Search Results - "Shaffer, Scott A."

The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus by Singh, Guramrit, Kucukural, Alper, Cenik, Can, Leszyk, John D., Shaffer, Scott A., Weng, Zhiping, Moore, Melissa J.

“…In addition to sculpting eukaryotic transcripts by removing introns, pre-mRNA splicing greatly impacts protein composition of the emerging mRNP. The exon…”
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Succination inactivates gasdermin D and blocks pyroptosis by Humphries, Fiachra, Shmuel-Galia, Liraz, Ketelut-Carneiro, Natalia, Li, Sheng, Wang, Bingwei, Nemmara, Venkatesh V, Wilson, Ruth, Jiang, Zhaozhao, Khalighinejad, Farnaz, Muneeruddin, Khaja, Shaffer, Scott A, Dutta, Ranjan, Ionete, Carolina, Pesiridis, Scott, Yang, Shuo, Thompson, Paul R, Fitzgerald, Katherine A

“…Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs' cycle intermediates that alter transcription of immune response…”
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Transcription factor Foxp3 and its protein partners form a complex regulatory network by Rudra, Dipayan, deRoos, Paul, Chaudhry, Ashutosh, Niec, Rachel E, Arvey, Aaron, Samstein, Robert M, Leslie, Christina, Shaffer, Scott A, Goodlett, David R, Rudensky, Alexander Y

“…The transcription factor Foxp3 is essential for the function of regulatory T cells. Rudensky and colleagues show Foxp3 participates in large protein complexes…”
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Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation by Tian, Songhai, Muneeruddin, Khaja, Choi, Mei Yuk, Tao, Liang, Bhuiyan, Robiul H, Ohmi, Yuhsuke, Furukawa, Keiko, Furukawa, Koichi, Boland, Sebastian, Shaffer, Scott A, Adam, Rosalyn M, Dong, Min

“…Glycosylation is a fundamental modification of proteins and membrane lipids. Toxins that utilize glycans as their receptors have served as powerful tools to…”
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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells by Shmuel-Galia, Liraz, Humphries, Fiachra, Lei, Xuqiu, Ceglia, Simona, Wilson, Ruth, Jiang, Zhaozhao, Ketelut-Carneiro, Natalia, Foley, Sage E., Pechhold, Susanne, Houghton, JeanMarie, Muneeruddin, Khaja, Shaffer, Scott A., McCormick, Beth A., Reboldi, Andrea, Ward, Doyle, Marshak-Rothstein, Ann, Fitzgerald, Katherine A.

“…Alterations in the cGAS-STING DNA-sensing pathway affect intestinal homeostasis. We sought to delineate the functional role of STING in intestinal…”
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Key Questions in Marine Megafauna Movement Ecology by Hays, Graeme C., Ferreira, Luciana C., Sequeira, Ana M.M., Meekan, Mark G., Duarte, Carlos M., Bailey, Helen, Bailleul, Fred, Bowen, W. Don, Caley, M. Julian, Costa, Daniel P., Eguíluz, Victor M., Fossette, Sabrina, Friedlaender, Ari S., Gales, Nick, Gleiss, Adrian C., Gunn, John, Harcourt, Rob, Hazen, Elliott L., Heithaus, Michael R., Heupel, Michelle, Holland, Kim, Horning, Markus, Jonsen, Ian, Kooyman, Gerald L., Lowe, Christopher G., Madsen, Peter T., Marsh, Helene, Phillips, Richard A., Righton, David, Ropert-Coudert, Yan, Sato, Katsufumi, Shaffer, Scott A., Simpfendorfer, Colin A., Sims, David W., Skomal, Gregory, Takahashi, Akinori, Trathan, Philip N., Wikelski, Martin, Womble, Jamie N., Thums, Michele

“…It is a golden age for animal movement studies and so an opportune time to assess priorities for future work. We assembled 40 experts to identify key questions…”
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The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems by Nambi, Subhalaxmi, Long, Jarukit E., Mishra, Bibhuti B., Baker, Richard, Murphy, Kenan C., Olive, Andrew J., Nguyen, Hien P., Shaffer, Scott A., Sassetti, Christopher M.

“…M. tuberculosis (Mtb) survives a hostile environment within the host that is shaped in part by oxidative stress. The mechanisms used by Mtb to resist these…”
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Predicted habitat shifts of Pacific top predators in a changing climate by Hazen, Elliott L., Jorgensen, Salvador, Rykaczewski, Ryan R., Bograd, Steven J., Foley, David G., Jonsen, Ian D., Shaffer, Scott A., Dunne, John P., Costa, Daniel P., Crowder, Larry B., Block, Barbara A.

