Effects of Space Mission Factors on the Morphology and Function of Endothelial Cells

Effects of Space Mission Factors on the Morphology and Function of Endothelial Cells

The structure and functions of endothelial cells after space mission were studied by electron and laser confocal microscopy, image analysis, and MTT test. The endothelial cells changed signifi cantly (proliferative activity, size, contours, shape, distribution of mitochondria and microtubules) in co...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 154; no. 6; pp. 796 - 801
Main Authors: Kapitonova, M. Yu, Kuznetsov, S. L., Froemming, G. R. A., Muid, S., Nor-Ashikin, M. N. K., Otman, S., Shahir, A. R. M., Nawawi, H.
Format: Journal Article
Language:English
Published: Boston Springer US 01-04-2013
Springer
Springer Nature B.V
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Membrane - ultrastructure
Cell Proliferation
Cell Shape
Cell Size
Cells
Cells, Cultured
Endothelium
Human Umbilical Vein Endothelial Cells - physiology
Human Umbilical Vein Endothelial Cells - ultrastructure
Internal Medicine
Laboratory Medicine
Mitochondria - metabolism
Mitochondrial DNA
Pathology
Space Flight
Tubulin - metabolism
Weightlessness
scanning electron microscopy
endothelium
fl uorescent microscopy
morphometry
zero gravity
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Summary:The structure and functions of endothelial cells after space mission were studied by electron and laser confocal microscopy, image analysis, and MTT test. The endothelial cells changed signifi cantly (proliferative activity, size, contours, shape, distribution of mitochondria and microtubules) in comparison with controls on the Earth. These changes indicated injuries in the cytoskeleton and impairment of the barrier function of the cells, which presumably contributed to the development of endothelial dysfunction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2059-7