Search Results - "Shaffer, Donald R."

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy by Grada, Zakaria, Hegde, Meenakshi, Byrd, Tiara, Shaffer, Donald R, Ghazi, Alexia, Brawley, Vita S, Corder, Amanda, Schönfeld, Kurt, Koch, Joachim, Dotti, Gianpietro, Heslop, Helen E, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Ahmed, Nabil

“…Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through…”
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Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment by Salsman, Vita S, Chow, Kevin K H, Shaffer, Donald R, Kadikoy, Huseyin, Li, Xiao-Nan, Gerken, Claudia, Perlaky, Laszlo, Metelitsa, Leonid S, Gao, Xiuhua, Bhattacharjee, Meena, Hirschi, Karen, Heslop, Helen E, Gottschalk, Stephen, Ahmed, Nabil

“…Cancer cells can live and grow if they succeed in creating a favorable niche that often includes elements from the immune system. While T lymphocytes play an…”
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Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma by Kakarla, Sunitha, Chow, Kevin KH, Mata, Melinda, Shaffer, Donald R, Song, Xiao-Tong, Wu, Meng-Fen, Liu, Hao, Wang, Lisa L, Rowley, David R, Pfizenmaier, Klaus, Gottschalk, Stephen

“…Cancer-associated fibroblasts (CAFs), the principle component of the tumor-associated stroma, form a highly protumorigenic and immunosuppressive…”
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T Cells Redirected to EphA2 for the Immunotherapy of Glioblastoma by Chow, Kevin KH, Naik, Swati, Kakarla, Sunitha, Brawley, Vita S, Shaffer, Donald R, Yi, Zhongzhen, Rainusso, Nino, Wu, Meng-Fen, Liu, Hao, Kew, Yvonne, Grossman, Robert G, Powell, Suzanne, Lee, Dean, Ahmed, Nabil, Gottschalk, Stephen

“…Outcomes for patients with glioblastoma (GBM) remain poor despite aggressive multimodal therapy. Immunotherapy with genetically modified T cells expressing…”
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In vivo discovery of immunotherapy targets in the tumour microenvironment by Zhou, Penghui, Shaffer, Donald R., Alvarez Arias, Diana A., Nakazaki, Yukoh, Pos, Wouter, Torres, Alexis J., Cremasco, Viviana, Dougan, Stephanie K., Cowley, Glenn S., Elpek, Kutlu, Brogdon, Jennifer, Lamb, John, Turley, Shannon J., Ploegh, Hidde L., Root, David E., Love, J. Christopher, Dranoff, Glenn, Hacohen, Nir, Cantor, Harvey, Wucherpfennig, Kai W.

“…Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable responses in a subset of cancer patients, despite advanced…”
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Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors by Umiker, Ben, Hashambhoy-Ramsay, Yasmin, Smith, Jeff, Rahman, Tanzila, Mueller, Amy, Davidson, Rachel, Meyer, Christina, Patankar, Gayatri, Alam, Mohammad Murshid, Jaffe, Sarah, Krukenberg, Kristin, Goodman, Allison, Spaulding, Vikki, Priess, Michelle, Dhaneshwar, Abha, Wong, Masie, Diiorio, Alexa, O'Malley, Kristin, McGrath, Lara, Willer, Margaret, Pepper, Lauren, Gostissa, Monica, Kis-Toth, Katalin, Wiederschain, Dmitri, Cohen, Heather, Shaffer, Donald R

“…Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+…”
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PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy by Wang, Lei, Xiao, Yufeng, Luo, Yuewan, Master, Rohan P, Mo, Jiao, Kim, Myung-Chul, Liu, Yi, Maharjan, Chandra K, Patel, Urvi M, De, Umasankar, Carelock, Madison E, Tithi, Tanzia Islam, Li, Xiangming, Shaffer, Donald R, Guertin, Kevin R, Zhuang, Haoyang, Moser, Emily, Smalley, Keiran S M, Lv, Dongwen, Zhou, Daohong, Zheng, Guangrong, Zhang, Weizhou

“…An effective cancer therapy requires killing cancer cells and targeting the tumor microenvironment (TME). Searching for molecules critical for multiple cell…”
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Immunotherapeutic options for Epstein-Barr virus-associated lymphoproliferative disease following transplantation by Shaffer, Donald R, Rooney, Cliona M, Gottschalk, Stephen

“…Epstein-Barr virus-associated lymphoproliferative diseases (EBV-LPD) after hematopoietic stem cell transplantation or solid-organ transplantation remain a…”
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T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies by Shaffer, Donald R., Savoldo, Barbara, Yi, Zhongzhen, Chow, Kevin K.H., Kakarla, Sunitha, Spencer, David M., Dotti, Gianpietro, Wu, Meng-Fen, Liu, Hao, Kenney, Shannon, Gottschalk, Stephen

