Search Results - "Shah, Binal N."

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk by Zhang, De-Liang, Wu, Jian, Shah, Binal N, Greutélaers, Katja C, Ghosh, Manik C, Ollivierre, Hayden, Su, Xin-Zhuan, Thuma, Philip E, Bedu-Addo, George, Mockenhaupt, Frank P, Gordeuk, Victor R, Rouault, Tracey A

“…Malaria parasites invade red blood cells (RBCs), consume copious amounts of hemoglobin, and severely disrupt iron regulation in humans. Anemia often…”
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Gene expression changes in sickle cell reticulocytes and their clinical associations by Zhang, Xu, Song, Jihyun, Shah, Binal N., Han, Jin, Hassan, Taif, Miasniakova, Galina, Sergueeva, Adelina, Nekhai, Sergei, Machado, Roberto F., Gladwin, Mark T., Saraf, Santosh L., Prchal, Josef T., Gordeuk, Victor R.

“…Transcriptional changes in compensatory erythropoiesis in sickle cell anemia (SCA) and their disease modulation are unclear. We detected 1226 differentially…”
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Publisher Correction: Gene expression changes in sickle cell reticulocytes and their clinical associations by Zhang, Xu, Song, Jihyun, Shah, Binal N., Han, Jin, Hassan, Taif, Miasniakova, Galina, Sergueeva, Adelina, Nekhai, Sergei, Machado, Roberto F., Gladwin, Mark T., Saraf, Santosh L., Prchal, Josef T., Gordeuk, Victor R.

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Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells by Chesnokov, Mikhail S., Halasi, Marianna, Borhani, Soheila, Arbieva, Zarema, Shah, Binal N., Oerlemans, Rick, Khan, Irum, Camacho, Carlos J., Gartel, Andrei L.

“…FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in multiple cancers. Pharmacological inhibition of FOXM1 is a promising…”
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APOL1, α-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia by Saraf, Santosh L, Shah, Binal N, Zhang, Xu, Han, Jin, Tayo, Bamidele O, Abbasi, Taimur, Ostrower, Adam, Guzman, Elizabeth, Molokie, Robert E, Gowhari, Michel, Hassan, Johara, Jain, Shivi, Cooper, Richard S, Machado, Roberto F, Lash, James P, Gordeuk, Victor R

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Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell disease by Srisuwananukorn, Andrew, Raslan, Rasha, Zhang, Xu, Shah, Binal N., Han, Jin, Gowhari, Michel, Molokie, Robert E., Gordeuk, Victor R., Saraf, Santosh L.

“…Sickle cell disease (SCD) patients are at a four- to 100-fold increased risk for thrombosis compared with the general population, although the mechanisms and…”
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Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia by Sergueeva, Adelina, Miasnikova, Galina, Shah, Binal N, Song, Jihyun, Lisina, Ekaterina, Okhotin, Daniel J, Nouraie, Mehdi, Nekhai, Sergei, Ammosova, Tatiana, Niu, Xiao Mei, Prchal, Josef T, Zhang, Xu, Gordeuk, Victor R

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Effects of renin‐angiotensin blockade and APOL1 on kidney function in sickle cell disease by Han, Jin, Srisuwananukorn, Andrew, Shah, Binal N., Molokie, Robert E., Lash, James P., Gordeuk, Victor R., Saraf, Santosh L.

“…[ 1] Treatments for SCD-related kidney disease have been adopted from therapies used to treat other causes of kidney disease (angiotensin converting…”
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Alkaline phosphatase as a marker for painful vaso‐occlusive events and other acute complications in sickle cell disease by Han, Jin, Zhang, Xu, Shah, Binal N., Saraf, Santosh L., Gordeuk, Victor R.

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Platelet count decline and high neutrophil count within the first day of admission for painful sickle cell vaso‐occlusive episodes predict severe complications by Zhang, Xu, Han, Jin, Shah, Binal N., Saraf, Santosh L., Gordeuk, Victor R.

