Assessing disintegration effectiveness: A thorough evaluation using the SeDeM-ODT expert system for doxylamine succinate orodispersible formulation

The SeDeM-ODT expert system is designed to assess the suitability of the pharmaceutical ingredients for their conversion into an orodispersible formulation by direct compression. The tool can be utilized to select the most appropriate excipients that improve the compressibility and buccodispersibili...

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Bibliographic Details
Published in:	PloS one Vol. 19; no. 9; p. e0310334
Main Authors:	Ahmad, Salman Ashfaq, Hasan, Syed Muhammad Farid, Bafail, Duaa, Shah, Saira Faraz, Imran, Muhammad, Sahar, Tuba, Ishaqui, Azfar Athar
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 17-09-2024
Subjects:	Administration, Oral Analysis Bioavailability Biology and Life Sciences Chemistry, Pharmaceutical - methods Compressibility Compression Compression tests Computer and Information Sciences Disintegration Dosage and administration Doxylamine Doxylamine - administration & dosage Doxylamine - analogs & derivatives Doxylamine - chemistry Drug Compounding - methods Drug dosages Effectiveness Engineering and Technology Excipients Excipients - chemistry Expert systems Formulations Friability Medicine and Health Sciences Methods Parameters Patient compliance Performance evaluation Pharmaceuticals Physical Sciences Powders Rheology Sodium Solubility Tablets - chemistry Water absorption Saudi Arabia United Kingdom China United States > US India
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Summary:	The SeDeM-ODT expert system is designed to assess the suitability of the pharmaceutical ingredients for their conversion into an orodispersible formulation by direct compression. The tool can be utilized to select the most appropriate excipients that improve the compressibility and buccodispersibility of the formulation. This study aimed to utilize the SeDeM-ODT expert system to evaluate the performance of superdisintegrants and select an appropriate superdisntegrant for Doxylamine Succinate orodispersible formulation. The SeDeM-ODT expert system scrutinized the excipients to develop an orodispersible Doxylamine Succinate formulation. Among the 15 parameters of the tool, some of them were determined through experimental work, while the remaining were calculated through the experimental values of other parameters. The central composite design approach was used for formulation development. The prepared powder blends were compressed using the direct compression method and evaluated for different parameters (hardness, thickness, diameter, friability, weight variation, water absorption ratio, wetting time, and disintegration time). The results of the SeDeM-ODT expert system were correlated with the values obtained by the post-compression tests. The Crospovidone formulation (F7) was found to be an optimized formulation as it disintegrated quickly compared with the other formulations containing other superdisintegtrants. The results perfectly endorsed the SeDeM-ODT expert system evaluation, as Crospovidone showed the highest IGCB value of 6.396. The study observed the effectiveness of the expert system in accurately examining the performance of disintegrating agents. The study observed the effectiveness of the expert system in accurately examining the performance of disintegrating agents. The assessment proved Crospovidone to produce quicker disintegration in Doxylamine Succinate orodispersible formulation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0310334