“…T-cell therapy with genetically modified T cells targeting CD19 or CD20 holds promise for the immunotherapy of hematologic malignancies. These targets,…”
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Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody by Weaver, Jessica D., Stack, Edward C., Buggé, Joshua A., Hu, Changyun, McGrath, Lara, Mueller, Amy, Wong, Masie, Klebanov, Boris, Rahman, Tanzila, Kaufman, Rosemary, Fregeau, Christine, Spaulding, Vikki, Priess, Michelle, Legendre, Kristen, Jaffe, Sarah, Upadhyay, Dhruvkumar, Singh, Anirudh, Xu, Chang-Ai, Krukenberg, Kristin, Zhang, Yan, Ezzyat, Yassine, Saddier Axe, Dorothée, Kuhne, Michelle R., Meehl, Michael A., Shaffer, Donald R., Weist, Brian M., Wiederschain, Dmitri, Depis, Fabien, Gostissa, Monica

“…The presence of T regulatory (Treg) cells in the tumor microenvironment is associated with poor prognosis and resistance to therapies aimed at reactivating…”
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Milliken’s Bend: A Civil War Battle in History and Memory by Linda Barnickel (review) by Shaffer, Donald R

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Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma by GHAZI, Alexia, ASHOORI, Aidin, HEGDE, Meenakshi, LEEN, Ann M, BOLLARD, Catherine M, ROONEY, Cliona M, HESLOP, Helen E, GOTTSCHALK, Stephen, AHMED, Nabil, HANLEY, Patrick J, BRAWLEY, Vita S, SHAFFER, Donald R, KEW, Yvonne, POWELL, Suzanne Z, GROSSMAN, Robert, GRADA, Zakaria, SCHEURER, Michael E

“…Glioblastoma (GBM) is the most common primary brain cancer in adults and is virtually incurable. Recent studies have shown that cytomegalovirus (CMV) is…”
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Expansion of T cells targeting multiple antigens of cytomegalovirus, Epstein–Barr virus and adenovirus to provide broad antiviral specificity after stem cell transplantation by Hanley, Patrick J, Shaffer, Donald R, Cruz, Conrad R.Y, Ku, Stephanie, Tzou, Benjamin, Liu, Hao, Demmler-Harrison, Gail, Heslop, Helen E, Rooney, Clio M, Gottschalk, Stephen, Bollard, Catherine M

“…Abstract Background aims Hematopoietic stem cell transplant (HSCT) is the treatment of choice for a proportion of patients with hematologic malignancies as…”
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Bluejackets and Contrabands: African Americans and the Union Navy by Barbara Brooks Tomblin (review) by Shaffer, Donald R

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Genetic Modification of T Cells With IL-21 Enhances Antigen Presentation and Generation of Central Memory Tumor-specific Cytotoxic T-lymphocytes by KAKA, Anjum S, SHAFFER, Donald R, HARTMEIER, Ryan, LEEN, Ann M, AN LU, BEAR, Adham, ROONEY, Cliona M, FOSTER, Aaron E

“…An optimized antigen-presenting cell for tumor immunotherapy should produce a robust antigen specific cytotoxic T lymphocytes (CTL) response to…”
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Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection by Shaffer, Donald R., Sheehan, Andrea M., Yi, Zhongzhen, Rodgers, Cheryl C., Bollard, Catherine M., Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E., Gottschalk, Stephen

“…Severe chronic active Epstein–Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T‐cell…”
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Foreign or Domestic CARs: Receptor Ligands as Antigen-Binding Domains by Shaffer, Donald, Zhou, Penghui, Gottschalk, Stephen

“…Chimeric antigen receptors (CARs) are increasingly being used in clinical trials to treat a variety of malignant conditions and recent results with…”
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Graduate students bring clinical know-how into their lab work through the HHMI Med into Grad program by Hartmaier, Ryan J, Shaffer, Donald R

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Dissecting the tumor micro-environment in triple negative breast cancer identifies a mutually exclusive expression pattern of the immune co-inhibitory molecules B7-H4 and PD-L1 by Shaffer, Donald R, Cortez-Retamozo, Virna, Nagashima, Kumiko, Zi, Tong, Shu, ChengYi J, Feldman, Igor, Neumeister, Veronique, Smith, Jeff, Zafari, Mohammad, Larson, Rebecca, Silver, Matthew, Mabry, Robert, Briskin, Michael, Novobrantseva, Tanya, Rimm, David, Sathyanarayanan, Sriram

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Abstract 5007: Preclinical evaluation of JTX-8064, an anti-LILRB2 antagonist antibody, for reprogramming tumor-associated macrophages by Cohen, Heather, Hashambhoy-Ramsay, Yasmin, Pepper, Lauren R., Smith, Jeffrey Y., Willer, Margaret, Guay, Kevin, Spaulding, Vikki, O'Malley, Kristin, Gostissa, Monica, Dhaneshwar, Abha, Stack, Edward C., Mora, Alessandro, Shaffer, Donald R.

“…Introduction: Jounce has generated cell type-specific gene signatures as a means of probing The Cancer Genome Atlas and other large datasets to identify…”
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