Search Results - "Shah, Vandna"

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response by Butler, Laura R, Densham, Ruth M, Jia, Junying, Garvin, Alexander J, Stone, Helen R, Shah, Vandna, Weekes, Daniel, Festy, Frederic, Beesley, James, Morris, Joanna R

“…The regulation of Ubiquitin (Ub) conjugates generated by the complex network of proteins that promote the mammalian DNA double‐strand break (DSB) response is…”
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Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years by Petridis, Christos, Arora, Iteeka, Shah, Vandna, Megalios, Anargyros, Moss, Charlotte, Mera, Anca, Clifford, Angela, Gillett, Cheryl, Pinder, Sarah E, Tomlinson, Ian, Roylance, Rebecca, Simpson, Michael A, Sawyer, Elinor J

“…Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal breast cancer, and approximately 20% of screen-detected tumours are pure DCIS…”
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Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial by Tutt, Andrew, Tovey, Holly, Cheang, Maggie Chon U., Kernaghan, Sarah, Kilburn, Lucy, Gazinska, Patrycja, Owen, Julie, Abraham, Jacinta, Barrett, Sophie, Barrett-Lee, Peter, Brown, Robert, Chan, Stephen, Dowsett, Mitchell, Flanagan, James M, Fox, Lisa, Grigoriadis, Anita, Gutin, Alexander, Harper-Wynne, Catherine, Hatton, Matthew Q., Hoadley, Katherine A., Parikh, Jyoti, Parker, Peter, Perou, Charles M., Roylance, Rebecca, Shah, Vandna, Shaw, Adam, Smith, Ian E., Timms, Kirsten M., Wardley, Andrew M., Wilson, Gregory, Gillett, Cheryl, Lanchbury, Jerry S., Ashworth, Alan, Rahman, Nazneen, Harries, Mark, Ellis, Paul, Pinder, Sarah E., Bliss, Judith M.

“…Germline mutations in BRCA1/2 predispose individuals to breast cancer (termed germline-mutated BRCA1/2 breast cancer, gBRCA-BC) by impairing homologous…”
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SOX11 promotes invasive growth and ductal carcinoma in situ progression by Oliemuller, Erik, Kogata, Naoko, Bland, Philip, Kriplani, Divya, Daley, Frances, Haider, Syed, Shah, Vandna, Sawyer, Elinor J, Howard, Beatrice A

“…Here, we show that SOX11, an embryonic mammary marker that is normally silent in postnatal breast cells, is expressed in many oestrogen receptor‐negative…”
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Frequency of Pathogenic Germline Variants in CDH1, BRCA2, CHEK2, PALB2, BRCA1 , and TP53 in Sporadic Lobular Breast Cancer by Petridis, Christos, Arora, Iteeka, Shah, Vandna, Moss, Charlotte L, Mera, Anca, Clifford, Angela, Gillett, Cheryl, Pinder, Sarah E, Tomlinson, Ian, Roylance, Rebecca, Simpson, Michael A, Sawyer, Elinor J

“…Invasive lobular breast cancer (ILC) accounts for approximately 15% of invasive breast carcinomas and is commonly associated with lobular carcinoma (LCIS)…”
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Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer by Treekitkarnmongkol, Warapen, Shah, Vandna, Kai, Kazuharu, Katayama, Hiroshi, Wong, Justin, Ladha, Farah A., Nguyen, Tristian, Menegaz, Brian, Lu, Wei, Yang, Fei, Mino, Barbara, Tang, Ximing, Gagea, Mihai, Batra, Harsh, Raso, Maria Gabriela, Wistuba, Ignacio I., Krishnamurthy, Savitri, Pinder, Sarah E., Sawyer, Elinor J., Thompson, Alastair M., Sen, Subrata

“…Background Risk of recurrence and progression of ductal carcinoma in situ (DCIS) to invasive cancer remains uncertain, emphasizing the need for developing…”
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MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours by Garcia-Dios, Diego A, Levi, Dina, Shah, Vandna, Gillett, Cheryl, Simpson, Michael A, Hanby, Andrew, Tomlinson, Ian, Sawyer, Elinor J