“…Climate change scenarios predict an average sea surface temperature rise of 1–6 °C by 2100. Now, a study investigating the potential effect of these changes on…”
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High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources by Haraszti, Reka A., Didiot, Marie-Cecile, Sapp, Ellen, Leszyk, John, Shaffer, Scott A., Rockwell, Hannah E., Gao, Fei, Narain, Niven R., DiFiglia, Marian, Kiebish, Michael A., Aronin, Neil, Khvorova, Anastasia

“…Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), are explored for use in diagnostics, therapeutics and drug delivery. However, little…”
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Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study by Deligiannidis, Kristina M, Fales, Christina L, Kroll-Desrosiers, Aimee R, Shaffer, Scott A, Villamarin, Vanessa, Tan, Yanglan, Hall, Janet E, Frederick, Blaise B, Sikoglu, Elif M, Edden, Richard A, Rothschild, Anthony J, Moore, Constance M

“…Postpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unclear. We…”
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Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain by You, Yang, Muraoka, Satoshi, Jedrychowski, Mark P., Hu, Jianqiao, McQuade, Amanda K., Young‐Pearse, Tracy, Aslebagh, Roshanak, Shaffer, Scott A., Gygi, Steven P., Blurton‐Jones, Mathew, Poon, Wayne W., Ikezu, Tsuneya

“…In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have…”
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A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination by Maurais, Aaron J, Salinger, Ari J, Tobin, Micaela, Shaffer, Scott A, Weerapana, Eranthie, Thompson, Paul R

“…Citrullination is an enzyme-catalyzed post-translational modification (PTM) that is essential for a host of biological processes, including gene regulation,…”
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Genetic variation shapes protein networks mainly through non-transcriptional mechanisms by Foss, Eric J, Radulovic, Dragan, Shaffer, Scott A, Goodlett, David R, Kruglyak, Leonid, Bedalov, Antonio

“…Networks of co-regulated transcripts in genetically diverse populations have been studied extensively, but little is known about the degree to which these…”
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Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria by Gallego-Marin, Carolina, Schrum, Jacob E, Andrade, Warrison A, Shaffer, Scott A, Giraldo, Lina F, Lasso, Alvaro M, Kurt-Jones, Evelyn A, Fitzgerald, Katherine A, Golenbock, Douglas T

“…Innate immune receptors have a key role in the sensing of malaria and initiating immune responses. As a consequence of infection, systemic inflammation emerges…”
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Pelagic marine protected areas protect foraging habitat for multiple breeding seabirds in the central Pacific by Young, Hillary S., Maxwell, Sara M., Conners, Melinda G., Shaffer, Scott A.

“…[Display omitted] •We examine the efficacy of pelagic marine protected areas in protecting seabird habitat.•Pelagic marine protected areas (PMPAs) protected…”
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Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury by Ambade, Aditya, Catalano, Donna, Lim, Arlene, Kopoyan, Andre, Shaffer, Scott A, Mandrekar, Pranoti

“…Background & Aims Heat shock protein 90 (hsp90) is an emerging therapeutic target in chronic liver diseases. Hsp90 plays an important role in liver immune cell…”
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Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4 by Andrade, Warrison A., Agarwal, Sarika, Mo, Shunyan, Shaffer, Scott A., Dillard, Joseph P., Schmidt, Tobias, Hornung, Veit, Fitzgerald, Katherine A., Kurt-Jones, Evelyn A., Golenbock, Douglas T.

“…The innate immune system is the first line of defense against Neisseria gonorrhoeae (GC). Exposure of cells to GC lipooligosaccharides induces a strong immune…”
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Wintering in the Western Subarctic Pacific Increases Mercury Contamination of Red-Legged Kittiwakes by Fleishman, Abram B, Orben, Rachael A, Kokubun, Nobuo, Will, Alexis, Paredes, Rosana, Ackerman, Joshua T, Takahashi, Akinori, Kitaysky, Alexander S, Shaffer, Scott A

“…Marine methylmercury concentrations vary geographically and with depth, exposing organisms to different mercury levels in different habitats. Red-legged…”
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Impacts of marine heatwaves on top predator distributions are variable but predictable by Welch, Heather, Savoca, Matthew S., Brodie, Stephanie, Jacox, Michael G., Muhling, Barbara A., Clay, Thomas A., Cimino, Megan A., Benson, Scott R., Block, Barbara A., Conners, Melinda G., Costa, Daniel P., Jordan, Fredrick D., Leising, Andrew W., Mikles, Chloe S., Palacios, Daniel M., Shaffer, Scott A., Thorne, Lesley H., Watson, Jordan T., Holser, Rachel R., Dewitt, Lynn, Bograd, Steven J., Hazen, Elliott L.

“…Marine heatwaves cause widespread environmental, biological, and socio-economic impacts, placing them at the forefront of 21st-century management challenges…”
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Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2 by Becerra-Artiles, Aniuska, Nanaware, Padma P, Muneeruddin, Khaja, Weaver, Grant C, Shaffer, Scott A, Calvo-Calle, J Mauricio, Stern, Lawrence J

“…Seasonal "common-cold" human coronaviruses are widely spread throughout the world and are mainly associated with mild upper respiratory tract infections. The…”
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