Search Results - "Shah, Hardik"

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication by Zhang, Yuchen, Guo, Rui, Kim, Sharon H., Shah, Hardik, Zhang, Shuting, Liang, Jin Hua, Fang, Ying, Gentili, Matteo, Leary, Colin N. O’, Elledge, Steven J., Hung, Deborah T., Mootha, Vamsi K., Gewurz, Benjamin E.

“…The recently identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. How this novel beta-coronavirus…”
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S3641 Unraveling Rectal Bleeding in Appendiceal Cancer Post-Ileocolic Anastomosis with Metastasis to the Rectum: A Case Report by Awuah, Kojo-Frimpong B., Austin, Scarlett, Shah, Hardik

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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer by Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Er, Ekrem Emrah, Lopez-Soto, Alejandro, S. Jacob, Leni, Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R., Massagué, Joan

“…Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here…”
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A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci by Laverty, Kaitlin U, Stout, Jake M, Sullivan, Mitchell J, Shah, Hardik, Gill, Navdeep, Holbrook, Larry, Deikus, Gintaras, Sebra, Robert, Hughes, Timothy R, Page, Jonathan E, van Bakel, Harm

“…is widely cultivated for medicinal, food, industrial, and recreational use, but much remains unknown regarding its genetics, including the molecular…”
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Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS by Shi, Xiaojian, Reinstadler, Bryn, Shah, Hardik, To, Tsz-Leung, Byrne, Katie, Summer, Luanna, Calvo, Sarah E., Goldberger, Olga, Doench, John G., Mootha, Vamsi K., Shen, Hongying

“…The SLC25 carrier family consists of 53 transporters that shuttle nutrients and co-factors across mitochondrial membranes. The family is highly redundant and…”
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Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing by Reuter, Michael, Berninger, Philipp, Chuma, Shinichiro, Shah, Hardik, Hosokawa, Mihoko, Funaya, Charlotta, Antony, Claude, Sachidanandam, Ravi, Pillai, Ramesh S.

“…Piwi protein Miwi is shown to be a small RNA-guided RNase in mice; disrupting the catalytic activity of Miwi results in increased accumulation of LINE1…”
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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH by Intlekofer, Andrew M, Wang, Bo, Liu, Hui, Shah, Hardik, Carmona-Fontaine, Carlos, Rustenburg, Ariën S, Salah, Salah, Gunner, M R, Chodera, John D, Cross, Justin R, Thompson, Craig B

“…Acidification enhances lactate dehydrogenase– and malate dehydrogenase–mediated promiscuous production of L -2-hydroxyglutarate ( L -2HG) from α-ketoglutarate…”
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PET/CT in the Diagnosis and Workup of Sarcoidosis: Focus on Atypical Manifestations by Akaike, Gensuke, Itani, Malak, Shah, Hardik, Ahuja, Jitesh, Yilmaz Gunes, Burcak, Assaker, Richard, Behnia, Fatemeh

“…Sarcoidosis is a multisystem disease characterized by the formation of noncaseating granulomas. Lung and intrathoracic lymph nodes are classic sites of…”
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An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance by Patgiri, Anupam, Skinner, Owen S., Miyazaki, Yusuke, Schleifer, Grigorij, Marutani, Eizo, Shah, Hardik, Sharma, Rohit, Goodman, Russell P., To, Tsz-Leung, Robert Bao, Xiaoyan, Ichinose, Fumito, Zapol, Warren M., Mootha, Vamsi K.

“…An elevated intracellular NADH:NAD + ratio, or ‘reductive stress’, has been associated with multiple diseases, including disorders of the mitochondrial…”
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A functional genomics predictive network model identifies regulators of inflammatory bowel disease by Peters, Lauren A, Perrigoue, Jacqueline, Mortha, Arthur, Iuga, Alina, Song, Won-min, Neiman, Eric M, Llewellyn, Sean R, Di Narzo, Antonio, Kidd, Brian A, Telesco, Shannon E, Zhao, Yongzhong, Stojmirovic, Aleksandar, Sendecki, Jocelyn, Shameer, Khader, Miotto, Riccardo, Losic, Bojan, Shah, Hardik, Lee, Eunjee, Wang, Minghui, Faith, Jeremiah J, Kasarskis, Andrew, Brodmerkel, Carrie, Curran, Mark, Das, Anuk, Friedman, Joshua R, Fukui, Yoshinori, Humphrey, Mary Beth, Iritani, Brian M, Sibinga, Nicholas, Tarrant, Teresa K, Argmann, Carmen, Hao, Ke, Roussos, Panos, Zhu, Jun, Zhang, Bin, Dobrin, Radu, Mayer, Lloyd F, Schadt, Eric E

“…Eric Schadt and colleagues present a predictive causal model of the immune component of inflammatory bowel disease through integration of genetic, regulatory…”
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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs by Cornacchia, Daniela, Zhang, Chao, Zimmer, Bastian, Chung, Sun Young, Fan, Yujie, Soliman, Mohamed A., Tchieu, Jason, Chambers, Stuart M., Shah, Hardik, Paull, Daniel, Konrad, Csaba, Vincendeau, Michelle, Noggle, Scott A., Manfredi, Giovanni, Finley, Lydia W.S., Cross, Justin R., Betel, Doron, Studer, Lorenz