“…Background: MED12 and TERT promoter mutations have been shown to be the most common somatic mutations in phyllodes tumours (PTs). The aims of this study were…”
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Abstract PS16-03: Clonal relatedness of LCIS with synchronous and asynchronous invasive disease by Sawyer, Elinor, Sborchia, Mateja, Megalios, Anargyros, Shah, Vandna, Nowinski, Salpie, Vassart, Cloe, Grigoriadis, Anita, Thompson, Alastair, Tomlinson, Ian, Roylance, Rebecca, Pinder, Sarah

“…Abstract Background: Lobular carcinoma in situ (LCIS) is typically clinically undetectable but is being increasingly diagnosed as a result of breast screening…”
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Abstract PD13-03: Genomic profiling of breast cancer leptomeningeal metastasis (BCLM) reveals a divergent evolution and therapeutic targets by Fitzpatrick, Amanda, Iravani, Marjan, Mills, Adam, Knight, Eleanor, Alaguthurai, Thanussuyah, Shah, Vandna, Okines, Alicia, Turner, Nick, Harries, Mark, Haider, Syed, Tutt, Andrew, Isacke, Clare

“…Abstract Background: Leptomeningeal metastasis remains a devastating development in breast cancer, with a median survival of 3-4 months, no widely accepted…”
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Abstract A016: Identification of methylated regions in ductal carcinoma in situ and association with disease progression by Shah, Vandna, Roman-Escorza, Maria, Clements, Karen Clements, Mulder, Lennart, Lips, Esther H., Wesseling, Jelle, Pinder, Sarah, Thompson, Alastair M., Sawyer, Elinor J.

“…Abstract Background: The advent of breast screening has led to a 4-fold increase in the diagnosis of ductal carcinoma in situ (DCIS). Studies following the…”
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Archival single-cell genomics reveals persistent subclones during DCIS progression by Wang, Kaile, Kumar, Tapsi, Wang, Junke, Minussi, Darlan Conterno, Sei, Emi, Li, Jianzhuo, Tran, Tuan M., Thennavan, Aatish, Hu, Min, Casasent, Anna K., Xiao, Zhenna, Bai, Shanshan, Yang, Lei, King, Lorraine M., Shah, Vandna, Kristel, Petra, van der Borden, Carolien L., Marks, Jeffrey R., Zhao, Yuehui, Zurita, Amado J., Aparicio, Ana, Chapin, Brian, Ye, Jie, Zhang, Jianjun, Gibbons, Don L., Sawyer, Ellinor, Thompson, Alastair M., Futreal, Andrew, Hwang, E. Shelley, Wesseling, Jelle, Lips, Esther H., Navin, Nicholas E.

“…Ductal carcinoma in situ (DCIS) is a common precursor of invasive breast cancer. Our understanding of its genomic progression to recurrent disease remains…”
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Abstract P4-07-04: Genomic analysis of paired DCIS and subsequent recurrence to assess clonal relatedness in screen detected DCIS by Shah, Vandna, Megalios, Anargyros, Shami, Rana, Sridharan, Mathini, de Souza, Carolina Salinas, Kumar, Tapsi, Clements, Karen, Futreal, Andrew, Pinder, Sarah, Thompson, Alastair, Sawyer, Elinor Jane

“…Abstract In order to understand the clonal relatedness of DCIS and subsequent recurrence, 40 patients with primary DCIS that developed a subsequent ipsilateral…”
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Abstract P4-06-05: Heterogeneity of DCIS does not appear to be a biomarker for development of subsequent invasive cancer by Megalios, Anargyros, Shah, Vandna, Shami, Rana, Nowinski, Salpie, Quist, Jelmar, Sridharan, Mathini, de Souza, Carolina Salinas, Clements, Karen, Grigoriadis, Anita, Pinder, Sarah, Thompson, Alastair, Sawyer, Elinor

“…Abstract Genomic instability is a key feature of carcinogenesis, giving rise to tumour promoting aberrations. The inherent unpredictability of these processes…”
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Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers by Watkins, Johnathan, Weekes, Daniel, Shah, Vandna, Gazinska, Patrycja, Joshi, Shalaka, Sidhu, Bhavna, Gillett, Cheryl, Pinder, Sarah, Vanoli, Fabio, Jasin, Maria, Mayrhofer, Markus, Isaksson, Anders, Cheang, Maggie C U, Mirza, Hasan, Frankum, Jessica, Lord, Christopher J, Ashworth, Alan, Vinayak, Shaveta, Ford, James M, Telli, Melinda L, Grigoriadis, Anita, Tutt, Andrew N J

