Search Results - "Shah, Sagar R"

Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases by Park, JinSeok, Kim, Deok-Ho, Shah, Sagar R., Kim, Hong-Nam, Kshitiz, Kim, Peter, Quiñones-Hinojosa, Alfredo, Levchenko, Andre

“…Collective cell migration occurs in many patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding…”
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Improving Immunotherapy Through Glycodesign by Buettner, Matthew J, Shah, Sagar R, Saeui, Christopher T, Ariss, Ryan, Yarema, Kevin J

“…Immunotherapy is revolutionizing health care, with the majority of high impact "drugs" approved in the past decade falling into this category of therapy…”
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Verteporfin-Loaded Poly(ethylene glycol)-Poly(beta-amino ester)-Poly(ethylene glycol) Triblock Micelles for Cancer Therapy by Kim, Jayoung, Shamul, James G, Shah, Sagar R, Shin, Alyssa, Lee, Ben J, Quinones-Hinojosa, Alfredo, Green, Jordan J

“…Amphiphilic polymers can be used to form micelles to deliver water-insoluble drugs. A biodegradable poly­(ethylene glycol) (PEG)-poly­(beta-amino ester)…”
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Brachyury-YAP Regulatory Axis Drives Stemness and Growth in Cancer by Shah, Sagar R., David, Justin M., Tippens, Nathaniel D., Mohyeldin, Ahmed, Martinez-Gutierrez, Juan C., Ganaha, Sara, Schiapparelli, Paula, Hamilton, Duane H., Palena, Claudia, Levchenko, Andre, Quiñones-Hinojosa, Alfredo

“…Molecular factors that define stem cell identity have recently emerged as oncogenic drivers. For instance, brachyury, a key developmental transcriptional…”
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Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes by Saeui, Christopher T, Nairn, Alison V, Galizzi, Melina, Douville, Christopher, Gowda, Prateek, Park, Marian, Dharmarha, Vrinda, Shah, Sagar R, Clarke, Amelia, Austin, Melissa, Moremen, Kelley W, Yarema, Kevin J

“…In this report we use 'high-flux' tributanoyl-modified N-acetylmannosamine (ManNAc) analogs with natural N-acetyl as well as non-natural azido- and alkyne…”
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A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm by Kilic, Onur, Yoon, Arum, Shah, Sagar R., Yong, Hwan Mee, Ruiz-Valls, Alejandro, Chang, Hao, Panettieri, Reynold A., Liggett, Stephen B., Quiñones-Hinojosa, Alfredo, An, Steven S., Levchenko, Andre

“…In asthma, the contraction of the airway smooth muscle and the subsequent decrease in airflow involve a poorly understood set of mechanical and biochemical…”
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Cell Line-, Protein-, and Sialoglycosite-Specific Control of Flux-Based Sialylation in Human Breast Cells: Implications for Cancer Progression by Saeui, Christopher T, Cho, Kyung-Cho, Dharmarha, Vrinda, Nairn, Alison V, Galizzi, Melina, Shah, Sagar R, Gowda, Prateek, Park, Marian, Austin, Melissa, Clarke, Amelia, Cai, Edward, Buettner, Matthew J, Ariss, Ryan, Moremen, Kelley W, Zhang, Hui, Yarema, Kevin J

“…Sialylation, a post-translational modification that impacts the structure, activity, and longevity of glycoproteins has been thought to be controlled primarily…”
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The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival by Hu, Yunping, Mintz, Akiva, Shah, Sagar R, Quinones-Hinojosa, Alfredo, Hsu, Wesley

“…Recent evidence suggests that the expression of brachyury is necessary for chordoma growth. However, the mechanism associated with brachyury-regulated cell…”
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Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants by Chen, You, Paramo, Mauricio I, Zhang, Yingying, Yao, Li, Shah, Sagar R, Jin, Yiyang, Zhang, Junke, Pan, Xiuqi, Yu, Haiyuan

“…Despite accumulating evidence implicating noncoding variants in human diseases, unraveling their functionality remains a significant challenge. Systematic…”
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Verteporfin-Loaded Polymeric Microparticles for Intratumoral Treatment of Brain Cancer by Shah, Sagar R, Kim, Jayoung, Schiapparelli, Paula, Vazquez-Ramos, Carla A, Martinez-Gutierrez, Juan C, Ruiz-Valls, Alejandro, Inman, Kyle, Shamul, James G, Green, Jordan J, Quinones-Hinojosa, Alfredo

“…Glioblastoma (GBMs) is the most common and aggressive type of primary brain tumor in adults with dismal prognosis despite radical surgical resection coupled…”
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Anticancer Properties of Hexosamine Analogs Designed to Attenuate Metabolic Flux through the Hexosamine Biosynthetic Pathway by Saeui, Christopher T., Shah, Sagar R., Fernandez-Gil, Beatriz I., Zhang, Cissy, Agatemor, Christian, Dammen-Brower, Kris, Mathew, Mohit P., Buettner, Matthew, Gowda, Prateek, Khare, Pratik, Otamendi-Lopez, Andrea, Yang, Shuang, Zhang, Hui, Le, Anne, Quinoñes-Hinojosa, Alfredo, Yarema, Kevin J.

