Search Results - "Shafritz, David A."

Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes by Yovchev, Mladen I., Xue, Yuhua, Shafritz, David A., Locker, Joseph, Oertel, Michael

“…Considerable progress has been made in developing antifibrotic agents and other strategies to treat liver fibrosis; however, significant long‐term restoration…”
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BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm by Keller, Gordon, Gouon-Evans, Valerie, Boussemart, Lise, Gadue, Paul, Nierhoff, Dirk, Koehler, Christoph I, Kubo, Atsushi, Shafritz, David A

“…When differentiated in the presence of activin A in serum-free conditions, mouse embryonic stem cells efficiently generate an endoderm progenitor population…”
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Therapeutic Cell Repopulation of the Liver: From Fetal Rat Cells to Synthetic Human Tissues by Shafritz, David A, Ebrahimkhani, Mo R, Oertel, Michael

“…Progenitor cells isolated from the fetal liver can provide a unique cell source to generate new healthy tissue mass. Almost 20 years ago, it was demonstrated…”
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Cell Competition Leads to a High Level of Normal Liver Reconstitution by Transplanted Fetal Liver Stem/Progenitor Cells by Oertel, Michael, Menthena, Anuradha, Dabeva, Mariana D., Shafritz, David A.

“…Background & Aims: A critical property of stem cells is their ability to repopulate an organ or tissue under nonselective conditions. The aims of this study…”
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Purification of Fetal Liver Stem/Progenitor Cells Containing all the Repopulation Potential for Normal Adult Rat Liver by Oertel, Michael, Menthena, Anuradha, Chen, Yuan–Qing, Teisner, Børge, Jensen, Charlotte Harken, Shafritz, David A

“…Background & Aims: Previously, we showed high-level, long-term liver replacement after transplantation of unfractionated embryonic day (ED) 14 fetal liver…”
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HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver by Kollet, Orit, Shivtiel, Shoham, Chen, Yuan-Qing, Suriawinata, Jenny, Thung, Swan N, Dabeva, Mariana D, Kahn, Joy, Spiegel, Asaf, Dar, Ayelet, Samira, Sarit, Goichberg, Polina, Kalinkovich, Alexander, Arenzana-Seisdedos, Fernando, Nagler, Arnon, Hardan, Izhar, Revel, Michel, Shafritz, David A, Lapidot, Tsvee

“…Hematopoietic stem cells rarely contribute to hepatic regeneration, however, the mechanisms governing their homing to the liver, which is a crucial first step,…”
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Activin A, p15INK4b Signaling, and Cell Competition Promote Stem/Progenitor Cell Repopulation of Livers in Aging Rats by Menthena, Anuradha, Koehler, Christoph I, Sandhu, Jaswinderpal S, Yovchev, Mladen I, Hurston, Ethel, Shafritz, David A, Oertel, Michael

“…Background & Aims Highly proliferative fetal liver stem/progenitor cells (FLSPCs) repopulate livers of normal recipients by cell competition. We investigated…”
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Deletion of Smad2 in Mouse Liver Reveals Novel Functions in Hepatocyte Growth and Differentiation by Ju, Wenjun, Ogawa, Atsushi, Heyer, Joerg, Nierhof, Dirk, Yu, Liping, Kucherlapati, Raju, Shafritz, David A., Böttinger, Erwin P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Liver stem cells and prospects for liver reconstitution by transplanted cells by Shafritz, David A., Oertel, Michael, Menthena, Anuradha, Nierhoff, Dirk, Dabeva, Mariana D.

“…Although it was proposed almost 60 years ago that the adult mammalian liver contains hepatic stem cells, this issue remains controversial. Part of the problem…”
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New cell surface markers for murine fetal hepatic stem cells identified through high density complementary DNA microarrays by Nierhoff, Dirk, Levoci, Lauretta, Schulte, Sigrid, Goeser, Tobias, Rogler, Leslie E., Shafritz, David A.

“…Isolation of hepatic stem cells from the adult liver (AL) has not yet been achieved due to the lack of specific cell surface markers. To identify new surface…”
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Comparison of hepatic properties and transplantation of Thy‐1+ and Thy‐1− cells isolated from embryonic day 14 rat fetal liver by Oertel, Michael, Menthena, Anuradha, Chen, Yuan‐Qing, Shafritz, David A.

“…Thy‐1, a marker of hematopoietic progenitor cells, is also expressed in activated oval cells of rat liver. Thy‐1+ cells are also in rat fetal liver and exhibit…”
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Stem cells, cell transplantation and liver repopulation by Oertel, Michael, Shafritz, David A.

“…Liver transplantation is currently the only therapeutic option for patients with end-stage chronic liver disease and for severe acute liver failure. Because of…”
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Stem Cell Properties and Repopulation of the Rat Liver by Fetal Liver Epithelial Progenitor Cells by Sandhu, Jaswinderpal S., Petkov, Petko M., Dabeva, Mariana D., Shafritz, David A.

“…The potential of embryonal day (ED) 14 fetal liver epithelial progenitor (FLEP) cells from Fischer (F)344 rats to repopulate the normal and retrorsine-treated…”
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Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells by Shafritz, David A., Oertel, Michael

“…In recent years, there has been substantial progress in transplanting cells into the liver with the ultimate goal of restoring liver mass and function in both…”
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Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays by Petkov, Petko M., Zavadil, Jiri, Goetz, David, Chu, Tearina, Carver, Robert, Rogler, Charles E., Bottinger, Erwin P., Shafritz, David A., Dabeva, Mariana D.

“…To identify new and differentially expressed genes in rat fetal liver epithelial stem/progenitor cells during their proliferation, lineage commitment, and…”
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Inactivation of p27Kip1 promotes chemical mouse liver tumorigenesis in the resistant strain C57BL/6J by Sun, Daqian, Ren, Hao, Oertel, Michael, Sellers, Rani S., Shafritz, David A., Zhu, Liang

“…The biochemical function of p27Kip1 as an inhibitor of cyclin‐dependent kinases is well‐established, but the role of p27 as a tumor suppressor depends on…”
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To TWEAK, or not to TWEAK: That is the question by Shafritz, David A.

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HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver by Kollet, Orit, Shivtiel, Shoham, Chen, Yuan-Qing, Suriawinata, Jenny, Thung, Swan N., Dabeva, Mariana D., Kahn, Joy, Spiegel, Asaf, Dar, Ayelet, Samira, Sarit, Goichberg, Polina, Kalinkovich, Alexander, Arenzana-Seisdedos, Fernando, Nagler, Arnon, Hardan, Izhar, Revel, Michel, Shafritz, David A., Lapidot, Tsvee

“…Hematopoietic stem cells rarely contribute to hepatic regeneration, however, the mechanisms governing their homing to the liver, which is a crucial first step,…”
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Experimental Model for Successful Liver Cell Therapy by Lenti TTR-YapERT2 Transduced Hepatocytes with Tamoxifen Control of Yap Subcellular Location by Yovchev, Mladen, Jaber, Fadi L., Lu, Zhonglei, Patel, Shachi, Locker, Joseph, Rogler, Leslie E., Murray, John W., Sudol, Marius, Dabeva, Mariana D., Zhu, Liang, Shafritz, David A.

“…Liver repopulation by transplanted hepatocytes has not been achieved previously in a normal liver microenvironment. Here we report that adult rat hepatocytes…”
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A human hepatocyte factory by Shafritz, David A

“…Research on the human liver has been constrained by the difficulties of preparing primary human hepatocytes with good viability. Now a new mouse model allows…”
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