Search Results - "Shaffer, Joel"

Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased Throughput by Berman, Judd, Halm, Kathy, Adkison, Kim, Shaffer, Joel

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In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues by EMERSON, D. L, BESTERMAN, J. M, BROWN, H. R, EVANS, M. G, LEITNER, P. P, LUZZIO, M. J, SHAFFER, J. E, STERNBACH, D. D, UEHLING, D, VUONG, A

“…The development of camptothecin-like compounds as inhibitors of topoisomerase I for the treatment of resistant tumors has generated clinical excitement in this…”
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Inotropic and chronotropic activity of berberine on isolated guinea pig atria by Shaffer, J E

“…The cardiac effects of berberine were studied in isolated right and left atrial preparations from guinea pigs. In spontaneously beating right atria, berberine…”
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Pharmacology of ASL-8052, a novel beta-adrenergic receptor antagonist with an ultrashort duration of action by Gorczynski, R J, Shaffer, J E, Lee, R J

“…ASL-8052, a novel beta-adrenergic receptor antagonist, was studied in isolated guinea pig cardiac and tracheal tissues, in isolated frog sciatic nerves, and in…”
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Mechanism of action of arachidonic acid in the isolated perfused rat heart by Shaffer, J E, Malik, K U

“…The purpose of this study was to elucidate the mechanism of action of arachidonic acid in the isolated rat heart perfused with Krebs solution at a constant…”
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Role of alpha-adrenergic receptors in the intrinsic inotropic selectivity of dobutamine in anesthetized dogs by Shaffer, J E, Gorczynski, R J

“…The inotropic selectivity of dobutamine was examined in pentobarbital-anesthetized, vagotomized dogs pretreated with a ganglion blocker. The purpose was to…”
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Use of "N-in-One" dosing to create an in vivo pharmacokinetics database for use in developing structure-pharmacokinetic relationships by Shaffer, J E, Adkison, K K, Halm, K, Hedeen, K, Berman, J

“…The purpose of this work was (1) to determine if useful in vivo pharmacokinetic data could be obtained after simultaneous administration of 5-22 compounds of a…”
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Taurine mobilizing effects of beta alanine and other inhibitors of taurine transport by Shaffer, J E, Kocsis, J J

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Use of a cell-based, lawn format assay to rapidly screen a 442,368 bead-based peptide library by Jayawickreme, Channa K, Sauls, Howard, Bolio, Natalie, Ruan, Jason, Moyer, Mary, Burkhart, Will, Marron, Brian, Rimele, Thomas, Shaffer, Joel

“…A cell-based, lawn format assay utilizing an in situ photocleavage method has been developed that allows the rapid examination of large bead-based compound…”
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Mechanism of Action of Angiotensin II and Bradykinin on Prostaglandin Synthesis and Vascular Tone in the Isolated Rat Kidney: Effect of Ca++ Antagonists and Calmodulin Inhibitors by Cooper, Christy L, Shaffer, Joel E, Malik, Kafait U

“…We have studied the effect of angiotensin II and bradykinin on prostaglandin output and vascular tone during extracellular calcium depletion and administration…”
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Comparison of the parasympatholytic activity of ACC‐9358 and disopyramide by Brown, Barry S., Gorczynski, Richard J., Reynolds, Robert D., Shaffer, Joel E.

“…1 ACC‐9358 (N‐[(3,5‐di(pyrrolidinylmethyl)‐4‐hydroxy)benzoyl]aniline) is a newly developed analogue of changrolin, an antiarrhythmic agent used in the Peoples…”
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