Search Results - "Shah, Ajay M."

Cardiac monocytes and macrophages after myocardial infarction by Peet, Claire, Ivetic, Aleksandar, Bromage, Daniel I, Shah, Ajay M

“…Abstract Improvements in early interventions after acute myocardial infarction (AMI), notably, the increased use of timely reperfusion therapy, have increased…”
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In search of new therapeutic targets and strategies for heart failure: recent advances in basic science by Shah, Ajay M, Prof, Mann, Douglas L, Prof

“…Summary Chronic heart failure continues to impose a substantial health-care burden, despite recent treatment advances. The key pathophysiological process that…”
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Cardiometabolic outcomes up to 12 months after COVID-19 infection. A matched cohort study in the UK by Rezel-Potts, Emma, Douiri, Abdel, Sun, Xiaohui, Chowienczyk, Phillip J, Shah, Ajay M, Gulliford, Martin C

“…Acute Coronavirus Disease 2019 (COVID-19) has been associated with new-onset cardiovascular disease (CVD) and diabetes mellitus (DM), but it is not known…”
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Redox Signaling in Cardiac Physiology and Pathology by Burgoyne, Joseph R, Mongue-Din, Héloïse, Eaton, Philip, Shah, Ajay M

“…Redox signaling refers to the specific and usually reversible oxidation/reduction modification of molecules involved in cellular signaling pathways. In the…”
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The impact of COVID‐19 on heart failure hospitalization and management: report from a Heart Failure Unit in London during the peak of the pandemic by Bromage, Daniel I., Cannatà, Antonio, Rind, Irfan A., Gregorio, Caterina, Piper, Susan, Shah, Ajay M., McDonagh, Theresa A.

“…Aims To examine the impact of COVID‐19 on acute heart failure (AHF) hospitalization rates, clinical characteristics and management of patients admitted to a…”
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Role of oxidative stress in calcific aortic valve disease and its therapeutic implications by Greenberg, Harry Z E, Zhao, Guoan, Shah, Ajay M, Zhang, Min

“…Abstract Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to the progressive fibrosis and calcification of aortic…”
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Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries by Wang, Mingyi, Shah, Ajay M

“…Abstract The aging population is increasing dramatically. Aging-associated stress simultaneously drives proinflammatory remodeling, involving angiotensin II…”
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Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload by Smyrnias, Ioannis, Gray, Stephen P., Okonko, Darlington O., Sawyer, Greta, Zoccarato, Anna, Catibog, Norman, López, Begoña, González, Arantxa, Ravassa, Susana, Díez, Javier, Shah, Ajay M.

“…The mitochondrial unfolded protein response (UPRmt) is activated when misfolded proteins accumulate within mitochondria and leads to increased expression of…”
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A machine learning approach for the prediction of pulmonary hypertension by Leha, Andreas, Hellenkamp, Kristian, Unsöld, Bernhard, Mushemi-Blake, Sitali, Shah, Ajay M, Hasenfuß, Gerd, Seidler, Tim

“…Machine learning (ML) is a powerful tool for identifying and structuring several informative variables for predictive tasks. Here, we investigated how ML…”
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Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration by Magadum, Ajit, Singh, Neha, Kurian, Ann Anu, Munir, Irsa, Mehmood, Talha, Brown, Kemar, Sharkar, Mohammad Tofael Kabir, Chepurko, Elena, Sassi, Yassine, Oh, Jae Gyun, Lee, Philyoung, Santos, Celio X.C., Gaziel-Sovran, Avital, Zhang, Guoan, Cai, Chen-Leng, Kho, Changwon, Mayr, Manuel, Shah, Ajay M., Hajjar, Roger J., Zangi, Lior

“…BACKGROUND:The adult mammalian heart has limited regenerative capacity, mostly attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2…”
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Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer by Tiwari, Payal, Blank, Ariane, Cui, Chang, Schoenfelt, Kelly Q, Zhou, Guolin, Xu, Yanfei, Khramtsova, Galina, Olopade, Funmi, Shah, Ajay M, Khan, Seema A, Rosner, Marsha Rich, Becker, Lev

“…Obesity is associated with increased incidence and severity of triple-negative breast cancer (TNBC); however, mechanisms underlying this relationship are…”
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SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care by Gutmann, Clemens, Takov, Kaloyan, Burnap, Sean A., Singh, Bhawana, Ali, Hashim, Theofilatos, Konstantinos, Reed, Ella, Hasman, Maria, Nabeebaccus, Adam, Fish, Matthew, McPhail, Mark JW, O’Gallagher, Kevin, Schmidt, Lukas E., Cassel, Christian, Rienks, Marieke, Yin, Xiaoke, Auzinger, Georg, Napoli, Salvatore, Mujib, Salma F., Trovato, Francesca, Sanderson, Barnaby, Merrick, Blair, Niazi, Umar, Saqi, Mansoor, Dimitrakopoulou, Konstantina, Fernández-Leiro, Rafael, Braun, Silke, Kronstein-Wiedemann, Romy, Doores, Katie J., Edgeworth, Jonathan D., Shah, Ajay M., Bornstein, Stefan R., Tonn, Torsten, Hayday, Adrian C., Giacca, Mauro, Shankar-Hari, Manu, Mayr, Manuel

