Search Results - "Shah, Shailesh R"

Anticancer, antimicrobial activities of quinoline based hydrazone analogues: Synthesis, characterization and molecular docking by Katariya, Kanubhai D, Shah, Shailesh R., Reddy, Dushyanth

“…[Display omitted] •New quinolyl hydrazones, 18a-p have been prepared and characterized.•Among all compound, 18j demonstrated highest (GI50 = 0.33 μM)…”
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1,3‐Oxazole‐isoniazid hybrids: Synthesis, antitubercular activity, and their docking studies by Shah, Shailesh R., Katariya, Kanubhai D.

“…A series of novel N′‐([2‐aryl‐5‐methyl‐1,3‐oxazole‐4‐yl]methylene)isonicotino/nicotino hydrazides 10a‐l were prepared by the condensation reaction of…”
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Discovery of Orally Active, Potent, and Selective Benzotriazole-Based PTP1B Inhibitors by Patel, Dipam, Jain, Mukul, Shah, Shailesh R., Bahekar, Rajesh, Jadav, Pradip, Darji, Brijesh, Siriki, Yernaidu, Bandyopadhyay, Debdutta, Joharapurkar, Amit, Kshirsagar, Samadhan, Patel, Harilal, Shaikh, Mubeen, Sairam, Kalapatapu V. V. M., Patel, Pankaj

“…A two‐hand grasp on one enzyme: A novel series of dual‐site benzotriazole derivatives are reported as potent PTP1B inhibitors. Some of the test compounds…”
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Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes by Pola, Suresh, Shah, Shailesh R., Pingali, Harikishore, Zaware, Pandurang, Thube, Baban, Makadia, Pankaj, Patel, Hoshang, Bandyopadhyay, Debdutta, Rath, Akshyaya, Giri, Suresh, Patel, Jitendra H., Ranvir, R.K., Sundar, S.R., Patel, Harilal, Kumar, Jeevan, Jain, Mukul R.

“…[Display omitted] The ever-growing prevalence of Type-2 diabetes in the world has an urgent need for multiple orally effective agents that can regulate glucose…”
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Peptidomimetics as potent and selective PTP1B inhibitors by Patel, Dipam, Jain, Mukul, Shah, Shailesh R, Bahekar, Rajesh, Jadav, Pradip, Shah, Kiran, Joharapurkar, Amit, Shaikh, Mubeen, Sairam, Kalapatapu V V M

“…A series of peptidomimetic containing bidentate pTyr mimetics (9a-w) are reported as potent and selective PTP1B inhibitors. Compounds (9p and 9q) showed…”
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In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma by Sheth, Gaurav, Shah, Shailesh R., Sengupta, Prabal, Jarag, Tushar, Chimanwala, Sabbirhusen, Sairam, Kalapatapu V. V. M., Jain, Vaibhav, Talwar, Rashmi, Dhanave, Avinash, Raviya, Mehul, Menon, Soumya, Trivedi, Shivangi, Chitturi, Trinadha Rao

“…The genome of pancreatic ductal adenocarcinoma (PDAC) is associated with frequent deletion of the tumor suppressor gene SMAD family member 4 (SMAD4) with…”
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Practical and Efficient Synthesis of 2‑Thio-imidazole DerivativeZY12201: A Potent TGR5 Agonist by Joshi, Vivek M, Sojitra, Chandrakant, Sasane, Santosh, Shukla, Mrigendra, Chauhan, Rakesh, Chaubey, Vipin, Jain, Sarika, Shah, Kalpesh, Mande, Hemant, Soman, Shubhangi, Pamidimukkala, Padmaja Sudhakar, Shah, Shailesh R, Pandey, Bipin, Singh, Kumar K, Agarwal, Sameer

“…Early scalable process development for the synthesis of ZY12201, a novel TGR5 receptor agonist, as a potential clinical candidate is described. A practical,…”
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Design, synthesis and biological evaluation of novel aminomethyl-piperidones based DPP-IV inhibitors by Jadav, Pradip, Bahekar, Rajesh, Shah, Shailesh R, Patel, Dipam, Joharapurkar, Amit, Jain, Mukul, Sairam, Kalapatapu V V M, Singh, Praveen Kumar

“…A series of novel aminomethyl-piperidones were designed and evaluated as potential DPP-IV inhibitors. Optimized analogue 12v…”
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Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors by Patel, Dipam, Jain, Mukul, Shah, Shailesh R., Bahekar, Rajesh, Jadav, Pradip, Joharapurkar, Amit, Dhanesha, Nirav, Shaikh, Mubeen, Sairam, Kalapatapu V.V.M., Kapadnis, Prashant

“…A novel series of DFMP/DFMS/ISD containing triaryl-sulfonamide derivatives (5a–r) are reported as potent PTP1B inhibitors. Some of the test compounds exhibits…”
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Long-acting peptidomimetics based DPP-IV inhibitors by Jadav, Pradip, Bahekar, Rajesh, Shah, Shailesh R., Patel, Dipam, Joharapurkar, Amit, Kshirsagar, Samadhan, Jain, Mukul, Shaikh, Mubeen, Sairam, Kalapatapu V.V.M.