“…Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair…”
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Abstract A017: Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer by Treekitkarnmongkol, Warapen, Shah, Vandna, Kai, Kazuharu, Katayama, Hiroshi, Wong, Justin W., Ladha, Farah A, Menegaz, Brian, Pinder, Sarah E., Lu, Wei, Yang, Fei, Tang, Ximing, Krishnamurthy, Savitri, Wistuba, Ignacio I., Sawyer, Elinor J., Thompson, Alastair M., Sen, Subrata

“…Abstract Background: Screening mammography has dramatically increased incidental detection of Ductal Carcinoma in situ (DCIS), a non-obligate precursor of…”
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Abstract P1-22-05: Identifying predictors of invasive recurrence based on molecular profiles of DCIS lesions by Bismeijer, Tycho, Ahmed, Ahmed A, Sheinman, Michael, Roman-Escorza, Maria, Shah, Vandna, Marks, Jeffrey R, King, Lorraine M, Megalios, Anargyros, Visser, Lindy L, Hoogstraat, Marlous, Davies, Helen R, Kumar, Tapsi, Collyar, Deborah, Stobart, Hilary, Navin, Nicholas N, Futreal, Andrew, Nik-Zainal, Serena, Hwang, Shelley, Lips, Esther H, Thompson, Alastair, Wessels, Lodewyk FA, Sawyer, Elinor J, Wesseling, Jelle

“…Abstract Introduction Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Patients with DCIS are routinely treated by…”
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Abstract 3363: PUM3 is a triple-negative breast cancer dependency gene that functions in replication fork restart and repair by Weekes, Daniel, Noel, Elodie, Walker, Callum, Balan, Nick, Shah, Vandna, Sidhu, Bhavna, Pardix, Anna, Pettitt, Stephen, Lord, Christopher J., Grigoriadis, Anita, Andrew, Tutt N.

“…Abstract Triple-Negative Breast Cancers (TNBC) are characterized by high levels of structural chromosome alterations and harbor mutational scars of defects in…”
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Abstract PR002: Genomic predictor can discriminate between high- and low-risk DCIS by Escorza, Maria Roman, Sheinman, Michael, Bismeijer, Tycho, Ahmed, Ahmed A., Shah, Vandna, Marks, Jeffrey R., King, Lorraine M., Megalios, Anargyros, Visser, Lindy L., Hoogstrat, Marlous, Davies, Helen R., Kumar, Tapsi, Collyar, Deborah, Stobart, Hilary, Pinder, Sarah, Navin, Nicholas N., Futreal, Andrew, Nik-Zainal, Serena, Hwang, E. Shelley, Lips, Esther H., Thompson, Alastair, Wessels, Lodewyk F.A., Wesseling, Jelle, Sawyer, Elinor J.

“…Abstract Introduction: Ductal carcinoma in situ (DCIS) is considered a non-obligate precursor of invasive ductal carcinoma. With the aim of preventing a…”
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PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression by Shah, Vandna, Nowinski, Salpie, Levi, Dina, Shinomiya, Irek, Kebaier Ep Chaabouni, Narda, Gillett, Cheryl, Grigoriadis, Anita, Graham, Trevor A, Roylance, Rebecca, Simpson, Michael A, Pinder, Sarah E, Sawyer, Elinor J

“…Lobular carcinoma in situ (LCIS) is a non-invasive breast lesion that is typically found incidentally on biopsy and is often associated with invasive lobular…”
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Abstract 125: Archival single cell sequencing reveals persistent subclones over years to decades of DCIS progression by Wang, Kaile, Kumar, Tapsi, wang, Junke, Minussi, Darlan, Sei, Emi, li, Jianzhuo, Tran, Tuan, Thennavan, Aatish, Hu, Min, Casasent, Anna, Xiao, Zhenna, Bai, Shanshan, Zhao, Yuehui, Zurita, Amado, Aparicio, Ana, Chapin, Brian, ye, Jie, Zhang, Jianjun, Gibbons, Don, Futreal, Andrew, King, Lorraine, Marks, Jeffrey, Hwang, E. Shelley, Shah, Vandna, Sawyer, Ellinor, Kristel, Petra, Wesseling, Jelle, Lips, Esther H., Navin, Nicholas

“…Abstract Ductal carcinoma in situ (DCIS) is a common precursor of invasive breast cancer (IBC), yet the genomic progression to recurrent disease remains poorly…”
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