“…Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples…”
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition by Yu, Min, Bardia, Aditya, Wittner, Ben S., Stott, Shannon L, Smas, Malgorzata E., Ting, David T., Isakoff, Steven J., Ciciliano, Jordan C., Wells, Marissa N., Shah, Ajay M., Concannon, Kyle F., Donaldson, Maria C., Sequist, Lecia V., Brachtel, Elena, Sgroi, Dennis, Baselga, Jose, Ramaswamy, Sridhar, Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala

“…Epithelial-mesenchymal transition (EMT) of adherent epithelial cells to a migratory mesenchymal state has been implicated in tumor metastasis in preclinical…”
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The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response by Puente, Bao N., Kimura, Wataru, Muralidhar, Shalini A., Moon, Jesung, Amatruda, James F., Phelps, Kate L., Grinsfelder, David, Rothermel, Beverly A., Chen, Rui, Garcia, Joseph A., Santos, Celio X., Thet, SuWannee, Mori, Eiichiro, Kinter, Michael T., Rindler, Paul M., Zacchigna, Serena, Mukherjee, Shibani, Chen, David J., Mahmoud, Ahmed I., Giacca, Mauro, Rabinovitch, Peter S., Asaithamby, Aroumougame, Shah, Ajay M., Szweda, Luke I., Sadek, Hesham A.

“…The mammalian heart has a remarkable regenerative capacity for a short period of time after birth, after which the majority of cardiomyocytes permanently exit…”
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Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase by Schröder, Katrin, Zhang, Min, Benkhoff, Sebastian, Mieth, Anja, Pliquett, Rainer, Kosowski, Judith, Kruse, Christoph, Luedike, Peter, Michaelis, U Ruth, Weissmann, Norbert, Dimmeler, Stefanie, Shah, Ajay M, Brandes, Ralf P

“…RATIONALE:The function of Nox4, a source of vascular H2O2, is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction. OBJECTIVE:We…”
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Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase by Prysyazhna, Oleksandra, Wolhuter, Kathryn, Switzer, Christopher, Santos, Celio, Yang, Xiaoping, Lynham, Steven, Shah, Ajay M, Eaton, Philip, Burgoyne, Joseph R

“…BACKGROUND:The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the…”
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Endothelial NADPH Oxidase-2 Promotes Interstitial Cardiac Fibrosis and Diastolic Dysfunction Through Proinflammatory Effects and Endothelial-Mesenchymal Transition by Murdoch, Colin E., PhD, Chaubey, Sanjay, MBBCh, PhD, Zeng, Lingfang, PhD, Yu, Bin, PhD, Ivetic, Aleksander, PhD, Walker, Simon J., BSc, Vanhoutte, Davy, PhD, Heymans, Stephane, MD, PhD, Grieve, David J., PhD, Cave, Alison C., PhD, Brewer, Alison C., PhD, Zhang, Min, MD, PhD, Shah, Ajay M., MD, FMedSci

“…Objectives This study sought to investigate the effect of endothelial dysfunction on the development of cardiac hypertrophy and fibrosis. Background…”
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The NADPH oxidase Nox4 has anti-atherosclerotic functions by Schürmann, Christoph, Rezende, Flavia, Kruse, Christoph, Yasar, Yakub, Löwe, Oliver, Fork, Christian, van de Sluis, Bart, Bremer, Rolf, Weissmann, Norbert, Shah, Ajay M, Jo, Hanjoong, Brandes, Ralf P, Schröder, Katrin

“…Oxidative stress is thought to be a risk for cardiovascular disease and NADPH oxidases of the Nox family are important producers of reactive oxygen species…”
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Echocardiographic evaluation of diastolic function in mouse models of heart disease by Schnelle, Moritz, Catibog, Norman, Zhang, Min, Nabeebaccus, Adam A., Anderson, Grace, Richards, Daniel A., Sawyer, Greta, Zhang, Xiaohong, Toischer, Karl, Hasenfuss, Gerd, Monaghan, Mark J., Shah, Ajay M.

“…Mouse models of heart disease are extensively employed. The echocardiographic characterization of contractile function is usually focused on systolic function…”
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Parsing the Role of NADPH Oxidase Enzymes and Reactive Oxygen Species in Heart Failure by Shah, Ajay M

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