Search Results - "Shafik, Sarah H."

The natural function of the malaria parasite’s chloroquine resistance transporter by Shafik, Sarah H., Cobbold, Simon A., Barkat, Kawthar, Richards, Sashika N., Lancaster, Nicole S., Llinás, Manuel, Hogg, Simon J., Summers, Robert L., McConville, Malcolm J., Martin, Rowena E.

“…The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also essential for the survival of the…”
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Identifying the major lactate transporter of Toxoplasma gondii tachyzoites by Zeng, Joy M., Hapuarachchi, Sanduni V., Shafik, Sarah H., Martin, Rowena E., Kirk, Kiaran, van Dooren, Giel G., Lehane, Adele M.

“…Toxoplasma gondii and Plasmodium falciparum parasites both extrude l -lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, Pf…”
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The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens by Hapuarachchi, Sanduni V, Cobbold, Simon A, Shafik, Sarah H, Dennis, Adelaide S M, McConville, Malcolm J, Martin, Rowena E, Kirk, Kiaran, Lehane, Adele M

“…In this study the 'Malaria Box' chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH…”
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Inferring a complete genotype-phenotype map from a small number of measured phenotypes by Sailer, Zachary R, Shafik, Sarah H, Summers, Robert L, Joule, Alex, Patterson-Robert, Alice, Martin, Rowena E, Harms, Michael J, Mac Gabhann, Feilim, Morozov, Alexandre V

“…Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a…”
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Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter by Richards, Sashika N, Nash, Megan N, Baker, Eileen S, Webster, Michael W, Lehane, Adele M, Shafik, Sarah H, Martin, Rowena E

“…Mutations in the Plasmodium falciparum 'chloroquine resistance transporter' (PfCRT) confer resistance to chloroquine (CQ) and related antimalarials by enabling…”
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1H-NMR metabolite profiles of different strains of Plasmodium falciparum by Teng, Rongwei, Lehane, Adele M, Winterberg, Markus, Shafik, Sarah H, Summers, Robert L, Martin, Rowena E, van Schalkwyk, Donelly A, Junankar, Pauline R, Kirk, Kiaran

“…Although efforts to understand the basis for inter-strain phenotypic variation in the most virulent malaria species, Plasmodium falciparum, have benefited from…”
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Mechanisms of resistance to the partner drugs of artemisinin in the malaria parasite by Martin, Rowena E, Shafik, Sarah H, Richards, Sashika N

“…•New targets and resistance determinants have been identified for ACT partner drugs.•Resistance to many of the ACT partner drugs involves multifactorial…”
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A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum by Marchetti, Rosa V., Lehane, Adele M., Shafik, Sarah H., Winterberg, Markus, Martin, Rowena E., Kirk, Kiaran

“…The intraerythrocytic malaria parasite relies primarily on glycolysis to fuel its rapid growth and reproduction. The major byproduct of this metabolism, lactic…”
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The role of SWEET4 proteins in the post-phloem sugar transport pathway of Setaria viridis sink tissues by Chen, Lily, Ganguly, Diep R, Shafik, Sarah H, Danila, Florence, Grof, Christopher P L, Sharwood, Robert E, Furbank, Robert T

“…Abstract In the developing seeds of all higher plants, filial cells are symplastically isolated from the maternal tissue supplying photosynthate to the…”
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Elucidating the role of SWEET13 in phloem loading of the C4 grass Setaria viridis by Chen, Lily, Ganguly, Diep R., Shafik, Sarah H., Ermakova, Maria, Pogson, Barry J., Grof, Christopher P. L., Sharwood, Robert E., Furbank, Robert T.

“…SUMMARY Photosynthetic efficiency and sink demand are tightly correlated with rates of phloem loading, where maintaining low cytosolic sugar concentrations is…”
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Elucidating the role of SWEET13 in phloem loading of the C 4 grass Setaria viridis by Chen, Lily, Ganguly, Diep R, Shafik, Sarah H, Ermakova, Maria, Pogson, Barry J, Grof, Christopher P L, Sharwood, Robert E, Furbank, Robert T

“…Photosynthetic efficiency and sink demand are tightly correlated with rates of phloem loading, where maintaining low cytosolic sugar concentrations is…”
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Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity by Relitti, Nicola, Federico, Stefano, Pozzetti, Luca, Butini, Stefania, Lamponi, Stefania, Taramelli, Donatella, D’Alessandro, Sarah, Martin, Rowena E., Shafik, Sarah H., Summers, Robert L., Babij, Simone K., Habluetzel, Annette, Tapanelli, Sofia, Caldelari, Reto, Gemma, Sandra, Campiani, Giuseppe

“…Due to the surge in resistance to common therapies, malaria remains a significant concern to human health worldwide. In chloroquine (CQ)-resistant (CQ-R)…”
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Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities by Pulcini, Serena, Staines, Henry M., Lee, Andrew H., Shafik, Sarah H., Bouyer, Guillaume, Moore, Catherine M., Daley, Daniel A., Hoke, Matthew J., Altenhofen, Lindsey M., Painter, Heather J., Mu, Jianbing, Ferguson, David J. P., Llinás, Manuel, Martin, Rowena E., Fidock, David A., Cooper, Roland A., Krishna, Sanjeev

“…Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human…”
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Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs by van Schalkwyk, Donelly A., Nash, Megan N., Shafik, Sarah H., Summers, Robert L., Lehane, Adele M., Smith, Peter J., Martin, Rowena E.

“…Background. It is becoming increasingly apparent that certain mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) alter the…”
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super(1)H-NMR metabolite profiles of different strains of Plasmodium falciparum by Teng, Rongwei, Lehane, Adele M, Winterberg, Markus, Shafik, Sarah H, Summers, Robert L, Martin, Rowena E, van Schalkwyk, Donelly A, Junankar, Pauline R, Kirk, Kiaran

“…Although efforts to understand the basis for inter-strain phenotypic variation in the most virulent malaria species, Plasmodium falciparum, have benefited from…”
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