Cytodiagnosis of nipple discharge: A study of 602 samples from 484 cases

Cytodiagnosis of nipple discharge: A study of 602 samples from 484 cases

To find out the gross and microscopic differentiating features between nipple discharges (ND) due to various breast lesions, smears of 602 ND samples from 484 cases were reviewed by one of the investigators (D.K.D.). The reviewed cytodiagnoses were as follows: benign nipple discharge (59.1%), inflam...

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Bibliographic Details
Published in:Diagnostic cytopathology Vol. 25; no. 1; pp. 25 - 37
Main Authors: Das, Dilip K., Al-Ayadhy, Bushra, Ajrawi, M. Tareq G., Shaheen, Azza A., Sheikh, Zaffar A., Malik, Mrinmay, Pathan, Shahed K., Ebrahim, Bahiyah, Francis, Issam M., Satar, Sitara A., Abdulla, Mohamed A., Luthra, Usha K., Junaid, Thamradeen A.
Format: Journal Article
Language:English
Published: New York John Wiley & Sons, Inc 01-07-2001
Wiley-Liss
Subjects:
Biological and medical sciences
breast
Breast Diseases - diagnosis
Breast Diseases - pathology
Cytodiagnosis - methods
Cytodiagnosis - trends
cytology
Diagnosis, Differential
Female
fine-needle aspiration
Gynecology. Andrology. Obstetrics
Humans
Male
Mammary gland diseases
Medical sciences
nipple discharge
Nipples - immunology
Nipples - pathology
Tumors
Human
Mammary gland diseases
Pathology
Nipple discharge
Smear
Cytopathology
Female
Inflammation
Diagnosis
Mammary gland
Benign neoplasm
Malignant tumor
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Summary:To find out the gross and microscopic differentiating features between nipple discharges (ND) due to various breast lesions, smears of 602 ND samples from 484 cases were reviewed by one of the investigators (D.K.D.). The reviewed cytodiagnoses were as follows: benign nipple discharge (59.1%), inflammatory ND (6.5%), ?papillary lesions (2.5%), papillary lesions (20.6%), papillary lesions with atypia (3.8%), duct cells with atypia (0.2%), suspicious for malignancy (0.5%), malignant ND (1.2%), and inadequate (5.6%). Following review, samples with epithelial abnormalities (?papillary lesion, papillary lesion with and without atypia, duct cells with atypia, suspicious for malignancy, and malignancy) increased from 16.6% to 30.4% of adequate samples (P < 0.0001). 37.9% unilateral ND samples showed epithelial abnormalities, as opposed to 18.9% of bilateral ND samples (P < 0.0001). Bloodstained ND showed epithelial abnormalities in 41.5% samples, as compared to 22.1% of ND with other specified gross characteristics (P<0.0001). The samples with epithelial abnormalities differed significantly from benign and inflammatory ND in respect of frequency of benign duct cells, duct cells with atypia, papillary clusters with or without atypia, malignant cells, columnar cells, red blood cells, inflammatory cells, and background lipid vacuoles (P < 0.01 to < 0.0001). The ND samples with suspicious and malignant cytology, besides the presence of malignant cells (P < 0.0001), differed significantly from rest of the lesions in respect of foam cells (P < 0.0001), red blood cells (P<0.01), and inflammatory cells (P < 0.05). When compared with histopathological diagnosis in 20 cases, the benign or malignant nature of the lesion was correctly identified in ND in 80% cases. The ND cytologies in 7 histologically proved malignant cases were malignancy (3 cases), suspicious for malignancy (1 case), papillary lesion with atypia (1 case), papillary lesion (1 case), and benign ND (1 case). Diagn. Cytopathol. 25:25–37, 2001. © 2001 Wiley‐Liss, Inc.
Bibliography:istex:97332BA3C8A15D034B9A684062DFF20F2E5F83C2
ark:/67375/WNG-3K6T7QTN-R
ArticleID:DC1098
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.1098