“…Current challenges in capturing naive human pluripotent stem cells (hPSCs) suggest that the factors regulating human naive versus primed pluripotency remain…”
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Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation by Monticelli, Laurel A, Buck, Michael D, Flamar, Anne-Laure, Saenz, Steven A, Tait Wojno, Elia D, Yudanin, Naomi A, Osborne, Lisa C, Hepworth, Matthew R, Tran, Sara V, Rodewald, Hans-Reimer, Shah, Hardik, Cross, Justin R, Diamond, Joshua M, Cantu, Edward, Christie, Jason D, Pearce, Erika L, Artis, David

“…The cell-intrinsic pathways controlling the function of innate lymphoid cells are poorly defined. Artis and colleagues demonstrate that ILC2s selectively…”
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A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering by To, Tsz-Leung, Cuadros, Alejandro M., Shah, Hardik, Hung, Wendy H.W., Li, Yang, Kim, Sharon H., Rubin, Daniel H.F., Boe, Ryan H., Rath, Sneha, Eaton, John K., Piccioni, Federica, Goodale, Amy, Kalani, Zohra, Doench, John G., Root, David E., Schreiber, Stuart L., Vafai, Scott B., Mootha, Vamsi K.

“…Mitochondrial dysfunction is associated with a spectrum of human conditions, ranging from rare, inborn errors of metabolism to the aging process. To identify…”
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Impacts and Industrial Applications of Phytic Acid and Phytase by Prajapati, Madhvi, Shah, Hardik

“…Phytic acid is an antinutritional compound that chelates P and essential divalent cations such as Fe, Ca, and Zn in cereals and major staple crops such as…”
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Mucin-producing Cystic Hepatobiliary Neoplasms: Updated Nomenclature and Clinical, Pathologic, and Imaging Features by Lee, Matthew H., Katabathina, Venkata S., Lubner, Meghan G., Shah, Hardik U., Prasad, Srinivasa R., Matkowskyj, Kristina A., Pickhardt, Perry J.

“…Cystic hepatobiliary neoplasms with mucin-producing epithelium—mucinous cystic neoplasm of the liver (MCN) and intraductal papillary neoplasm of the bile duct…”
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microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial–mesenchymal transition by Parikh, Aditya, Lee, Christine, Joseph, Peronne, Marchini, Sergio, Baccarini, Alessia, Kolev, Valentin, Romualdi, Chiara, Fruscio, Robert, Shah, Hardik, Wang, Feng, Mullokandov, Gavriel, Fishman, David, D’Incalci, Maurizio, Rahaman, Jamal, Kalir, Tamara, Redline, Raymond W., Brown, Brian D., Narla, Goutham, DiFeo, Analisa

“…Ovarian cancer is a leading cause of cancer deaths among women. Effective targets to treat advanced epithelial ovarian cancer (EOC) and biomarkers to predict…”
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Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome by Girdhar, Kiran, Hoffman, Gabriel E., Jiang, Yan, Brown, Leanne, Kundakovic, Marija, Hauberg, Mads E., Francoeur, Nancy J., Wang, Ying-chih, Shah, Hardik, Kavanagh, David H., Zharovsky, Elizabeth, Jacobov, Rivka, Wiseman, Jennifer R., Park, Royce, Johnson, Jessica S., Kassim, Bibi S., Sloofman, Laura, Mattei, Eugenio, Weng, Zhiping, Sieberts, Solveig K., Peters, Mette A., Harris, Brent T., Lipska, Barbara K., Sklar, Pamela, Roussos, Panos, Akbarian, Schahram

“…Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly…”
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CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder by Hoffman, Gabriel E., Bendl, Jaroslav, Voloudakis, Georgios, Montgomery, Kelsey S., Sloofman, Laura, Wang, Ying-Chih, Shah, Hardik R., Hauberg, Mads E., Johnson, Jessica S., Girdhar, Kiran, Song, Lingyun, Fullard, John F., Kramer, Robin, Hahn, Chang-Gyu, Gur, Raquel, Marenco, Stefano, Lipska, Barbara K., Lewis, David A., Haroutunian, Vahram, Hemby, Scott, Sullivan, Patrick, Akbarian, Schahram, Chess, Andrew, Buxbaum, Joseph D., Crawford, Greg E., Domenici, Enrico, Devlin, Bernie, Sieberts, Solveig K., Peters, Mette A., Roussos, Panos

“…Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic…”
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Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis by Apiz Saab, Juan J, Dzierozynski, Lindsey N, Jonker, Patrick B, AminiTabrizi, Roya, Shah, Hardik, Menjivar, Rosa Elena, Scott, Andrew J, Nwosu, Zeribe C, Zhu, Zhou, Chen, Riona N, Oh, Moses, Sheehan, Colin, Wahl, Daniel R, Pasca di Magliano, Marina, Lyssiotis, Costas A, Macleod, Kay F, Weber, Christopher R, Muir, Alexander

“…Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge…”
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Vitamin B6 Addiction in Acute Myeloid Leukemia by Chen, Chi-Chao, Li, Bo, Millman, Scott E., Chen, Cynthia, Li, Xiang, Morris, John P., Mayle, Allison, Ho, Yu-Jui, Loizou, Evangelia, Liu, Hui, Qin, Weige, Shah, Hardik, Violante, Sara, Cross, Justin R., Lowe, Scott W., Zhang, Lingbo

“…Cancer cells rely on altered metabolism to support abnormal proliferation. We performed a CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and…”
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