Search Results - "Shah, Jagesh V."

Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor by Rodriguez-Bravo, Veronica, Maciejowski, John, Corona, Jennifer, Buch, Håkon Kirkeby, Collin, Philippe, Kanemaki, Masato T., Shah, Jagesh V., Jallepalli, Prasad V.

“…The spindle assembly checkpoint (SAC) delays anaphase until all chromosomes are bioriented on the mitotic spindle. Under current models, unattached…”
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The ciliary transition zone: from morphology and molecules to medicine by Czarnecki, Peter G, Shah, Jagesh V

“…Researchers from various disciplines, including cell and developmental biology, genetics and molecular medicine, have revealed an exceptional diversity of…”
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Activation and control of p53 tetramerization in individual living cells by Gaglia, Giorgio, Guan, Yinghua, Shah, Jagesh V., Lahav, Galit

“…Homo-oligomerization is found in many biological systems and has been extensively studied in vitro. However, our ability to quantify and understand…”
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Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation by Besschetnova, Tatiana Y., Kolpakova-Hart, Elona, Guan, Yinghua, Zhou, Jing, Olsen, Bjorn R., Shah, Jagesh V.

“…The primary cilium acts as a transducer of extracellular stimuli into intracellular signaling [1, 2]. Its regulation, particularly with respect to length, has…”
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Cells in tight spaces: the role of cell shape in cell function by Shah, Jagesh V

“…In this issue, Pitaval et al. (2010. J. Cell Biol. doi:10.1083/jcb.201004003) demonstrate that cell geometry can regulate the elaboration of a primary cilium…”
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Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli by Jin, Xingjian, Mohieldin, Ashraf M, Muntean, Brian S, Green, Jill A, Shah, Jagesh V, Mykytyn, Kirk, Nauli, Surya M

“…Primary cilia with a diameter of ~200 nm have been implicated in development and disease. Calcium signaling within a primary cilium has never been directly…”
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Systematic proteomics of the VCP–UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis by Raman, Malavika, Sergeev, Mikhail, Garnaas, Maija, Lydeard, John R., Huttlin, Edward L., Goessling, Wolfram, Shah, Jagesh V., Harper, J. Wade

“…The AAA-ATPase VCP (also known as p97 or CDC48) uses ATP hydrolysis to ‘segregate’ ubiquitylated proteins from their binding partners. VCP acts through…”
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Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells by Prentice-Mott, Harrison V., Meroz, Yasmine, Carlson, Andreas, Levine, Michael A., Davidson, Michael W., Irimia, Daniel, Charras, Guillaume T., Mahadevan, L., Shah, Jagesh V.

“…Chemotaxis, the directional migration of cells in a chemical gradient, is robust to fluctuations associated with low chemical concentrations and dynamically…”
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Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments by Prentice-Mott, Harrison V., Chang, Chi-Han, Mahadevan, L., Mitchison, Timothy J., Irimia, Daniel, Shah, Jagesh V.

“…Cells integrate multiple measurement modalities to navigate their environment. Soluble and substrate-bound chemical gradients and physical cues have all been…”
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Noise Reduction in the Intracellular Pom1p Gradient by a Dynamic Clustering Mechanism by Saunders, Timothy E., Pan, Kally Z., Angel, Andrew, Guan, Yinghua, Shah, Jagesh V., Howard, Martin, Chang, Fred

“…Chemical gradients can generate pattern formation in biological systems. In the fission yeast Schizosaccharomyces pombe, a cortical gradient of pom1p…”
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The quantitative architecture of centromeric chromatin by Bodor, Dani L, Mata, João F, Sergeev, Mikhail, David, Ana Filipa, Salimian, Kevan J, Panchenko, Tanya, Cleveland, Don W, Black, Ben E, Shah, Jagesh V, Jansen, Lars Et

“…The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric…”
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Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles by Nielsen, Ian Helstrup, Rovsing, Anne Bruun, Janns, Jacob Hørlück, Thomsen, Emil Aagaard, Ruzo, Albert, Bøggild, Andreas, Nedergaard, Frederikke, Møller, Charlotte Thornild, Boesen, Thomas, Degn, Søren Egedal, Shah, Jagesh V., Mikkelsen, Jacob Giehm

“…To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of…”
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Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks by Hartlerode, Andrea J, Guan, Yinghua, Rajendran, Anbazhagan, Ura, Kiyoe, Schotta, Gunnar, Xie, Anyong, Shah, Jagesh V, Scully, Ralph

“…Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1…”
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Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1 by Kayatekin, Can, Matlack, Kent E. S., Hesse, William R., Guan, Yinghua, Chakrabortee, Sohini, Russ, Jenny, Wanker, Erich E., Shah, Jagesh V., Lindquist, Susan

“…Expansions of preexisting polyglutamine (polyQ) tracts in at least nine different proteins cause devastating neurodegenerative diseases. There are many unique…”
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Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins by Yunes, Sarah A, Willoughby, Jennifer L S, Kwan, Julian H, Biagi, Jessica M, Pokharel, Niranjana, Chin, Hang Gyeong, York, Emily A, Su, Kuan-Chung, George, Kelly, Shah, Jagesh V, Emili, Andrew, Schaus, Scott E, Hansen, Ulla

“…Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising…”
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ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning by Czarnecki, Peter G., Gabriel, George C., Manning, Danielle K., Sergeev, Mikhail, Lemke, Kristi, Klena, Nikolai T., Liu, Xiaoqin, Chen, Yu, Li, You, San Agustin, Jovenal T., Garnaas, Maija K., Francis, Richard J., Tobita, Kimimasa, Goessling, Wolfram, Pazour, Gregory J., Lo, Cecilia W., Beier, David R., Shah, Jagesh V.

“…The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study, we…”
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High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction by Goldmacher, Victor S, Audette, Charlene A, Guan, Yinghua, Sidhom, Eriene-Heidi, Shah, Jagesh V, Whiteman, Kathleen R, Kovtun, Yelena V

“…The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their…”
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Multi omics analysis of fibrotic kidneys in two mouse models by Pavkovic, Mira, Pantano, Lorena, Gerlach, Cory V., Brutus, Sergine, Boswell, Sarah A., Everley, Robert A., Shah, Jagesh V., Sui, Shannan H., Vaidya, Vishal S.

“…Kidney fibrosis represents an urgent unmet clinical need due to the lack of effective therapies and an inadequate understanding of the molecular pathogenesis…”
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Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint by Kops, Geert J. P. L, Shah, Jagesh V

“…With the goal of creating two genetically identical daughter cells, cell division culminates in the equal segregation of sister chromatids. This phase of cell…”
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Loss of the Ciliary Kinase Nek8 Causes Left-Right Asymmetry Defects by MANNING, Danielle K, SERGEEV, Mikhail, HEESBEEN, Roy G. Van, WONG, Michael D, OH, Jin-Hee, YAN LIU, MARK HENKELMAN, R, DRUMMOND, Lain, SHAH, Jagesh V, BEIER, David R

“…A missense mutation in mouse Nek8, which encodes a ciliary kinase, produces the juvenile cystic kidneys (jck) model of polycystic kidney disease, but the…”
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