Search Results - "Shah, Richa B"

Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure by Shah, Richa B., Li, Yuanyuan, Yu, Honglin, Kini, Ela, Sidi, Samuel

“…SUMOylation regulates numerous cellular stress responses, yet targets in the apoptotic machinery remain elusive. We show that a single, DNA damage-induced…”
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NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus by Ando, Kiyohiro, Parsons, Melissa J, Shah, Richa B, Charendoff, Chloé I, Paris, Sheré L, Liu, Peter H, Fassio, Sara R, Rohrman, Brittany A, Thompson, Ruth, Oberst, Andrew, Sidi, Samuel, Bouchier-Hayes, Lisa

“…The PIDDosome (PIDD-RAIDD-caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet…”
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An Inhibitor of PIDDosome Formation by Thompson, Ruth, Shah, Richa B., Liu, Peter H., Gupta, Yogesh K., Ando, Kiyohiro, Aggarwal, Aneel K., Sidi, Samuel

“…The PIDDosome—PIDD-RAIDD-caspase-2 complex—is a proapoptotic caspase-activation platform of elusive significance. DNA damage can initiate complex assembly via…”
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Competing Bioaerosols May Influence the Seasonality of Influenza-Like Illnesses, including COVID-19. The Chicago Experience by Shah, Richa B., Shah, Rachna D., Retzinger, Damien G., Retzinger, Andrew C., Retzinger, Deborah A., Retzinger, Gregory S.

“…Data from Chicago confirm the end of flu season coincides with the beginning of pollen season. More importantly, the end of flu season also coincides with…”
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A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling by Li, Yuanyuan, Shah, Richa B, Sarti, Samanta, Belcher, Alicia L, Lee, Brian J, Gorbatenko, Andrej, Nemati, Francesca, Yu, Honglin, Stanley, Zoe, Rahman, Mahbuba, Shao, Zhengping, Silva, Jose M, Zha, Shan, Sidi, Samuel

“…Interleukin-1 receptor (IL-1R)-associated kinases (IRAKs) are core effectors of Toll-like receptors (TLRs) and IL-1R in innate immunity. Here, we found that…”
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An IRAK1–PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy by Liu, Peter H., Shah, Richa B., Li, Yuanyuan, Arora, Arshi, Ung, Peter Man-Un, Raman, Renuka, Gorbatenko, Andrej, Kozono, Shingo, Zhou, Xiao Zhen, Brechin, Vincent, Barbaro, John M., Thompson, Ruth, White, Richard M., Aguirre-Ghiso, Julio A., Heymach, John V., Lu, Kun Ping, Silva, Jose M., Panageas, Katherine S., Schlessinger, Avner, Maki, Robert G., Skinner, Heath D., de Stanchina, Elisa, Sidi, Samuel

“…Drug-based strategies to overcome tumour resistance to radiotherapy (R-RT) remain limited by the single-agent toxicity of traditional radiosensitizers (for…”
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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks by Shah, Richa B., Kernan, Jennifer L., van Hoogstraten, Anya, Ando, Kiyohiro, Li, Yuanyuan, Belcher, Alicia L., Mininger, Ivy, Bussenault, Andrei M., Raman, Renuka, Ramanagoudr-Bhojappa, Ramanagouda, Huang, Tony T., D’Andrea, Alan D., Chandrasekharappa, Settara C., Aggarwal, Aneel K., Thompson, Ruth, Sidi, Samuel

“…Cells counter DNA damage through repair or apoptosis, yet a direct mechanism for this choice has remained elusive. When facing interstrand crosslinks (ICLs),…”
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A mitosis-sensing caspase activation platform? New insights into the PIDDosome by Shah, Richa B., Thompson, Ruth, Sidi, Samuel

“…In contrast to the apoptosome and death-inducing signaling complex, the PIDDosome remains an orphan caspase activation platform unassigned to a specific…”
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