Search Results - "Shah, Disha"
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Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-11-2023)“…Pulmonary infections have been a leading etiology of morbidity and mortality worldwide. Upper and lower respiratory tract infections have multifactorial…”
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The power of using functional fMRI on small rodents to study brain pharmacology and disease
Published in Frontiers in pharmacology (21-10-2015)“…Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of pharmacological modulations on brain function in a non-invasive and…”
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3
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
Published in Nature communications (01-08-2019)“…Copy-number variants of the CYFIP1 gene in humans have been linked to autism spectrum disorders (ASD) and schizophrenia (SCZ), two neuropsychiatric disorders…”
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4
Biogenic metallic nanoparticles: from green synthesis to clinical translation
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-11-2024)“…Biogenic metallic nanoparticles (NPs) have garnered significant attention in recent years due to their unique properties and various applications in different…”
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Combating relapsed and refractory Mantle cell lymphoma with novel therapeutic armamentarium: Recent advances and clinical prospects
Published in Critical reviews in oncology/hematology (01-10-2023)“…Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin’s lymphoma (NHL), accounting for 5% of all cases. Due to its virulence factor, it is an…”
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Disable 2, A Versatile Tissue Matrix Multifunctional Scaffold Protein with Multifaceted Signaling: Unveiling Role in Breast Cancer for Therapeutic Revolution
Published in Cell biochemistry and biophysics (01-06-2024)“…The Disabled-2 (DAB2) protein, found in 80–90% of various tumors, including breast cancer, has been identified as a potential tumor suppressor protein. On the…”
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Disabled-2, a versatile tissue matrix multifunctional scaffold protein with multifaceted signaling: Unveiling its potential in the cancer battle
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-08-2024)“…A multifunctional scaffold protein termed Disabled-2 (Dab2) has recently gained attention in the scientific community and has emerged as a promising candidate…”
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8
Revamping the innate or innate-like immune cell-based therapy for hepatocellular carcinoma: new mechanistic insights and advanced opportunities
Published in Medical oncology (Northwood, London, England) (21-01-2023)“…A cancerous tumour termed hepatocellular carcinoma (HCC) is characterized by inflammation and subsequently followed by end-stage liver disease and necrosis of…”
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A bio-refinery concept for production of bio-methane and bio-ethanol from nitric acid pre-treated corncob and recovery of a high value fuel from a waste stream
Published in Renewable energy (01-11-2018)“…The present paper reports the bio-refinery concept on exploiting the pre-treated non-detoxified corncob hydrolysate for bio-gas production and simultaneously…”
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Valorised Calcium-Rich Biomass from Fish Waste and Eggshells in the Fabrication of Antibacterial Scaffold for Wound Healing Applications: A Review
Published in Waste and biomass valorization (01-04-2024)“…Tissue engineering deploys cell-seeded scaffolds with good biocompatibility, robust microstructure, mechanical characteristics, and controlled…”
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Resting-state functional MRI and [18F]-FDG PET demonstrate differences in neuronal activity between commonly used mouse strains
Published in NeuroImage (Orlando, Fla.) (15-01-2016)“…The existence of numerous interesting mouse models of neurological disorders enables the investigation of causal relations between pathological events and the…”
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Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity
Published in Scientific reports (07-11-2016)“…Intracerebral injection of the excitotoxic, endogenous tryptophan metabolite, quinolinic acid (QA), constitutes a chemical model of neurodegenerative brain…”
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Quasi-Periodic Patterns of Neural Activity improve Classification of Alzheimer’s Disease in Mice
Published in Scientific reports (03-07-2018)“…Resting state (rs)fMRI allows measurement of brain functional connectivity and has identified default mode (DMN) and task positive (TPN) network disruptions as…”
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Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition
Published in Alzheimer's & dementia (01-09-2016)“…Abstract Introduction In Alzheimer's disease (AD), pathologic amyloid-beta (Aβ) is synaptotoxic and impairs neuronal function at the microscale, influencing…”
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Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis
Published in PloS one (17-12-2013)“…Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD…”
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Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain
Published in Brain Structure and Function (01-07-2016)“…Resting-state functional MRI (rsfMRI) is a widely implemented technique used to investigate large-scale topology in the human brain during health and disease…”
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Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI
Published in NeuroImage (Orlando, Fla.) (01-04-2015)“…The cholinergic system is involved in learning and memory and is affected in neurodegenerative disorders such as Alzheimer's disease. The possibility of…”
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d-α-tocopheryl polyethylene glycol 1000 succinate surface scaffold polysarcosine based polymeric nanoparticles of enzalutamide for the treatment of colorectal cancer: In vitro, in vivo characterizations
Published in Heliyon (15-02-2024)“…In this study, Enzalutamide (ENZ) loaded Poly Lactic-co-Glycolic Acid (PLGA) nanoparticles coated with polysarcosine and d-α-Tocopheryl polyethylene glycol…”
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Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition
Published in Behavioural brain research (17-05-2019)“…Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer’s disease (AD), but their role in functional impairment is still debated. High levels of…”
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An Insight on Microfluidic Organ-on-a-Chip Models for PM2.5-Induced Pulmonary Complications
Published in ACS omega (26-03-2024)“…Pulmonary diseases like asthma, chronic obstructive pulmonary disorder, lung fibrosis, and lung cancer pose a significant burden to global human health. Many…”
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