“…Altered cellular metabolism is a hallmark of cancer pathogenesis and progression; for example, a near-universal feature of cancer is increased metabolic flux…”
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Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function by Schiapparelli, Paula, Pirman, Natasha L., Mohler, Kyle, Miranda-Herrera, Pierre A., Zarco, Natanael, Kilic, Onur, Miller, Chad, Shah, Sagar R., Rogulina, Svetlana, Hungerford, William, Abriola, Laura, Hoyer, Denton, Turk, Benjamin E., Guerrero-Cázares, Hugo, Isaacs, Farren J., Quiñones-Hinojosa, Alfredo, Levchenko, Andre, Rinehart, Jesse

“…Advances in genetic code expansion have enabled the production of proteins containing site-specific, authentic post-translational modifications. Here, we use a…”
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Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target: Laboratory investigation by HSU, Wesley, MOHYELDIN, Ahmed, WOLINSKY, Jean-Paul, GOKASLAN, Ziya L, QUINONES-HINOJOSA, Alfredo, SHAH, Sagar R, AP RHYS, Colette M, JOHNSON, Lakesha F, SEDORA-ROMAN, Neda I, KOSZTOWSKI, Thomas A, AWAD, Ola A, MCCARTHY, Edward F, LOEB, David M

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Urodynamics for clinically suspected obstruction after anti-incontinence surgery in women by Aponte, Margarita M, Shah, Sagar R, Hickling, Duane, Brucker, Benjamin M, Rosenblum, Nirit, Nitti, Victor W

“…We determined the usefulness of urodynamics in patients with obstruction secondary to anti-incontinence surgery. We retrospectively reviewed the records of all…”
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A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma by Wong, Bin Sheng, Shah, Sagar R., Yankaskas, Christopher L., Bajpai, Vivek K., Wu, Pei-Hsun, Chin, Deborah, Ifemembi, Brent, ReFaey, Karim, Schiapparelli, Paula, Zheng, Xiaobin, Martin, Stuart S., Fan, Chen-Ming, Quiñones-Hinojosa, Alfredo, Konstantopoulos, Konstantinos

“…Clinical scores, molecular markers and cellular phenotypes have been used to predict the clinical outcomes of patients with glioblastoma. However, their…”
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Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics by Shamul, James G, Shah, Sagar R, Kim, Jayoung, Schiapparelli, Paula, Vazquez-Ramos, Carla A, Lee, Ben J, Patel, Kisha K, Shin, Alyssa, Quinones-Hinojosa, Alfredo, Green, Jordan J

“…Nanomedicine can improve traditional therapies by enhancing the controlled release of drugs at targeted tissues in the body. However, there still exists…”
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Pre‐Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer by Smith, Chris L., Chaichana, Kaisorn L., Lee, Young M., Lin, Benjamin, Stanko, Kevin M., O'Donnell, Thomas, Gupta, Saksham, Shah, Sagar R., Wang, Joanne, Wijesekera, Olindi, Delannoy, Michael, Levchenko, Andre, Quiñones-Hinojosa, Alfredo

“…A reproducible, comprehensive, cell culture‐based approach to enhance human adipose mesenchymal stem cell (hAMSC) engraftment to brain tumors was developed…”
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217 YAP Is Ready to Rac and Rho: Elucidation of a Novel YAP-Driven Network That Potentiates Brain Cancer Cell Dispersal and Confers Poor Survival in Patients by Shah, Sagar R., Tippens, Nathaniel, Park, JinSeok, Mohyeldin, Ahmed, Vela, Guillermo, Martinez-Gutierrez, Juan Carlos, Margolis, Seth S, Schmidt, Susanne, Levchenko, Andre, Quinones-Hinojosa, Alfredo

“…Abstract INTRODUCTION: Molecular pathways linking cell polarization and migration to extracellular cues regulate many pathological processes, including…”
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Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP by Wei, Shuang, Wang, Jie, Oyinlade, Olutobi, Ma, Ding, Wang, Shuyan, Kratz, Lisa, Lal, Bachchu, Xu, Qingfu, Liu, Senquan, Shah, Sagar R., Zhang, Hao, Li, Yunqing, Quiñones-Hinojosa, Alfredo, Zhu, Heng, Huang, Zhi-yong, Cheng, Linzhao, Qian, Jiang, Xia, Shuli

“…Mutations in the isocitrate dehydrogenase 1 ( IDH1 ) gene have been identified in a number of cancer types, including brain cancer. The Cancer Genome Atlas…”
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Role of Cancer Stem Cells in Spine Tumors: Review of Current Literature by HSU, Wesley, MOHYELDIN, Ahmed, SHAH, Sagar R, GOKASLAN, Ziya L, QUINONES-HINOJOSA, Alfredo

“…The management of spinal column tumors continues to be a challenge for clinicians. The mechanisms of tumor recurrence after surgical intervention as well as…”
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