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Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts by Saraf, Santosh L., Akingbola, Titilola S., Shah, Binal N., Ezekekwu, Chinedu A., Sonubi, Omowunmi, Zhang, Xu, Hsu, Lewis L., Gladwin, Mark T., Machado, Roberto F., Cooper, Richard S., Gordeuk, Victor R., Tayo, Bamidele O.

“…α-Thalassemia and the BCL11A rs1427407 T allele are commonly observed in sickle cell anemia (SCA) patients and are associated with reduced hemolysis and higher…”
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Associations of hemolysis and anemia with cardiopulmonary dysfunction in an adult sickle cell disease cohort by Njoku, Franklin, Zhang, Xu, Shah, Binal N., Han, Jin, Machado, Roberto, Saraf, Santosh L., Gordeuk, Victor R.

“…•Hemolysis and anemia are distinct but inter-related pathophysiological processes that underlie end-organ dysfunction in sickle cell disease.•Principal…”
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Biomarkers of clinical severity in treated and untreated sickle cell disease: a comparison by genotypes of a single center cohort and African Americans in the NHANES study by Njoku, Franklin, Zhang, Xu, Shah, Binal N., Machado, Roberto F., Han, Jin, Saraf, Santosh L., Gordeuk, Victor R.

“…Summary Haemolysis and vaso‐occlusion underlie multi‐organ system complications in sickle cell disease (SCD). We assessed real‐world biomarkers in University…”
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Peripheral blood mononuclear cells show prominent gene expression by erythroid progenitors in diseases characterized by heightened erythropoiesis by Zhang, Xu, Song, Jihyun, Shah, Binal N., Nekhai, Sergei, Miasnikova, Galina, Sergueeva, Adelina, Prchal, Josef T., Gordeuk, Victor R.

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Increased transferrin protects from thrombosis in Chuvash erythrocytosis by Shah, Binal N, Zhang, Xu, Sergueeva, Adelina I, Miasnikova, Galina Y, Ganz, Tomas, Prchal, Josef T, Gordeuk, Victor R

“…Von Hippel-Lindau protein (VHL) is essential to hypoxic regulation of cellular processes. VHL promotes proteolytic clearance of hypoxia-inducible transcription…”
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Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy by Saraf, Santosh L., Zhang, Xu, Shah, Binal N., Raslan, Rasha, Tayo, Bamidele O., Lash, James P., Franceschini, Nora, Gordeuk, Victor R.

“…Sickle cell disease (SCD) and apolipoprotein L1 (APOL1) G1/G2 variants increase chronic kidney disease (CKD) risk in African Americans by poorly understood…”
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Increased iron stores influence glucose metabolism in sickle cell anaemia by Shah, Binal N., Hassan, Taif O., Zhang, Xu, McClain, Donald A., Gordeuk, Victor R.

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Honokiol is a FOXM1 antagonist by Halasi, Marianna, Hitchinson, Ben, Shah, Binal N., Váraljai, Renáta, Khan, Irum, Benevolenskaya, Elizaveta V., Gaponenko, Vadim, Arbiser, Jack L., Gartel, Andrei L.

“…Honokiol is a natural product and an emerging drug for a wide variety of malignancies, including hematopoietic malignancies, sarcomas, and common epithelial…”
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Thrombomodulin and multiorgan failure in sickle cell anemia by Ruiz, Maria Armila, Shah, Binal N., Ren, Guohui, Shuey, David, Minshall, Richard D., Gordeuk, Victor R., Saraf, Santosh L.

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HMOX1 and acute kidney injury in sickle cell anemia by Saraf, Santosh L., Viner, Maya, Rischall, Ariel, Raslan, Rasha, Shah, Binal N., Zhang, Xu, Han, Jin, Gowhari, Michel, Jain, Shivi, Molokie, Robert E., Machado, Roberto F., Lash, James P., Gordeuk, Victor R.

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