Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Biocompatible and electrically conductive porous scaffolds with a desirable hydrophilicity and degradation rate and suitable mechanical performance are highly favorable for tissue engineering and regenerative medicine applications. In this study, we fabricated three‐dimensional (3D) porous bioscaffo...

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Bibliographic Details
Published in:Polymers for advanced technologies Vol. 33; no. 5; pp. 1427 - 1441
Main Authors: Jafari, Aliakbar, Mirzaei, Hadis, Shafiei, Mir Alireza, Fakhri, Vafa, Yazdanbakhsh, Amirhosein, Pirouzfar, Vahid, Su, Chia‐Hung, Ghaffarian Anbaran, S. Reza, Khonakdar, Hossein Ali
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01-05-2022
Wiley Subscription Services, Inc
Subjects:
Biocompatibility
Biodegradation
Electrical resistivity
electrically conductive bioscaffold
Hydrophilicity
Mechanical properties
Nanoparticles
poly(ε‐caprolactone)
Polycaprolactone
Polylactic acid
polypyrrole coating
Polypyrroles
Scaffolds
Synergistic effect
Tissue engineering
zirconia nanoparticles
Zirconium dioxide
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Summary:Biocompatible and electrically conductive porous scaffolds with a desirable hydrophilicity and degradation rate and suitable mechanical performance are highly favorable for tissue engineering and regenerative medicine applications. In this study, we fabricated three‐dimensional (3D) porous bioscaffolds from poly(ε‐caprolactone) and polylactic acid containing different concentrations of zirconia nanoparticles (n‐ZrO2) through freeze‐drying technique. Afterward, the surface of the scaffolds was coated with an electrically conductive layer through in situ polymerization of polypyrrole (PPy) on the samples. Bioscaffolds exhibited a favorable range of mechanical properties and electrical conductivity, meeting the required mechanical performances and conductivity for a broad range of tissue engineering applications. Coating PPy on the scaffolds resulted in significantly higher hydrophilicity and faster biodegradation rate, as well as a noticeable enhancement on the in vitro cell attachment, proliferation, and viability. Our findings indicated that the simultaneous presence of n‐ZrO2 and PPy in the system presents a noticeable synergistic effect in overall properties and introduces the fabricated 3D porous scaffolds as promising candidates for tissue engineering and regenerative medicine applications.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.5611