“…Peptidomimetic based cyanopyrrolidine derivatives are reported as potent and selective DPP-IV inhibitors. The lead compound (16c) showed long acting…”
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Thermal Rearrangement of Azido Ketones into Oxazoles via Azirines: One-Pot, Metal-Free Heteroannulation to Functionalized 1,3-Oxazoles by Shah, Shailesh R., Navathe, Sudhanva S., Dikundwar, Amol G., Guru Row, Tayur N., Vasella, Andrea T.

“…α‐Azidoacetophenones were converted into 2‐aryl‐1,3‐oxazole‐4‐carbaldehydes through rearrangement of the carbon framework upon exposure to DMF/POCl3. The…”
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Room-Temperature Ionic Liquid-DMSO Promoted and Improved One-Pot Synthesis of 5,6-Diaryl-1,2,4-triazines by Tamboli, Riyaj S., Giridhar, Rajani, Mande, Hemant M., Shah, Shailesh R., Yadav, Mange Ram

“…An improved and rapid one-pot synthesis of 5,6-diarylsubstituted-1,2,4-triazines in a mixture of room-temperature ionic liquid 1,3-dibutylimidazolium bromide…”
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Effect of structurally constrained oxime–ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists by Makadia, Pankaj, Shah, Shailesh R., Pingali, Harikishore, Zaware, Pandurang, Patel, Darshit, Pola, Suresh, Thube, Baban, Priyadarshini, Priyanka, Suthar, Dinesh, Shah, Maanan, Giri, Suresh, Trivedi, Chitrang, Jain, Mukul, Patel, Pankaj, Bahekar, Rajesh

“…Effect of incorporation of structurally constrained oxime–ether linker in the chemotype of a PPARδ agonist (GW-501516) towards the modulation of PPAR subtype…”
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Mechanistic Pathway for the Formation of Radial Polystyrenes Using Diacyl Chloride by Kumar, Santosh, Shah, Priyank N, Ahn, Seonyoung, Hwang, Woon Sung, Sung, Ik Kyung, Shah, Shailesh R, Murthy, C. N, Chang, Taihyun, Lee, Jae-Suk

“…An efficient and useful synthetic route for the synthesis of linear and star polystyrenes (PS) is described, employing living anionic polymerization to link…”
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Modulation of PPAR subtype selectivity. Part 2: Transforming PPAR α/ γ dual agonist into α selective PPAR agonist through bioisosteric modification by Zaware, Pandurang, Shah, Shailesh R., Pingali, Harikishore, Makadia, Pankaj, Thube, Baban, Pola, Suresh, Patel, Darshit, Priyadarshini, Priyanka, Suthar, Dinesh, Shah, Maanan, Jamili, Jeevankumar, Sairam, Kalapatapu V.V.M., Giri, Suresh, Patel, Lala, Patel, Harilal, Sudani, Hareshkumar, Patel, Hiren, Jain, Mukul, Patel, Pankaj, Bahekar, Rajesh

“…A novel series of oxime containing benzyl-1,3-dioxane- r-2-carboxylic acid derivatives are reported as selective PPAR α agonists. Some of the test compounds…”
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Synthesis and molecular docking study of new 1,3-oxazole clubbed pyridyl-pyrazolines as anticancer and antimicrobial agents by Katariya, Kanubhai D., Vennapu, Dushyanth R., Shah, Shailesh R.

“…•A series of new 1,3-oxazole clubbed pyridyl-pyrazolines have been synthesized and characterized.•All the new oxazole-pyridyl-pyrazolines have been studied for…”
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Quinoline‐1,3‐Oxazole Hybrids: Syntheses, Anticancer Activity and Molecular Docking Studies by Shah, Shailesh R., Katariya, Kanubhai D., Reddy, Dushyanth

“…In continuation of the synthesis of potent quinoline based anticancer agents, a series of novel quinoline‐1,3‐oxazole hybrids 15 a‐l were synthesized by the…”
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Molecular Container and Metal Ion Sensor Chiral Cavitands by Desai, Arpita S., Rajamannar, Thennati, Shah, Shailesh R.

“…Chiral macrocyclic cavitands prepared by a template free, high dilution methodology have been discovered to function as molecular containers accommodating…”
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Facile one-pot synthesis of linear and radial block copolymers of styrene and isoprene through a novel coupling agent by living anionic polymerization by Kumar, Santosh, Shah, Priyank N, Kang, Beom-Goo, Min, Joon-Keun, Hwang, Woon Sung, Sung, Ik Kyung, Shah, Shailesh R, Murthy, Chivukula N, Ahn, Seonyoung, Chang, Taihyun, Lee, Jae-Suk

“…A new methodology is successfully used for the concurrent synthesis of three different copolymers; diblock, triblock, and three-armed star-block copolymers of…”
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Improved Rapid and Green Synthesis of N‐Aryl Piperazine Hydrochlorides Using Synergistic Coupling of Hydrated Task Specific Ionic Liquid ([BbIm]OH) and Microwave Irradiation by Tamboli, Riyaj S., Shidore, Mahesh M., Dash, Radha Charan, Kanhed, Ashish M., Patel, Nirav R., Shah, Shailesh R., Yadav, Mangeram Ram

“…An improved and rapid green synthesis of N‐alkyl/aryl piperazine hydrochlorides using synergistic coupling of hydrated Task Specific Ionic Liquid ([BbIm]OH)…”
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