Bioactive oligostilbenoids from Shorea maxwelliana King and their chemotaxonomic significance

Bioactive oligostilbenoids from Shorea maxwelliana King and their chemotaxonomic significance

Phytochemical investigation on the stem bark of Shorea maxwelliana yielded five oligostilbenoids identified as α-viniferin (1), maximol A (2), vaticanol A (3), suffruticosol A (4) and vaticanol G (5). Chemotaxonomy of isolated compounds was discussed briefly. Major compounds were tested for neurotox...

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Bibliographic Details
Published in:Natural product research Vol. 27; no. 17; pp. 1589 - 1593
Main Authors: Zawawi, N.K.N.A., Ahmat, N., Mazatulikhma, M.Z., Shafiq, R.M., Wahid, N.H., Sufian, A.S.
Format: Journal Article
Language:English
Published: England Taylor & Francis Group 01-09-2013
Taylor & Francis Ltd
Subjects:
Bark
Benzofurans - chemistry
Benzofurans - pharmacology
bioactivities
Biocompatibility
Cell Survival - drug effects
Chemotaxonomy
Cytotoxicity
Dipterocarpaceae
Dipterocarpaceae - chemistry
HL-60 Cells
Humans
Neurotoxicity
oligostilbenes
Plant Bark - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Shorea maxwelliana
Stilbenes - chemistry
Stilbenes - pharmacology
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Summary:Phytochemical investigation on the stem bark of Shorea maxwelliana yielded five oligostilbenoids identified as α-viniferin (1), maximol A (2), vaticanol A (3), suffruticosol A (4) and vaticanol G (5). Chemotaxonomy of isolated compounds was discussed briefly. Major compounds were tested for neurotoxic and cytotoxic activities. Neurotoxicity for all tested compounds did not pose any toxic effect against cultured cell (cell viability range ±100-94%). Compounds 2-5 possessed active cyctotoxic activity against HL60 cell line with IC 50 values range of 2.7-78 µg mL −1 .
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2012.730047