolecular structures that mediate…”
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TRiC's tricks inhibit huntingtin aggregation by Shahmoradian, Sarah H, Galaz-Montoya, Jesus G, Schmid, Michael F, Cong, Yao, Ma, Boxue, Spiess, Christoph, Frydman, Judith, Ludtke, Steven J, Chiu, Wah

“…In Huntington's disease, a mutated version of the huntingtin protein leads to cell death. Mutant huntingtin is known to aggregate, a process that can be…”
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Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson's Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography by Tran, Hung Tri, Tsai, Esther H R, Lewis, Amanda J, Moors, Tim, Bol, J G J M, Rostami, Iman, Diaz, Ana, Jonker, Allert J, Guizar-Sicairos, Manuel, Raabe, Joerg, Stahlberg, Henning, van de Berg, Wilma D J, Holler, Mirko, Shahmoradian, Sarah H

“…Gaining insight to pathologically relevant processes in continuous volumes of unstained brain tissue is important for a better understanding of neurological…”
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Breakthroughs in medicine and bioimaging with up-conversion nanoparticles by Rostami, Iman, Rezvani Alanagh, Hamideh, Hu, Zhiyuan, Shahmoradian, Sarah H

“…Nanomedicine is a medical application of biochemistry incorporated with materials chemistry at the scale of nanometer for the purpose of diagnosis, prevention,…”
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TorsinA is essential for neuronal nuclear pore complex localization and maturation by Kim, Sumin, Phan, Sébastien, Tran, Hung Tri, Shaw, Thomas R., Shahmoradian, Sarah H., Ellisman, Mark H., Veatch, Sarah L., Barmada, Sami J., Pappas, Samuel S., Dauer, William T.

“…As lifelong interphase cells, neurons face an array of unique challenges. A key challenge is regulating nuclear pore complex (NPC) biogenesis and localization,…”
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Imaging of post-mortem human brain tissue using electron and X-ray microscopy by Lewis, Amanda J, Genoud, Christel, Pont, Mélissa, van de Berg, Wilma DJ, Frank, Stephan, Stahlberg, Henning, Shahmoradian, Sarah H, Al-Amoudi, Ashraf

“…•Ultrastructural imaging of PMHB provides novel insights into neurodegenerative disease.•Electron microscopy is a powerful tool for detailed (3D) structural…”
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Docking for Molecules That Bind in a Symmetric Stack with SymDOCK by Smith, Matthew S., Knight, Ian S., Kormos, Rian C., Pepe, Joseph G., Kunach, Peter, Diamond, Marc I., Shahmoradian, Sarah H., Irwin, John J., DeGrado, William F., Shoichet, Brian K.

“…Discovering ligands for amyloid fibrils, such as those formed by the tau protein, is an area of great current interest. In recent structures, ligands bind in…”
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A lathe system for micrometre‐sized cylindrical sample preparation at room and cryogenic temperatures by Holler, Mirko, Ihli, Johannes, Tsai, Esther H. R., Nudelman, Fabio, Verezhak, Mariana, van de Berg, Wilma D. J., Shahmoradian, Sarah H.

“…A simple two‐spindle based lathe system for the preparation of cylindrical samples intended for X‐ray tomography is presented. The setup can operate at room…”
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Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles by Navarro, Paula P., Genoud, Christel, Castaño-Díez, Daniel, Graff-Meyer, Alexandra, Lewis, Amanda J., de Gier, Yvonne, Lauer, Matthias E., Britschgi, Markus, Bohrmann, Bernd, Frank, Stephan, Hench, Jürgen, Schweighauser, Gabriel, Rozemuller, Annemieke J. M., van de Berg, Wilma D. J., Stahlberg, Henning, Shahmoradian, Sarah H.

“…Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward,…”
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Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography by Shahmoradian, Sarah H, Galiano, Mauricio R, Wu, Chengbiao, Chen, Shurui, Rasband, Matthew N, Mobley, William C, Chiu, Wah

“…Neurites, both dendrites and axons, are neuronal cellular processes that enable the conduction of electrical impulses between neurons. Defining the structure…”
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Early segregation of layered projections from the lateral superior olivary nucleus to the central nucleus of the inferior colliculus in the neonatal cat by Gabriele, Mark L, Shahmoradian, Sarah H, French, Christopher C, Henkel, Craig K, McHaffie, John G

“…Abstract The central nucleus of the inferior colliculus (IC) is a laminated structure that receives multiple converging afferent projections. These projections…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Supramolecular Non-Amyloid Intermediates in the Early Stages of [alpha]-Synuclein Aggregation by Fauerbach, Jonathan A, Yushchenko, Dmytro A, Shahmoradian, Sarah H, Chiu, Wah, Jovin, Thomas M, Jares-Erijman, Elizabeth A

“…The aggregation of α-synuclein is associated with progression of Parkinson's disease. We have identified submicrometer supramolecular structures that mediate…”
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Preparation of Primary Neurons for Visualizing Neurites in a Frozen-hydrated State Using Cryo-Electron Tomography by Shahmoradian, Sarah H., Galiano, Mauricio R., Wu, Chengbiao, Chen, Shurui, Rasband, Matthew N., Mobley, William C., Chiu, Wah

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Early segregation of layered projections from the lateral superior olivary nucleusto the central nucleus of the inferior colliculus in the neonatal cat by Gabriele, Mark L., Shahmoradian, Sarah H., French, Christopher C., Henkel, Craig K.we, McHaffie, John G.

“…The central nucleus of the inferior colliculus (IC) is a laminated structure that receives multiple converging afferent projections. These projections…”
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